Vanadinocene Dichloride
- CAS No.
- 12083-48-6
- Chemical Name:
- Vanadinocene Dichloride
- Synonyms
- dichlorovanadocene;VANADOCENE CHLORIDE;VANADOCENE DICHLORIDE;VANADINOCENE DICHLORIDE;Cyclopentane Dichlorovanadium;Dicyclopentadienyldichlorovanadium;Dicyclopentadienevanadium dichloride;Dichlorobis(cyclopentadienyl)vanadium;dichlorodi-pi-cyclopentadienyl-vanadiu;dichlorodi-pi-cyclopentadienylvanadium
- CBNumber:
- CB8763194
- Molecular Formula:
- C10H10Cl2V10*
- Molecular Weight:
- 252.03
- MDL Number:
- MFCD00014260
- MOL File:
- 12083-48-6.mol
| Melting point | 182-194 °C (dec.)(lit.) |
|---|---|
| Density | 1,6 g/cm3 |
| storage temp. | 2-8°C |
| solubility | soluble in H2O, chloroform, ethanol |
| form | crystal |
| Specific Gravity | 1.6 |
| color | green |
| Water Solubility | Reacts with water |
| Sensitive | Air & Moisture Sensitive |
| Exposure limits | NIOSH: Ceiling 0.05 mg/m3 |
| CAS DataBase Reference | 12083-48-6(CAS DataBase Reference) |
| FDA UNII | 4W2E0IDO21 |
| EPA Substance Registry System | Vanadocene dichloride (12083-48-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H319-H335 | |||||||||
| Precautionary statements | P280a-P301+P310a-P405-P501a-P261-P301+P310-P305+P351+P338 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25-36/37/38 | |||||||||
| Safety Statements | 26-28-36/37/39-45 | |||||||||
| RIDADR | UN 3285 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | YW1580000 | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29310099 | |||||||||
| NFPA 704 |
|
Vanadinocene Dichloride price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | V0090 | Vanadinocene Dichloride >98.0%(T) | 12083-48-6 | 1g | $198 | 2023-06-20 | Buy |
| Alfa Aesar | 039588 | Bis(cyclopentadienyl)vanadium dichloride, 95% | 12083-48-6 | 1g | $61.5 | 2021-12-16 | Buy |
| Strem Chemicals | 23-0200 | Bis(cyclopentadienyl)vanadium dichloride (Vanadocene dichloride), 95% | 12083-48-6 | 1g | $97 | 2024-03-01 | Buy |
| Strem Chemicals | 23-0200 | Bis(cyclopentadienyl)vanadium dichloride (Vanadocene dichloride), 95% | 12083-48-6 | 5g | $379 | 2024-03-01 | Buy |
| Strem Chemicals | 23-0200 | Bis(cyclopentadienyl)vanadium dichloride (Vanadocene dichloride), 95% | 12083-48-6 | 25g | $1499 | 2024-03-01 | Buy |
Vanadinocene Dichloride Chemical Properties,Uses,Production
Chemical Properties
dark green crystalline powder
Uses
Bis(cyclopentadienyl)vanadium(IV) dichloride is a catalyst for solvent free, room temperature preparation of vicinal amino alcohols as fungistatic agents, catalyst fot oligomerization reactions via the Aufbau propagation reaction and as a catalyst for aqueous polymerization reactions using oxygen as a co catalyst. It is used as a catalyst for dl-selective pinacol-type coupling reactions, as an affecter of crystal growth of calcium carbonate and and as an inhibitor of human topoisomerase II enzyme with antitumor activity.
Uses
Vanadocene dichloride is used like other metallocenes as a catalyst, ultraviolet absorber, reducing agent, free radical scavenger, antiknock agent in gasoline, and as a developmental anticancer drug.
General Description
Pale green crystals or green powder.
Air & Water Reactions
Extremely sensitive to exposure to air. Also extremely sensitive to moisture; decomposes in water
Reactivity Profile
Organometallics, such as BIS(CYCLOPENTADIENYL)VANADIUM DICHLORIDE, are reactive with many other groups. Incompatible with acids and bases. Organometallics are good reducing agents and therefore incompatible with oxidizing agents. Often reactive with water to generate toxic or flammable gases. Organometallics containing halogens (fluorine, chlorine, bromine, iodine) bonded to the metal typically with generate gaseous hydrohalic acids (HF, HCl, HBr, HI) with water.
Fire Hazard
Flash point data for BIS(CYCLOPENTADIENYL)VANADIUM DICHLORIDE are not available. BIS(CYCLOPENTADIENYL)VANADIUM DICHLORIDE is probably combustible.
Pharmaceutical Applications
Vanadocene dichloride [(η5-C5H5)2VCl2, dichloro bis(η5-cyclopentadienyl)vanadium(IV)] is structurally very similar to Cp2TiCl2. It also consists of a metal centre with an oxidation number of +IV, in this case vanadium, and two Cp and two chloride ligands. Vanadocene dichloride is a 17-electron complex containing an unpaired electron and is therefore paramagnetic. Vanadocene dichloride has found application as a catalyst for polymerisation reactions, but was also intensively studied as an anticancer agent in parallel to Cp2TiCl2 because of their structural similarities. Vanadocene dichloride has proven to be even more effective than its titanium analogue as an antiproliferative agent against both animal and human cell lines in preclinical testing.
Pharmaceutical Applications
Vanadocene dichloride [( η5-C5H5)2VCl2, dichloro bis(η5-cyclopentadienyl)vanadium(IV)] is structurally very similar to Cp2TiCl2. It also consists of a metal centre with an oxidation number of +IV, in this case vanadium, and two Cp and two chloride ligands. Vanadocene dichloride is a 17-electron complex containing an unpaired electron and is therefore paramagnetic .
Vanadocene dichloride has found application as a catalyst for polymerisation reactions, but was also intensively studied as an anticancer agent in parallel to Cp2TiCl2 because of their structural similarities. Vanadocene dichloride has proven to be even more effective than its titanium analogue as an antiproliferative agent against both animal and human cell lines in preclinical testing. The main problems are the difficult characterisation of the active vanadium compounds and their fast hydrolysis.
Vanadinocene Dichloride Preparation Products And Raw materials
Vanadinocene Dichloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Xi'an MC Biotech, Co., Ltd. | 029-89275612 +8618991951683 | mcbio_sales@163.com | China | 2255 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9231 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503259 +86-19930503259 | cherry@crovellbio.com | China | 18455 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178 +86-85511178 | peter68@ptchemgroup.com | China | 35453 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 50000 | 58 |