ADIPORON
- CAS No.
- 924416-43-3
- Chemical Name:
- ADIPORON
- Synonyms
- CS-918;104890;AdipiRon;AdipoRon;SC-396658;AdipoR agonist;AdipoRon (SC-396658);924416-43-3, CFCD924416433,;2-(4-benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetaMide;2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide
- CBNumber:
- CB82681793
- Molecular Formula:
- C27H28N2O3
- Molecular Weight:
- 428.52
- MDL Number:
- MFCD08271060
- MOL File:
- 924416-43-3.mol
- MSDS File:
- SDS
| Melting point | 106-108°C |
|---|---|
| Boiling point | 645.3±55.0 °C(Predicted) |
| Density | 1.21±0.1 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | DMSO: soluble10mg/mL, clear |
| pka | 13.92±0.20(Predicted) |
| form | powder |
| color | white to beige |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months. |
| FDA UNII | ND7UVH6GKJ |
ADIPORON price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0998 | AdipoRon ≥98% (HPLC) | 924416-43-3 | 5mg | $118 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0998 | AdipoRon ≥98% (HPLC) | 924416-43-3 | 25mg | $476 | 2024-03-01 | Buy |
| Cayman Chemical | 15941 | AdipoRon ≥98% | 924416-43-3 | 5mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 15941 | AdipoRon ≥98% | 924416-43-3 | 10mg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 15941 | AdipoRon ≥98% | 924416-43-3 | 25mg | $161 | 2024-03-01 | Buy |
ADIPORON Chemical Properties,Uses,Production
Description
Adiponectin expressed by adipocytes exerts antidiabetic effects by binding to adiponectin receptor (AdipoR)1, which activates AMPK pathways, and AdipoR2, which activates PPARα pathways. AdipoRon is an orally active small molecule AdipoR agonist that binds AdipoR1 and AdipoR2 with KD values of 1.8 and 3.1 μM, respectively. At 50 mg/kg, it acts similarly to adiponectin, activating AMPK and PPARα pathways and reducing insulin resistance and glucose intolerance in wild type mice fed a high-
Uses
AdipoRon is an AdipoR agonist and activates AMPK and PPAR-α pathways in the muscle and liver. AdipoRon ameliorated diabetes of genetically obese rodent model db/db mice, and prolonged the shortened lifespan of db/db mice on a high-fat diet. AdipoRon is a promising therapeutic approach for the treatment of obesity-related diseases such as type 2 diabetes.
Biochem/physiol Actions
AdipoRon is an adiponectin agonist that binds to and activates adiponectin receptors AdipoR1 and AdipoR2, activating AMPK and PPAR-α pathways, and ameliorating insulin resistance and glucose intolerance in mice fed a high-fat diet in a manner similar to adiponectin itself. AdipoRon did not affect body weight, but did increase the expression of genes involved in fatty-acid oxidation, decreased tissue triglyceride content, and prolonged the shortened lifespan of db/db mice.
storage
+4°C
References
1) Okada-Iwabu?et al. (2013),?A small-molecule AdipoR agonist for type 2 diabetes and short life obesity; Nature 503?493 2) Fairaq?et al.?(2017),?AdipoRon, an adiponectin receptor agonist, attenuates PDGF-induced VSMC proliferation through inhibition of mTOR signaling independent of AMPK: Implications toward suppression of neointimal hyperplasia; Pharmacol. Res.?119?289
ADIPORON Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | 18522618860@163.com | China | 694 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Chemia Biotechnology（Shanghai） Co., Ltd | +8613816753574 | info@chemia-pharm.com | CHINA | 311 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| Henan Alfa Chemical Co., Ltd | +8618339805032 | alfa4@alfachem.cn | China | 12755 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
View Lastest Price from ADIPORON manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-09-02 | SC-396658;AdipoRon;2-(4-benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetaMide
924416-43-3
|
US $1.00-2.00 / KG | 1KG | 98% | 1kg; 2kg；10kg; 100kg | Career Henan Chemical Co |
-
- SC-396658;AdipoRon;2-(4-benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetaMide
924416-43-3
- US $1.00-2.00 / KG
- 98%
- Career Henan Chemical Co