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12-Crown-4

12-Crown-4 structure

CAS No.: 294-93-9

Chemical Name:: 12-Crown-4

Synonyms: Crown;1,4,7,10-TETRAOXACYCLODODECANE;12-CROWN 4-ETHER;Eoct;12C4;12 C 4;12-C-4;12-CROWN-4;12-Crown-4,97%;LITHIUM IONOPHORE V

CBNumber:: CB8752442

Molecular Formula:: C8H16O4

Molecular Weight:: 176.21

MDL Number:: MFCD00005103

MOL File:: 294-93-9.mol

MSDS File:: SDS

Last updated:2023-04-23 13:52:06

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12-Crown-4 Properties

Melting point	16 °C (lit.)
Boiling point	61-70 °C/0.5 mmHg (lit.)
Density	1.089 g/mL at 25 °C (lit.)
refractive index	n20/D 1.463(lit.)
Flash point	>230 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	Liquid After Melting
Specific Gravity	1.115 (20℃)
color	Clear colorless to slightly yellow
Water Solubility	MISCIBLE
Sensitive	Air Sensitive
BRN	1363064
CAS DataBase Reference	294-93-9(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	K6069P2C2A
NIST Chemistry Reference	12-Crown-4(294-93-9)
EPA Substance Registry System	1,4,7,10-Tetraoxacyclododecane (294-93-9)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H330

Precautionary statements

Hazard Codes

Risk Statements

Safety Statements

RIDADR

UN 2810

WGK Germany

RTECS

XF0550000

3-9-23

TSCA

Yes

HazardClass

6.1

PackingGroup

III

HS Code

29329995

Toxicity

LD50 oral in rat: 2830mg/kg

NFPA 704

	1
4		1

12-Crown-4 price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	194905	12-Crown-4 98%	294-93-9	1g	$62.5	2024-03-01	Buy
Sigma-Aldrich	194905	12-Crown-4 98%	294-93-9	5g	$148	2024-03-01	Buy
TCI Chemical	C0858	12-Crown 4-Ether >95.0%(GC)	294-93-9	1mL	$54	2024-03-01	Buy
TCI Chemical	C0858	12-Crown 4-Ether >95.0%(GC)	294-93-9	5mL	$177	2024-03-01	Buy
Alfa Aesar	A11972	12-Crown-4, 98%	294-93-9	1g	$76.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
194905	1g	$62.5	Buy
194905	5g	$148	Buy
C0858	1mL	$54	Buy
C0858	5mL	$177	Buy
A11972	1g	$76.65	Buy

12-Crown-4 Chemical Properties,Uses,Production

Chemical Properties

clear colorless to slightly yellow liquid after

Uses

It serves as an aprotic "solvent" for alkali metals, the sodium solution is a strong reducing agent.

Uses

12-Crown-4 can be used as:

A promoter in the synthesis of poly(diethylsiloxane) (PDES) from monomer hexaethylcyclotrisiloxane using NaOH as a catalyst via anionic ring-opening polymerization.
As an additive in the preparation of triarylmethane derivatives by palladium-catalyzed cross coupling reaction of aryl bromides with diarylmethane derivatives.
A phase transfer catalyst in organic synthesis.

Definition

ChEBI: A crown ether that is cyclododecane in which the carbon atoms at positions 1, 4, 7 and 10 have been replaced by oxygen atoms.

Synthesis Reference(s)

Tetrahedron Letters, 15, p. 4029, 1974 DOI: 10.1016/S0040-4039(01)92075-1

General Description

12-Crown-4 is a crown ether generally used as a ligand in coordination chemistry. It is also known as lithium ionophore because of its strong chelating property specific to lithium cation.

Purification Methods

The distilled crude product has to be recrystallised from pentane at -20o to remove acyclic material. It is then dried over P2O5. It complexes Li. [Anet et al. Acta Chem Scand 27 3395 1973, Beilstein 19/11 V 334.]

12-Crown-4 Preparation Products And Raw materials

Raw materials

Preparation Products

12-Crown-4 Suppliers

Global( 200)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3620	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Xiamen AmoyChem Co., Ltd	+86-592-6051114 +8618959220845	sales@amoychem.com	China	6387	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21149	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17367	58

Supplier	Advantage
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
Shanghai Zheyan Biotech Co., Ltd.	58
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Xiamen AmoyChem Co., Ltd	58
Chongqing Chemdad Co., Ltd	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
SIMAGCHEM CORP	58

View Lastest Price from 12-Crown-4 manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-07-02	12-Crown-4 294-93-9	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2019-07-06	12-Crown-4 294-93-9	US $7.00 / kg	1kg	99%	100KG	Career Henan Chemical Co
2019-07-06	12-Crown-4 294-93-9	US $7.00 / kg	1kg	99%	100KG	Career Henan Chemical Co

12-Crown-4
294-93-9
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

12-Crown-4
294-93-9
US $7.00 / kg
99%
Career Henan Chemical Co

12-Crown-4
294-93-9
US $7.00 / kg
99%
Career Henan Chemical Co

12-Crown-4 Spectrum

12-Crown-4(294-93-9)MS 12-Crown-4(294-93-9)¹HNMR 12-Crown-4(294-93-9)¹³CNMR 12-Crown-4(294-93-9)IR1 12-Crown-4(294-93-9)Raman

294-93-9(12-Crown-4)Related Search:

1,7-DIAZA-12-CROWN-4,4,10-DIAZA-12-CROWN 4-ETHER BIS[(12-CROWN-4)METHYL] DODECYLMETHYLMALONATE 2-(HYDROXYMETHYL)-12-CROWN 4-ETHER Tetraaza 12-crown-4 1-AZA-12-CROWN 4-ETHER,1-AZA-12-CROWN-4,AZA-12-CROWN-4,aza-12-crown-499.5+%

BENZO-12-CROWN-4,BENZO-12-CROWN 4-ETHER,Benzo-12-crown-4, 99+%,BENZO-12-CROWN-4 98+% 1-aza-12-crown-5 TETRAAZA-12-CROWN-4-1,4,7,10-TETRAACETIC ACID,TETRAAZA-12-CROWN-4 TETRAACETIC ACID AMMONIUM SALT (SEE 2923) TETRAAZA-12-CROWN-4 TETRAHYDROCHLORIDE CYCLODODECANE

N-METHYLAZA-12-CROWN-4 4-TERT-BUTYL-CALIX[4]ARENE-CROWN-4-COMPLEX 1-BENZYL-1-AZA-12-CROWN-4,N-BENZYLAZA-12-CROWN-4 TETRAAZA-12-CROWN-4 TETRAHYDROGENSULFATE 12-Crown-4

Cyclohexyl-12-crown-4 Tetraaza 12-crown-4-tetraacetic acid derivative BIS[(12-CROWN-4)METHYL] 2,2-DIDODECYLMALONATE

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LITHIUM IONOPHORE V CROWN ETHER/12-CROWN-4 Eoct Ethylene oxide cyclic tetramer 1,4,7,10-TETRAOXYCYCLODODECANE 12-CROWN-4 1,4,7,10-Tetraoxacyclododecane, 12-Crown-4 12-Crown-4,97% CROWN ETHER/12-CROWN-4 FOR SYNTHESIS 12-Crown-4 Cyclic tetraMer of ethylene oxide which is specific for the lithiuM cation., 98% 12-Crown-4(1,4,7,10-Tetraoxacyclododecane) 12-Crown 4-Ether > 294-93-9 12-Crown-4 Crown 1,4,7,10-TETRAOXACYCLODODECANE 12-CROWN 4-ETHER 12 C 4 12C4 12-C-4 294-93-9 294-93-6 Chelation/Complexation Compounds Macrocycles for Host-Guest Chemistry Crown Ethers Synthetic Reagents Crown Ethers Functional Materials Macrocycles for Host-Guest Chemistry