ChemicalBook >> CAS DataBase List >>7-Nitroindole-2-carboxylic acid

7-Nitroindole-2-carboxylic acid

CAS No.
6960-45-8
Chemical Name:
7-Nitroindole-2-carboxylic acid
Synonyms
7-NO2-ICA;NSC 69877;CRT0044876;7-Nitro-1H-indoL;CRT0044876, >=97%;TIMTEC-BB SBB003487;NSC 69877,7-NO2-ICA;2-Carboxy-7-nitro-1H-indole;7-NITROINDOLE-2-CARBOXYLIC ACID;7-NITRO-1H-INDOLE-2-CARBOXYLATE
CBNumber:
CB7682546
Molecular Formula:
C9H6N2O4
Molecular Weight:
206.15
MDL Number:
MFCD00044720
MOL File:
6960-45-8.mol
MSDS File:
SDS
Last updated:2023-05-18 11:31:09

7-Nitroindole-2-carboxylic acid Properties

Melting point 260-261 °C
Boiling point 344.99°C (rough estimate)
Density 1.4588 (rough estimate)
refractive index 1.5570 (estimate)
storage temp. Keep in dark place,Sealed in dry,2-8°C
solubility DMSO: >20mg/mL
form Tan solid
pka 4.03±0.30(Predicted)
Water Solubility Insoluble
CAS DataBase Reference 6960-45-8(CAS DataBase Reference)
EPA Substance Registry System 1H-Indole-2-carboxylic acid, 7-nitro- (6960-45-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Danger
Hazard statements  H319-H334
Precautionary statements  P261-P305+P351+P338-P342+P311
Hazard Codes  Xn,Xi
Risk Statements  36/37/38-21/22-43-36
Safety Statements  36/37/39-26-22-36/37
WGK Germany  3
TSCA  Yes
HazardClass  IRRITANT
HS Code  2933998090
NFPA 704
1
2 0

7-Nitroindole-2-carboxylic acid price More Price(36)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C0496 CRT0044876 ≥98% (HPLC) 6960-45-8 10mg $92.2 2024-03-01 Buy
Sigma-Aldrich 262015 DNA Base Excision Repair Pathway Inhibitor 6960-45-8 25mg $130 2024-03-01 Buy
Alfa Aesar B20786 7-Nitroindole-2-carboxylic acid, 96% 6960-45-8 1g $96.65 2024-03-01 Buy
Alfa Aesar B20786 7-Nitroindole-2-carboxylic acid, 96% 6960-45-8 5g $360.65 2024-03-01 Buy
Cayman Chemical 16348 DNA Base Excision Repair Pathway Inhibitor ≥98% 6960-45-8 10mg $44 2024-03-01 Buy
Product number Packaging Price Buy
C0496 10mg $92.2 Buy
262015 25mg $130 Buy
B20786 1g $96.65 Buy
B20786 5g $360.65 Buy
16348 10mg $44 Buy

7-Nitroindole-2-carboxylic acid Chemical Properties,Uses,Production

Chemical Properties

brown powder

Uses

7-Nitro-1H-indole-2-carboxylic Acid is a potent and selective APE1 inhibitor, which at low micromolar concentrations inhibits the AP endonuclease, 3''-phosphodiesterase and 3''-phosphatase activities of APE1 .

Biological Activity

crt0044876 is a potent and selective inhibitor of ape1 with ic50 value of 3.06 μm [1].apurinic/apyrimidinic endonuclease-1 (ape1) is a member of the highly conserved exonucleaseiii family of ap endonucleases and plays an important role in dna repair. ape1 exhibits 3’-phosphodiesterase activity and weak 3’-phosphatase activity, 3’-5’-exonuclease activity and rnaseh activity [1].crt0044876 is a potent and selective ape1 inhibitor. in hela whole cell extract, crt0044876 inhibited apurinic/apyrimidinic (ap) site cleavage catalyzed by ape1. crt0044876 inhibited both the ap endonuclease and exonuclease activities of exonuclease iii, the bacterial homologue of ape1. crt0044876 inhibited the 3’-phosphoglycolate diesterase activity of ape1 with ic50 value of 5 μm and also inhibited 3’-phosphatase activity through binding to dna repair active site of ape1. in ht1080 fibrosarcoma cells, crt0044876 significantly increased ap site accumulation and was non-toxic at concentrations up to 400 μm. also, crt0044876 potentiated the cytotoxicity induced by alkylating agent mms, temozolomide, hydrogen peroxide and hmdurd through specific inhibition of the base excision repair (ber) pathway [1].

References

[1]. madhusudan s, smart f, shrimpton p, et al. isolation of a small molecule inhibitor of dna base excision repair. nucleic acids res, 2005, 33(15): 4711-4724.

7-Nitroindole-2-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 152)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
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Alchem Pharmtech,Inc.
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CONIER CHEM AND PHARMA LIMITED
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Shanghai UCHEM Inc.
+862156762820 +86-13564624040 sales@myuchem.com China 6506 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250 1026@dideu.com China 29831 58

View Lastest Price from 7-Nitroindole-2-carboxylic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
		7-Nitroindole-2-carboxylic acid pictures 2019-12-26 7-Nitroindole-2-carboxylic acid
6960-45-8
US $1.00 / KG 1KG 85.0-99.8% 20 tons Career Henan Chemical Co

7-Nitroindole-2-carboxylic acid Spectrum

TIMTEC-BB SBB003487 7-nitro-1h-indole-2-carboxylicaci 7-NITRO-1H-INDOLE-2-CARBOXYLIC ACID 7-NITROINDOLE-2-CARBOXYLIC ACID 7-Nitroindole-2-carboxylic acid, 90-95% 7-NO2-ICA 2-Carboxy-7-nitro-1H-indole 7-Nitro-1H-indole-2-carboxylic acid 95+% 7-Nitro-2H-indole-2-carboxylic acid 1H-Indole-2-carboxylic acid, 7-nitro- DNA Base Excision Repair Pathway Inhibitor Indole-2-carboxylic acid, 7-nitro- Indole-2-carboxylic acid, 7-nitro- (8CI) CRT0044876, >=97% CRT0044876 NSC 69877,7-NO2-ICA 7-Nitroindole-2-carboxylic acid 7-Nitro-1H-indole-2-carboxylic acid NSC 69877 7-NITRO-1H-INDOLE-2-CARBOXYLATE 7-Nitro-1H-indole-2-carboxylic acid 96+% DNA Base Excision Repair Pathway Inhibitor - CAS 6960-45-8 - Calbiochem 7-Nitro-1H-indoL 7-Nitroindole-2-carboxylic acid USP/EP/BP 6960-45-8 Indoles and derivatives Inhibitors