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Chemical Properties Usage Toxicity Level Toxicity Information Acute Toxicity

CAS No. 110-86-1
Chemical Name: Pyridine
Synonyms: AA;PY;PYR;cp32;Azine;Pirydyna;Piridina;PYRIDINE;ai3-01240;FEMA 2932
CBNumber: CB8852825
Molecular Formula: C5H5N
Formula Weight: 79.1
MOL File: 110-86-1.mol
Pyridine Property
Melting point : -42 °C
Boiling point : 96-98 °C(lit.)
density : 0.983 g/mL at 20 °C
vapor density : 2.72 (vs air)
vapor pressure : 23.8 mm Hg ( 25 °C)
refractive index : n20/D 1.509(lit.)
FEMA : 2966
Fp : 68 °F
storage temp. : Store at RT.
solubility : H2O: in accordance
form : Liquid
pka: 5.25(at 25℃)
color : colorless
Relative polarity: 0.302
PH: 8.81 (H2O, 20℃)
explosive limit: 12.4%
Water Solubility : Miscible
FreezingPoint : -42℃
Merck : 14,7970
BRN : 103233
Stability:: Stable. Flammable. Incompatible with strong oxidizing agents, strong acids.
CAS DataBase Reference: 110-86-1(CAS DataBase Reference)
NIST Chemistry Reference: Pyridine(110-86-1)
EPA Substance Registry System: Pyridine(110-86-1)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes : T,N,F,Xn
Risk Statements : 11-20/21/22-39/23/24/25-23/24/25-52-36/38
Safety Statements : 36/37/39-38-45-61-28A-26-28-24/25-22-36/37-16-7
RIDADR : UN 1282 3/PG 2
WGK Germany : 2
RTECS : UR8400000
F : 3-10
Hazard Note : Highly Flammable/Harmful
TSCA : Yes
HazardClass : 3
PackingGroup : II
Hazardous Substances Data: 110-86-1(Hazardous Substances Data)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H311 Toxic in contact with skin Acute toxicity,dermal Category 3 Danger P280, P302+P352, P312, P322, P361,P363, P405, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning P280,P302+P352, P312, P322, P363,P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H331 Toxic if inhaled Acute toxicity,inhalation Category 3 Danger P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning P261, P271, P304+P340, P312
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P311 Call a POISON CENTER or doctor/physician.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P370+P378 In case of fire: Use … for extinction.
P403+P235 Store in a well-ventilated place. Keep cool.

Pyridine Chemical Properties,Usage,Production

Chemical Properties
Pyridine (Chemical formula C6H5N) is a six-membered heterocyclic compound that contains one nitrogen heteroatom, similar to benzene; it has the same electron structure and aromatic characteristic, so it is also called nitrobenzene and azobenzene. Pyridine is a colorless liquid with a unique smell at room temperature. Its melting point is -41.6℃, and its boiling point is 115.2℃. When it forms an azeotropic mixture with water, its boiling point is 92~93℃. Pyridine’s density is 0.9819 g/cm3. It is easily soluble in water, ethanol, ether, and many other organic solvents. It can also serve as a solvent itself. Pyridine and its derivatives are more stable than benzene, and its reactivity is similar to nitrobenzene. Its reactivity is lower than benzene and does not easily undergo nitration, halogenation, sulfonation and other reactions. Additionally, these substitution reactions must occur in an acidic medium. 2- or 4-halopyridine halogens are both active. As electron density is lower at 2nd and 6th position, there may be nucleophilic substitution reactions, such as reaction with sodium amide or potassium hydroxide, that respectively result in 2-aminopyridine or 2-hydroxypyridine. Pyridine is a weak tertiary amine, and when placed in ethanol solution with many acids (such as picric acid or perchloric acid), it will form salt that is insoluble in water. Industrially used pyridine contains 1% 2-methylepyridine, so that differences in its salt properties can separate it from its homologues. Pyridine can also form crystalline complexes with many metal ions. Pyridine is easier to reduce than benzene; for example, it can be reduced to hexahydropyridine (or piperidine) under the effects of metal sodium and ethanol. When reacted with hydrogen peroxide, pyridine is easily oxidized into N-oxide pyridine. N-oxide pyridine is an important pyridine derivative; since the nitrogen atom is oxidized, it cannot form a positive pyridine ion, making it beneficial to aromatic electrophilic substitution reactions. After the substitution, and the nitrogen on oxygen is removed, this results in a derivative that cannot be gained from a direct substitution of pyridine.
Pyridine is mostly used as a pharmaceutical raw material, solvent and denaturant, and in the production of rubber, paint, resin, corrosion inhibitor, etc. Pyridine can be used as an analytical reagent, and is also used in the organic synthesis industry, chromatography, etc. It can also be used to extract and isolate pyridine and homologous raw materials. According to GB 2760—1996, pyridine is allowed as a food additive. It is used as a raw material for herbicides, insecticides, pharmaceuticals, rubber auxiliaries and textile auxiliaries. Pyridine can be used to produce vitamins, sulfonamides, pesticides, plastic, etc. It is also used industrially as a dyeing agent and a starting material for products such as medicine, disinfectants, dyes, food seasonings, adhesives, explosives, etc. Pyridine pesticides are the global fourth generation of new pesticides and have strong advantages. Pyridine pesticides are highly effective, minimally toxic, long-lasting, and are also environmentally compatible with humans and organisms, thus meeting the demands of pesticide development. Recently, pyridine pesticides are developing quickly and covering the three main categories of insecticide, herbicide and fungicide. Chemical compounds containing pyridine have already become one of the most important aspects of pesticide production. Pyridine compounds are mainly used to produce the herbicides Paraquat and Dike Fast, Nicotinic Acid and Nicotinamide, as well as serving as an intermediate for pesticides. It has a wide variety of uses and broad potential.
Toxicity Level
Low Toxicity
Toxicity Information
Paths of entry: Inhalation, ingestion, absorption through skin. Health risks: Strongly irritative; can anesthetize the central nervous system. Irritates the eyes and upper respiratory tract. When inhaled at a high concentration, it may cause a euphoric or choking sensation, followed by depression, muscle weakness, and nausea; it can also cause a severe loss of consciousness, incontinence, tonic spasms, and a drop in blood pressure. Misuse can cause death. Chronic effects: Long-term inhalation can cause dizziness, headache, insomnia, unsteady walking and disrupted digestion. Liver and kidney damage may occur. Rashes may occur.
Acute Toxicity
LD501580mg/kg (Large mice, oral); 1121mg/kg (Rabbit, through skin); inhaled by human 25mg/m3×20 min, irritation of conjunctiva and upper respiratory tract mucosa. Subacute and chronic toxicity: inhaled by large mice 32.3mg/m3×7 hours/day x5 days/week x6 months, increase in liver weight; inhaled by humans 20~40mg/m3 (long term), nerve damage, unsteady walking, digital tremors, low blood pressure, over-sweating, occasional liver and kidney damage.
Chemical Properties
Colorless to light yellow liquid
Used as solvent; complexing agent.
ChEBI: An azaarene comprising a benzene core in which one -CH group is replaced by a nitrogen atom. It is the parent compound of the class pyridines.
General Description
A clear colorless to light yellow liquid with a penetrating nauseating odor. Density 0.978 g / cm3. Flash point 68°F. Vapors are heavier than air. Toxic by ingestion and inhalation. Combustion produces toxic oxides of nitrogen.
Air & Water Reactions
Highly flammable. Soluble in water.
Reactivity Profile
Azabenzene is a base. Reacts exothermically with acids. During preparation of a complex of Azabenzene with chromium trioxide, an acid, the proportion of chromium trioxide was increased. Heating from this acid-base reaction led to an explosion and fire [MCA Case History 1284 1967]. A 0.1% solution of Azabenzene (or other tertiary amine) in maleic anhydride at 185°C gives an exothermic decomposition with rapid evolution of gas [Chem Eng. News 42(8); 41 1964]. Mixing Azabenzene in equal molar portions with any of the following substances in a closed container caused the temperature and pressure to increase: chlorosulfonic acid, nitric acid (70%), oleum, sulfuric acid (96%), or propiolactone [NFPA 1991]. The combination of iodine, Azabenzene, sulfur trioxide, and formamide developed a gas over pressurization after several months. This arose from the slow formation of sulfuric acid from external water, or from dehydration of the formamide to hydrogen cyanide. Ethylene oxide and SO2 can react violently in Azabenzene solution with pressurization if ethylene oxide is in excess (Nolan, 1983, Case History 51).
Health Hazard
Vapor irritates eyes and nose. Liquid irritates skin and is absorbed through the skin. Overexposure causes nausea, headache, nervous symptoms, increased urinary frequency.
Fire Hazard
Behavior in Fire: Vapor is heavier than air and may travel considerable distance to source of ignition and flash back.
Pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
4-BROMO-TETRAHYDROPYRAN N-PHENYLISONICOTINAMIDE 2-AMINO-6-CHLORO-3,5-DICYANOPYRIDINE Pyridinium toluene-4-sulphonate Paraquat dichloride 1-CHLORO-2-METHYLPROPYL CHLOROFORMATE 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one Pyrazinecarbonitrile 7-ACETOXYCOUMARIN Phenylcarbamic acid propyl ester 2-Amino-4-methyl-5-acetylthiazole 5-ACETAMIDONICOTINIC ACID Benzyl 2-chloroacetate trans-Ferulic acid 2-AMINO-4-METHYL-QUINOLINE-3-CARBONITRILE 3-(Trifluoromethyl)pyrazole 3-(TRIFLUOROMETHOXY)CINNAMIC ACID 1-Phenacylpyridinium bromide (4-FLUORO-BENZYL)-METHYL-AMINE 5-METHYLPICOLINIC ACID Indigosol Green Blue IBC 2,4-MESITYLENEDISULFONYL DICHLORIDE 17beta-Hydroxy-17-methylandrosta-4,9(11)-dien-3-one 2-(2-Butoxyethoxy)ethyl acetate Allyl methyl carbonate 3,5-DIMETHOXYCINNAMIC ACID 4-Acetamido-2-chloropyridine 4-Fluorocinnamic acid Hydrocortisone acetate Methyl 2-Fluoroisonicotinate 2-ACETYL-5-CYANOTHIOPHENE 5-BROMO-2-FLUOROCINNAMIC ACID 4-NITROISOPHTHALIC ACID Syringaldehyde 2,4,5,6-TETRAMETHYLBENZENEDISULFONYL DICHLORIDE PYRIDINE-3-SULFONYL CHLORIDE 3-Methoxycinnamic acid butyl N-phenylcarbamate 3-(3-METHYL-2-THIENYL)ACRYLIC ACID Vat Grey M
Pyridine Suppliers      Global( 349)Suppliers     
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Wuhan Sinocon New chemical Materials Co.,ltd. 027-83229541
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110-86-1(Pyridine)Related Search:
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ai3-01240 Azine cp32 NCI-C55301 Piridina Pirydyna Pyridin(1.Modifikation) pyridinecarboxylicacid,2-(4,5-dihydro-4-methyl-4-(1-methylethyl)-5-oxo-1h-imidazol-2-yl)-5-methyl pyridinecarboxylicacid,2-(4,5-dihydro-4-methyl-4-(1-methylethyl)-5-oxo-1h-imidazol-2-yl)-5-methyl,monoammoniumsalt Rcra waste number U196 rcrawastenumberu196 FEMA 2932 FEMA 2966 FEMA NUMBER 2966 azabenzene 110-86-1 Alkenes Acyclic Building Blocks 2-PROPENOL 2-Propen-1-c 2-PROPENE-1-OL AA ALLYL ALCOHOL, POLYMER-BOUND AKOS BBS-00004376 Organic Building Blocks PYRIDINE PY PYR PYRIDINE FRACTION Pyridine anhydrous Pyridine 1 Degree Pyridine ACS grade Pyridine pharma grade PYRIDINE, FOR UV-SPECTROSCOPY PYRIDINE, REAGENTPLUS, >=99% PYRIDINE, 99+%, SPECTROPHOTOMETRIC GRADE PYRIDINE, ABSOLUTE, OVER MOLECULAR SIEVE (H2O <0.005%) PYRIDINE, ANHYDROUS, 99.8% PYRIDINE, ACS REAGENT, >=99.0% PYRIDINE 99+% A.C.S. REAGENT (POLY- & PYRIDINE, BIOTECH GRADE SOLVENT, 99.9+% PYRIDINE, DIST., 1 L PYRIDINE PURIFICATION GRADE >=99.75% PYRIDINE CHROMASOLV FOR HPLC >=99.9% PYRIDINE, 99+%, A.C.S. REAGENT PYRIDINE, STANDARD FOR GC PYRIDINE EXTRA PURE PYRIDINE R. G., REAG. ACS, REAG. PH.EUR. PYRIDINE DRIED (MAX. 0,0075 % H2O), R. G ., REAG. PH. EUR. PYRIDINE MIN 99.7% PYRIDINE ACS REAGENT PYRIDINE, FOR PROTEIN SEQUENCE ANALYSIS PYRIDINE, 99+%, A.C.S. REAGENT (SAFETY C AN) PYRIDINE 99+% A.C.S. REAGENT (SAFETY & PYRIDINE, 99.9+%, HPLC GRADE PYRIDINE 99+% PYRIDINE, 4X25 ML
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