L-Homophe-OH | 943-73-7

L-Homophe-OH Properties

Melting point	>300 °C(lit.)
alpha	45 º (C=1, 3N HCl 19 ºC)
Boiling point	311.75°C (rough estimate)
Density	1.1248 (rough estimate)
refractive index	44 ° (C=1, 3mol/L HCl)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Soluble in dilute aqueous acid.
form	Solid
pka	2.32±0.10(Predicted)
color	White to Off-White
InChI	InChI=1/C10H13NO2/c11-9(10(12)13)7-6-8-4-2-1-3-5-8/h1-5,9H,6-7,11H2,(H,12,13)/t9-/s3
InChIKey	JTTHKOPSMAVJFE-VIFPVBQESA-N
SMILES	C(O)(=O)[C@H](CCC1=CC=CC=C1)N \|&1:3,r\|
CAS DataBase Reference	943-73-7(CAS DataBase Reference)
FDA UNII	8JYL44CC06

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H312-H315-H319-H332-H335

Precautionary statements

P261-P280-P305+P351+P338

Hazard Codes

Xi

Safety Statements

22-24/25

WGK Germany

3

HS Code

29224999

NFPA 704

	0
1		0

L-Homophe-OH price More Price(41)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	H0985	L-Homophenylalanine >98.0%(T)	943-73-7	1g	$52	2024-03-01	Buy
TCI Chemical	H0985	L-Homophenylalanine >98.0%(T)	943-73-7	100mg	$16	2024-03-01	Buy
Alfa Aesar	H27295	L-Homophenylalanine, 98%	943-73-7	1g	$61.65	2024-03-01	Buy
Alfa Aesar	H27295	L-Homophenylalanine, 98%	943-73-7	5g	$179.65	2024-03-01	Buy
Alfa Aesar	H27295	L-Homophenylalanine, 98%	943-73-7	25g	$559.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
H0985	1g	$52	Buy
H0985	100mg	$16	Buy
H27295	1g	$61.65	Buy
H27295	5g	$179.65	Buy
H27295	25g	$559.65	Buy

L-Homophe-OH Chemical Properties,Uses,Production

Description

L-Homophenylalanine is an amino acid derivative. It has been extensively used in the pharmaceutical industry as a precursor for production of angiotensin-converting enzyme (ACE) inhibitor: enalapril, delapril, quinapril and ramipril, which possesses significant clinical application in the management of hypertension and congestive heart failure (CHF). It acts as an anti-tumor reagent.

References

Hwang, J. Y., et al. "Simultaneous synthesis of 2-phenylethanol and L-homophenylalanine using aromatic transaminase with yeast Ehrlich pathway." Biotechnology & Bioengineering 102.5(2009):1323-9.
Ahmad, A. L., P. C. Oh, and S. R. Abd Shukor. "Sustainable biocatalytic synthesis of L-homophenylalanine as pharmaceutical drug precursor."Biotechnology Advances 27.3(2009):286-296.
https://www.alfa.com/en/catalog/H27295/

Application

L-homophenylalanine is used almost exclusively as single stereoisomer in pharmaceutical drug production. L-homophenylalanine as a common building block, due to the presence of L-homophenylalanine moiety as the central pharmacophore unit. L-homophenylalanine is also an important chiral intermediate to synthesize a variety of novel pharmaceuticals including β-lactam antibiotics, acetylcholinesterase inhibitor and neutral endopeptidace (NEP) inhibitor which retained their status as major contributors to human health preservation. L-homophenylalanine acts as a precursor for the synthesis of NEP inhibitors, which complements the effects of ACE inhibitors when used simultaneously, potentiates the outcome in the management of hypertension and congestive heart failure[1].

Chemical Properties

White Solid

Uses

Antitumor agent.

Uses

L-Homophenylalanine is used as a precursor in the pharmaceutical industry for the production of angiotensin-converting enzyme (ACE) and R-(-)-Homophenylalanin-ethylester. It is also involved in the synthesis of NEPA [(S,S)-N-(1-Ethoxycarbonyl-3-phenylpropyl)alanine], which is a key intermediate to prepare the ACE-inhibitors: enalapril, delapril, quinapril and ramipril. It acts as an anti-tumor reagent.

Definition

ChEBI: A non-proteinogenic L-alpha-amino acid that is an analogue of L-phenylalanine having a 2-phenylethyl rather than a benzyl side-chain.

Production Methods

Asymmetric reduction of prochiral ketone remains one of the most investigated methods to date for production of chiral L-homophenylalanine. One of the most established method for synthesizing L-homophenylalanine on a laboratory scale was carried out via enzyme-catalyzed asymmetric synthesis of keto acids. In this method, prochiral ketone was converted via reductive amination to enantiopure products with bulky side chains by addition of biocatalysts such as L-homophenylalanine dehydrogena. in the presence of cofactor. L-phenylalanine dehydrogenase is by and large preferred as it has mainly a catabolic function and accepts a wide variety of keto acids as substrates hence it is generally employed in the synthesis of L-homophenylalanine which carries very bulky side chains[1].

References

[1] Ahmad A, et al. Sustainable biocatalytic synthesis of L-homophenylalanine as pharmaceutical drug precursor. Biotechnology Advances, 2009; 27: 286-296.

L-Homophe-OH synthesis

Synthesis of L-Homophe-OH from Benzenebutanoic acid, α-amino-, sodium salt (1:1), (αS)-

L-Homophe-OH Preparation Products And Raw materials

Raw materials

4-Morpholinecarboxylic acid, 2-oxo-3-(2-oxo-2-phenylethyl)-5,6-diphenyl-, phenylmethyl ester, (3S,5S,6R)- 2-acetamido-4-phenyl-butanoic acid D-Homophenylalanine (1R,2S)-2-Amino-1,2-diphenylethanol Benzyl (2R,3S)-(-)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate

E-PHENYLETHENYLBORONIC ACID N-[(1S,2R)-2-Hydroxy-1,2-diphenylethyl]-glycine Ethyl Ester 2-Oxo-4-phenylbutyric acid

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Preparation Products

L-Homophenylalanine ethyl ester hydrochloride N-[(S)-(+)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanine (S)-4-Nitro-hoMophenylalanine (S)-2-amino-4-phenylbutan-1-ol

L-Homophe-OH Suppliers

Global( 541)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
DONBOO AMINO ACID COMPANY	+8613063595538	donboo@donboo.com	China	9365	58
Sichuan HongRi Pharma-Tech Co.,Ltd	+86-028-64841719 +8618980456393	daisy@enlaibio.com	China	1369	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Chongqing Zhihe Biopharmaceutical Co., Ltd.	+86-18580541567 +86-17782035140	sales@zhswyy.com	China	338	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Taizhou Tianhong Biochemistry Technology Co., Ltd.	0523-86132544	sales@thbiochem.com	CHINA	305	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60

Supplier	Advantage
DONBOO AMINO ACID COMPANY	58
Sichuan HongRi Pharma-Tech Co.,Ltd	58
Hebei Mojin Biotechnology Co., Ltd	58
Chongqing Zhihe Biopharmaceutical Co., Ltd.	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Taizhou Tianhong Biochemistry Technology Co., Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60

View Lastest Price from L-Homophe-OH manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-26	L-Homophe-OH 943-73-7	US $0.00-0.00 / kg	0.10000000149011612kg	99	20tons	Chongqing Zhihe Biopharmaceutical Co., Ltd.
2024-04-26	L-Homophe-OH 943-73-7	US $0.00-0.00 / kg	1kg	99%	1T+	Sichuan HongRi Pharma-Tech Co.,Ltd
2023-10-16	L-Homophenylalanine 943-73-7	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mojin Biotechnology Co., Ltd

L-Homophe-OH
943-73-7
US $0.00-0.00 / kg
99
Chongqing Zhihe Biopharmaceutical Co., Ltd.

L-Homophe-OH
943-73-7
US $0.00-0.00 / kg
99%
Sichuan HongRi Pharma-Tech Co.,Ltd

L-Homophenylalanine
943-73-7
US $0.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

943-73-7(L-Homophe-OH)Related Search:

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L-Homophenylalanine ethyl ester hydrochloride Phenylacetone N-[(tert-Butoxy)carbonyl]-D-tryptophan FMOC-4-TRIFLUOROMETHYL-D-BETA-HOMOPHENYLALANINE BOC-(S)-3-AMINO-4-(4-CHLORO-PHENYL)-BUTYRIC ACID

[-/+]-2-AMINO-4-PHENYLBUTYRIC ACID,DL-ALPHA-AMINO-4-PHENYLBUTYRIC ACID 2,4-DICHLORO-L-BETA-HOMOPHENYLALANINE HYDROCHLORIDE N-T-BUTOXYCARBONYL-(S)-3-AMINO-4-PHENYLBUTYRIC ACID,(S)-3-(BOC-AMINO)-4-PHENYLBUTYRIC ACID

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(+)-2-Amino-4-phenylbutyric acid,98% S)-α-Amino-benzenebutanoic acid L-(S)-Homophenylalanine.HCl L-Homophenylalanine ,98% H-L-HPA-OH Benzenebutanoicacid, a-aMino-, (aS)- H-HoMophe-OH(HoMophenylalanine) RARECHEM BK PT 0049 (S)-(+)-2-AMINO-4-PHENYLBUTYRIC ACID (S)-2-AMINO-4-PHENYLBUTYRIC ACID (S)-HOMOPHENYLALANINE (2S)-2-Amino-4-phenylbutyric acid (S)-APBA (aS)-α-Aminobenzenebutanoic Acid L-Benzylalanine L--Phenylbutyrine (aS)-a-Aminobenzenebutanoic Acid L-HOMOPHENYLALANINE extrapure L-HPhe-OH Benzenebutanoic acid, alpha-amino-, (S)- Benzenebutanoic acid, .alpha.-amino-, (.alpha.S)- L-Homophe-OH (αS)-α-Amino-benzenebutanoic Acid,99%e.e. 2-(S)-AMINO-4-PHENYLBUTANOIC ACID L-ALPHA-AMINO-4-PHENYLBUTYRIC ACID L-2-AMINO-4-PHENYLBUTYRIC ACID L-HOMOPHE L-(+)-HOMOPHENYLALANINE L-HOMOPHENYLALANINE LHPA H-HPH-OH H-HOMOPHE-OH H-HOPHE-OH H-HFE-OH HOMO-L-PHENYLALANINE HOMOPHENYLALANINE, L- L- Homophenylalanine (LHPA) Homophenyl-L-alanine (+)-2-Amino-4-phenylbutyric acid H-L-HPhe-OH L-Homophenylalanine, (S)-2-Amino-4-phenyl-butyric acid L-Homophenylalanine99% L-Homophenylalanine 99% (2R)-2-amino-4-phenylbutanoic acid (S)-ALPHA-AMINOBENZENEBUTANOIC ACID TIANFUCHEM--943-73-7---L-Homophenylalanine L-Homophenylalanine USP/EP/BP -HomophenyL L-Homophenylalanine> (2S)-2-ammonio-4-cyclohexylbutanoate Boc-D-&beta Fmoc-4-nitro-L-&beta Benzenebutanoic acid, α-amino-, (αS)- HOMOPHENYLALANINE HPHE (S)-2-AMINO-4-PHENYLBUTANOIC ACID L-Homophenylalanine,97% (αS)?-α-?Amino-benzenebutanoic Acid