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Chemical Properties Usage Toxicity Level Toxicity Information Acute Toxicity
Chemical Name:
AA;PY;PYR;cp32;Azine;Pirydyna;Piridina;PYRIDINE;ai3-01240;FEMA 2932
Molecular Formula:
Formula Weight:
MOL File:

Pyridine Properties

Melting point:
-42 °C
Boiling point:
96-98 °C(lit.)
0.983 g/mL at 20 °C
vapor density 
2.72 (vs air)
vapor pressure 
23.8 mm Hg ( 25 °C)
refractive index 
n20/D 1.509(lit.)
Flash point:
68 °F
storage temp. 
Store at RT.
H2O: in accordance
5.25(at 25℃)
Relative polarity
8.81 (H2O, 20℃)
explosive limit
Water Solubility 
Stable. Flammable. Incompatible with strong oxidizing agents, strong acids.
CAS DataBase Reference
110-86-1(CAS DataBase Reference)
NIST Chemistry Reference
EPA Substance Registry System
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T,N,F,Xn
Risk Statements  11-20/21/22-39/23/24/25-23/24/25-52-36/38
Safety Statements  36/37/39-38-45-61-28A-26-28-24/25-22-36/37-16-7
RIDADR  UN 1282 3/PG 2
WGK Germany  2
RTECS  UR8400000
Hazard Note  Highly Flammable/Harmful
HazardClass  3
PackingGroup  II
Hazardous Substances Data 110-86-1(Hazardous Substances Data)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H311 Toxic in contact with skin Acute toxicity,dermal Category 3 Danger P280, P302+P352, P312, P322, P361,P363, P405, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning P280,P302+P352, P312, P322, P363,P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H331 Toxic if inhaled Acute toxicity,inhalation Category 3 Danger P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning P261, P271, P304+P340, P312
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P311 Call a POISON CENTER or doctor/physician.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P370+P378 In case of fire: Use … for extinction.
P403+P235 Store in a well-ventilated place. Keep cool.

Pyridine price More Price(69)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 02486 Pyridine analytical standard 110-86-1 1ml $27.3 2017-11-08 Buy
Sigma-Aldrich 1.07462 Pyridine 110-86-1 1EA $118 2017-11-08 Buy
Alfa Aesar 19378 Pyridine, ACS, 99.0% min 110-86-1 *4x1L $329 2017-11-08 Buy
Alfa Aesar 19378 Pyridine, ACS, 99.0% min 110-86-1 1L $107 2017-11-08 Buy
Sigma-Aldrich 1.09728 Pyridine 110-86-1 2EA $115 2017-11-08 Buy

Pyridine Chemical Properties,Uses,Production

Chemical Properties

Pyridine (Chemical formula C6H5N) is a six-membered heterocyclic compound that contains one nitrogen heteroatom, similar to benzene; it has the same electron structure and aromatic characteristic, so it is also called nitrobenzene and azobenzene. Pyridine is a colorless liquid with a unique smell at room temperature. Its melting point is -41.6℃, and its boiling point is 115.2℃. When it forms an azeotropic mixture with water, its boiling point is 92~93℃. Pyridine’s density is 0.9819 g/cm3. It is easily soluble in water, ethanol, ether, and many other organic solvents. It can also serve as a solvent itself. Pyridine and its derivatives are more stable than benzene, and its reactivity is similar to nitrobenzene. Its reactivity is lower than benzene and does not easily undergo nitration, halogenation, sulfonation and other reactions. Additionally, these substitution reactions must occur in an acidic medium. 2- or 4-halopyridine halogens are both active. As electron density is lower at 2nd and 6th position, there may be nucleophilic substitution reactions, such as reaction with sodium amide or potassium hydroxide, that respectively result in 2-aminopyridine or 2-hydroxypyridine. Pyridine is a weak tertiary amine, and when placed in ethanol solution with many acids (such as picric acid or perchloric acid), it will form salt that is insoluble in water. Industrially used pyridine contains 1% 2-methylepyridine, so that differences in its salt properties can separate it from its homologues. Pyridine can also form crystalline complexes with many metal ions. Pyridine is easier to reduce than benzene; for example, it can be reduced to hexahydropyridine (or piperidine) under the effects of metal sodium and ethanol. When reacted with hydrogen peroxide, pyridine is easily oxidized into N-oxide pyridine. N-oxide pyridine is an important pyridine derivative; since the nitrogen atom is oxidized, it cannot form a positive pyridine ion, making it beneficial to aromatic electrophilic substitution reactions. After the substitution, and the nitrogen on oxygen is removed, this results in a derivative that cannot be gained from a direct substitution of pyridine.


Pyridine is mostly used as a pharmaceutical raw material, solvent and denaturant, and in the production of rubber, paint, resin, corrosion inhibitor, etc. Pyridine can be used as an analytical reagent, and is also used in the organic synthesis industry, chromatography, etc. It can also be used to extract and isolate pyridine and homologous raw materials. According to GB 2760—1996, pyridine is allowed as a food additive. It is used as a raw material for herbicides, insecticides, pharmaceuticals, rubber auxiliaries and textile auxiliaries. Pyridine can be used to produce vitamins, sulfonamides, pesticides, plastic, etc. It is also used industrially as a dyeing agent and a starting material for products such as medicine, disinfectants, dyes, food seasonings, adhesives, explosives, etc. Pyridine pesticides are the global fourth generation of new pesticides and have strong advantages. Pyridine pesticides are highly effective, minimally toxic, long-lasting, and are also environmentally compatible with humans and organisms, thus meeting the demands of pesticide development. Recently, pyridine pesticides are developing quickly and covering the three main categories of insecticide, herbicide and fungicide. Chemical compounds containing pyridine have already become one of the most important aspects of pesticide production. Pyridine compounds are mainly used to produce the herbicides Paraquat and Dike Fast, Nicotinic Acid and Nicotinamide, as well as serving as an intermediate for pesticides. It has a wide variety of uses and broad potential.

Toxicity Level

Low Toxicity

Toxicity Information

Paths of entry: Inhalation, ingestion, absorption through skin. Health risks: Strongly irritative; can anesthetize the central nervous system. Irritates the eyes and upper respiratory tract. When inhaled at a high concentration, it may cause a euphoric or choking sensation, followed by depression, muscle weakness, and nausea; it can also cause a severe loss of consciousness, incontinence, tonic spasms, and a drop in blood pressure. Misuse can cause death. Chronic effects: Long-term inhalation can cause dizziness, headache, insomnia, unsteady walking and disrupted digestion. Liver and kidney damage may occur. Rashes may occur.

Acute Toxicity

LD501580mg/kg (Large mice, oral); 1121mg/kg (Rabbit, through skin); inhaled by human 25mg/m3×20 min, irritation of conjunctiva and upper respiratory tract mucosa. Subacute and chronic toxicity: inhaled by large mice 32.3mg/m3×7 hours/day x5 days/week x6 months, increase in liver weight; inhaled by humans 20~40mg/m3 (long term), nerve damage, unsteady walking, digital tremors, low blood pressure, over-sweating, occasional liver and kidney damage.

Chemical Properties

Colorless to light yellow liquid


Used as solvent; complexing agent.


As solvent for Anhydrous mineral salts. Synthetic intermediate in laboratory and industry.


ChEBI: An azaarene comprising a benzene core in which one -CH group is replaced by a nitrogen atom. It is the parent compound of the class pyridines.

General Description

A clear colorless to light yellow liquid with a penetrating nauseating odor. Density 0.978 g / cm3. Flash point 68°F. Vapors are heavier than air. Toxic by ingestion and inhalation. Combustion produces toxic oxides of nitrogen.

Air & Water Reactions

Highly flammable. Soluble in water.

Reactivity Profile

Azabenzene is a base. Reacts exothermically with acids. During preparation of a complex of Azabenzene with chromium trioxide, an acid, the proportion of chromium trioxide was increased. Heating from this acid-base reaction led to an explosion and fire [MCA Case History 1284 1967]. A 0.1% solution of Azabenzene (or other tertiary amine) in maleic anhydride at 185°C gives an exothermic decomposition with rapid evolution of gas [Chem Eng. News 42(8); 41 1964]. Mixing Azabenzene in equal molar portions with any of the following substances in a closed container caused the temperature and pressure to increase: chlorosulfonic acid, nitric acid (70%), oleum, sulfuric acid (96%), or propiolactone [NFPA 1991]. The combination of iodine, Azabenzene, sulfur trioxide, and formamide developed a gas over pressurization after several months. This arose from the slow formation of sulfuric acid from external water, or from dehydration of the formamide to hydrogen cyanide. Ethylene oxide and SO2 can react violently in Azabenzene solution with pressurization if ethylene oxide is in excess (Nolan, 1983, Case History 51).

Health Hazard

Vapor irritates eyes and nose. Liquid irritates skin and is absorbed through the skin. Overexposure causes nausea, headache, nervous symptoms, increased urinary frequency.

Fire Hazard

Behavior in Fire: Vapor is heavier than air and may travel considerable distance to source of ignition and flash back.

Pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

Pyridine Suppliers

Global( 368)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20810 55
Mainchem Co., Ltd.
0592-6210733 CHINA 3270 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070; CHINA 2952 60
Anhui Royal Chemical Co., Ltd.
+86-025-86736275 CHINA 778 55
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 CHINA 10714 60
Wuhan Sinocon New chemical Materials Co.,ltd. 027-83229541
027-83096702 China 128 62
Nanjing Lanbai Chemical Co., Ltd. +86 (25) 8549-9326,8549-9316,15366059326 13813836665
+86 (25) 8549-9357 China 140 57
Shanghai Macklin Biochemical Co.,Ltd. 15221275939
021-51821727 China 13251 55
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) China 40398 62
021-69106780 China 8323 60

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