7-Nitroindole-2-carboxylic acid
- CAS No.
- 6960-45-8
- Chemical Name:
- 7-Nitroindole-2-carboxylic acid
- Synonyms
- 7-NO2-ICA;NSC 69877;CRT0044876;7-Nitro-1H-indoL;CRT0044876, >=97%;TIMTEC-BB SBB003487;NSC 69877,7-NO2-ICA;2-Carboxy-7-nitro-1H-indole;7-NITROINDOLE-2-CARBOXYLIC ACID;7-NITRO-1H-INDOLE-2-CARBOXYLATE
- CBNumber:
- CB7682546
- Molecular Formula:
- C9H6N2O4
- Molecular Weight:
- 206.15
- MDL Number:
- MFCD00044720
- MOL File:
- 6960-45-8.mol
- MSDS File:
- SDS
Melting point | 260-261 °C |
---|---|
Boiling point | 344.99°C (rough estimate) |
Density | 1.4588 (rough estimate) |
refractive index | 1.5570 (estimate) |
storage temp. | Keep in dark place,Sealed in dry,2-8°C |
solubility | DMSO: >20mg/mL |
form | Tan solid |
pka | 4.03±0.30(Predicted) |
color | Light yellow to yellow |
Water Solubility | Insoluble |
CAS DataBase Reference | 6960-45-8(CAS DataBase Reference) |
EPA Substance Registry System | 1H-Indole-2-carboxylic acid, 7-nitro- (6960-45-8) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS08 |
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Signal word | Danger | |||||||||
Hazard statements | H319-H334 | |||||||||
Precautionary statements | P261-P305+P351+P338-P342+P311 | |||||||||
Hazard Codes | Xn,Xi | |||||||||
Risk Statements | 36/37/38-21/22-43-36 | |||||||||
Safety Statements | 36/37/39-26-22-36/37 | |||||||||
WGK Germany | 3 | |||||||||
TSCA | Yes | |||||||||
HazardClass | IRRITANT | |||||||||
HS Code | 2933998090 | |||||||||
NFPA 704 |
|
7-Nitroindole-2-carboxylic acid price More Price(36)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | C0496 | CRT0044876 ≥98% (HPLC) | 6960-45-8 | 10mg | $92.2 | 2024-03-01 | Buy |
Sigma-Aldrich | 262015 | DNA Base Excision Repair Pathway Inhibitor | 6960-45-8 | 25mg | $130 | 2024-03-01 | Buy |
Alfa Aesar | B20786 | 7-Nitroindole-2-carboxylic acid, 96% | 6960-45-8 | 1g | $96.65 | 2024-03-01 | Buy |
Alfa Aesar | B20786 | 7-Nitroindole-2-carboxylic acid, 96% | 6960-45-8 | 5g | $360.65 | 2024-03-01 | Buy |
Cayman Chemical | 16348 | DNA Base Excision Repair Pathway Inhibitor ≥98% | 6960-45-8 | 10mg | $44 | 2024-03-01 | Buy |
7-Nitroindole-2-carboxylic acid Chemical Properties,Uses,Production
Chemical Properties
brown powder
Uses
7-Nitro-1H-indole-2-carboxylic Acid is a potent and selective APE1 inhibitor, which at low micromolar concentrations inhibits the AP endonuclease, 3''-phosphodiesterase and 3''-phosphatase activities of APE1 .
Biological Activity
crt0044876 is a potent and selective inhibitor of ape1 with ic50 value of 3.06 μm [1].apurinic/apyrimidinic endonuclease-1 (ape1) is a member of the highly conserved exonucleaseiii family of ap endonucleases and plays an important role in dna repair. ape1 exhibits 3’-phosphodiesterase activity and weak 3’-phosphatase activity, 3’-5’-exonuclease activity and rnaseh activity [1].crt0044876 is a potent and selective ape1 inhibitor. in hela whole cell extract, crt0044876 inhibited apurinic/apyrimidinic (ap) site cleavage catalyzed by ape1. crt0044876 inhibited both the ap endonuclease and exonuclease activities of exonuclease iii, the bacterial homologue of ape1. crt0044876 inhibited the 3’-phosphoglycolate diesterase activity of ape1 with ic50 value of 5 μm and also inhibited 3’-phosphatase activity through binding to dna repair active site of ape1. in ht1080 fibrosarcoma cells, crt0044876 significantly increased ap site accumulation and was non-toxic at concentrations up to 400 μm. also, crt0044876 potentiated the cytotoxicity induced by alkylating agent mms, temozolomide, hydrogen peroxide and hmdurd through specific inhibition of the base excision repair (ber) pathway [1].
References
[1]. madhusudan s, smart f, shrimpton p, et al. isolation of a small molecule inhibitor of dna base excision repair. nucleic acids res, 2005, 33(15): 4711-4724.
7-Nitroindole-2-carboxylic acid Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2136 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29821 | 58 |
SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34571 | 58 |
Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 7192 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 23799 | 58 |
View Lastest Price from 7-Nitroindole-2-carboxylic acid manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2019-12-26 | 7-Nitroindole-2-carboxylic acid
6960-45-8
|
US $1.00 / KG | 1KG | 85.0-99.8% | 20 tons | Career Henan Chemical Co |
- 7-Nitroindole-2-carboxylic acid
6960-45-8
- US $1.00 / KG
- 85.0-99.8%
- Career Henan Chemical Co
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