FRIEDELIN
- CAS No.
- 559-74-0
- Chemical Name:
- FRIEDELIN
- Synonyms
- FRIEDELAN-3-ONE;FRIEDELIN;Nsc 55141;Friedeline;FRIEDELIN hplc;3-Friedelanone;Einecs 209-205-1;FRIEDELIN, TECH.;FRIEDELIN WITH HPLC;DA-FRIEDOOLEANAN-3-ONE
- CBNumber:
- CB8702821
- Molecular Formula:
- C30H50O
- Molecular Weight:
- 426.72
- MDL Number:
- MFCD00017296
- MOL File:
- 559-74-0.mol
- MSDS File:
- SDS
| Melting point | 262-265 °C (lit.) |
|---|---|
| alpha | D -27.8° (chloroform) |
| Boiling point | 477.2±13.0 °C(Predicted) |
| Density | 0.963±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White to Off-White |
| optical activity | -2214 (c 0.8, CHCl3) |
| Merck | 13,4293 |
| BRN | 1916451 |
| LogP | 10.287 (est) |
| FDA UNII | AK21264UAD |
| UNSPSC Code | 85151701 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
| WGK Germany | 3 |
FRIEDELIN price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 855022 | Friedelin technical grade | 559-74-0 | 1g | $428 | 2025-07-31 | Buy |
| Sigma-Aldrich | 92187 | Friedelin analytical standard | 559-74-0 | 10mg | $214 | 2022-05-15 | Buy |
| TRC | F765000 | Friedelin | 559-74-0 | 10mg | $250 | 2021-12-16 | Buy |
| Usbiological | 361792 | Friedelin | 559-74-0 | 10mg | $632 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb593936 | Friedelin | 559-74-0 | 10mg | $666.4 | 2021-12-16 | Buy |
FRIEDELIN Chemical Properties,Uses,Production
Uses
Friedelin is a flavonoid extract which displays radical scavenging and anti-typhoid activity.
Uses
Friedelin can be used as a starting material in the synthesis of:
- Friedel-3-enol acetate, friedel-2-oxo-3-enol acetate, friedel-2-ene derivatives and friedelin ketoxime.
- Oxygenated friedelin derivatives as potent DNA topoisomerase IIα inhibitors.
- Its 1,4-pyrazine derivatives as potent antimicrobial agents.
Definition
ChEBI: Friedelin is a pentacyclic triterpenoid that is perhydropicene which is substituted by an oxo group at position 3 and by methyl groups at the 4, 4a, 6b, 8a, 11, 11, 12b, and 14a-positions (the 4R,4aS,6aS,6bR,8aR,12aR,12bS,14aS,14bS-enantiomer). It is the major triterpenoid constituent of cork. It has a role as an anti-inflammatory drug, a non-narcotic analgesic, an antipyretic and a plant metabolite. It is a pentacyclic triterpenoid and a cyclic terpene ketone.
General Description
Friedelin, a pentacyclic triterpene, is found in several plants like Cissus quadrangularis, Celastrus vulcanicola, Terminalia?avicennioides, and Alangium salvifolium. It is known to act as a histamine H1 receptor?(H1R) antagonist, anti-microbial, anti-HIV, and anti-cancer agent.
in vivo
Friedelin (40 mg/kg, p.o., single dose) exhibits potent anti-inflammatory activity in the carrageenan (HY-125474)-induced acute inflammation Wistar rat model[2]. Friedelin (30 mg/kg, i.p., once daily, for 14 days) alleviats neuronal dysfunction and memory impairment in the scopolamine (HY-N0296)-induced neurodegeneration mouse model[3]. Friedelin (40 μM, local injection near the right Achilles tendon, once weekly, for 4 weeks) prevents the progression of tendinopathy in the type I collagenase (HY-E70005A)-induced tendinopathy C57BL/6 mouse model[4].
| Animal Model: | Scopolamine (HY-N0296)-induced neurodegeneration mice model[3] |
| Dosage: | 30 mg/kg |
| Administration: | Intraperitoneal injection (i.p.), once daily, for 14 days |
| Result: | Improved scopolamine-induced oxidative stress, neurodegeneration, and memory impairment. |
| Animal Model: | Carrageenan (HY-125474)-induced acute inflammation Wistar rats model[2] |
| Dosage: | 40 mg/kg |
| Administration: | Oral gavage (p.o.), single dose |
| Result: | Maximally inhibited acute inflammatory response, significantly reduced paw edema thickness. |
| Animal Model: | Collagenase Type I (HY-E70005A)-induced tendinopathy C57BL/6 mice model[4] |
| Dosage: | 40 μM |
| Administration: | Local injection near the right Achilles tendon, once weekly, for 4 weeks |
| Result: | Significantly improved tendon mechanical strength, reduced inflammatory cell infiltration, restored ordered collagen fiber arrangement. |
IC 50
CYP2; CYP3
FRIEDELIN Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| Chengdu Greenpure Biopharma CO.,Ltd | 18283602253; +8618283602253 | jancyzheng@gcgreenpure.com | China | 954 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3751 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 | 1015@dideu.com | China | 3969 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32376 | 58 |
| Aktin Chemicals, Inc. | 028-85159085 | info@aktinchem.com | CHINA | 1025 | 58 |
View Lastest Price from FRIEDELIN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-07-16 | Friedelin
559-74-0
|
US $81.00-318.00 / mg | 98.87% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-06-20 | friedelin
559-74-0
|
US $0.00 / kg | 1kg | 0.99 | 20tons | Hebei Yanxi Chemical Co., Ltd. | |
 |
2023-02-24 | Friedelin
559-74-0
|
US $0.00 / mg | 5mg | ≥95%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. |
