Squalene
- CAS No.
- 111-02-4
- Chemical Name:
- Squalene
- Synonyms
- Supraene;SQUALENE OIL;trans-squalene;(E,E,E,E)-Squalene;Squalen;All-trans-Squalene;AddaVax;squalcnc;Spinacen;SPINACENE
- CBNumber:
- CB8855316
- Molecular Formula:
- C30H50
- Molecular Weight:
- 410.72
- MDL Number:
- MFCD00008912
- MOL File:
- 111-02-4.mol
| Melting point | −75 °C(lit.) |
|---|---|
| Boiling point | 285 °C25 mm Hg(lit.) |
| Density | 0.858 g/mL at 25 °C(lit.) |
| vapor pressure | 0Pa at 25℃ |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | 2-8°C |
| solubility | DMSO : 16.67 mg/mL (40.59 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble) |
| form | liquid |
| color | light yellow |
| Odor | oil, faint odor |
| Water Solubility | <0.1 g/100 mL at 19 ºC |
| Merck | 14,8768 |
| BRN | 1728919 |
| LogP | 14.12 at 24℃ |
| CAS DataBase Reference | 111-02-4(CAS DataBase Reference) |
| FDA UNII | 7QWM220FJH |
| NIST Chemistry Reference | 2,6,10,14,18,22-Tetracosahexaene, 2,6,10,15,19,23-hexamethyl-, (all-E)-(111-02-4) |
| EPA Substance Registry System | Squalene (111-02-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H304 | |||||||||
| Precautionary statements | P301+P310+P331 | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | XB6010000 | |||||||||
| F | 8-10-23 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29012980 | |||||||||
| Toxicity | mouse,LD50,intravenous,1800mg/kg (1800mg/kg),Japanese Journal of Cancer Research. Vol. 76, Pg. 1021, 1985. | |||||||||
| NFPA 704 |
|
Squalene price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S3626 | Squalene ≥98%, liquid | 111-02-4 | 10ml | $59.3 | 2024-03-01 | Buy |
| Sigma-Aldrich | Y0002131 | Squalene European Pharmacopoeia (EP) Reference Standard | 111-02-4 | Y0002131 | $156 | 2024-03-01 | Buy |
| Sigma-Aldrich | S3626 | Squalene ≥98%, liquid | 111-02-4 | 1l | $882 | 2024-03-01 | Buy |
| Sigma-Aldrich | 442785 | Squalene analyticalstandard | 111-02-4 | 1000mg | $303 | 2024-03-01 | Buy |
| TCI Chemical | H0097 | Squalene >98.0%(GC) | 111-02-4 | 25mL | $21 | 2024-03-01 | Buy |
Squalene Chemical Properties,Uses,Production
Chemical Properties
clear colourless to faint yellow oil
Uses
cosmetic and pharmaceutical excipient
Uses
Squalene is a natural triterpene that plays an important role in the synthesis of cholesterol, steroid hormones, and vitamin D in the human body. Squalene is commonly used as a biochemical precursor i n the preparation of steroids. Squalene is also a natural moisturizer with low acute toxicity and is not significant human skin irritants or sensitizers.
Uses
Bactericide; intermediate in manufacture of pharmaceuticals, organic coloring materials, rubber chemicals, aromatics and surface active agents.
Production Methods
Squalene is extracted from shark liver or synthesized from hexaphenyl-1,4-butanediyldiphosphonium dibromide and 6,10-dimethyl-5,9-undecadien-2-one (geranylacetone, industrial intermediate in the vitamin E synthesis).
Definition
ChEBI: A triterpene consisting of 2,6,10,15,19,23-hexamethyltetracosane having six double bonds at the 2-, 6-, 10-, 14-, 18- and 22-positions with (all-E)-configuration.
General Description
Clear, slightly yellow liquid with a faint odor. Density 0.858 g / cm3.
Air & Water Reactions
May become discolored on exposure to air. Insoluble in water.
Reactivity Profile
(all-E)-2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexaene is incompatible with strong oxidizing agents. .
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition (all-E)-2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexaene emits toxic fumes of carbon monoxide and carbon dioxide.
Fire Hazard
(all-E)-2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexaene is probably combustible.
Flammability and Explosibility
Non flammable
Biochem/physiol Actions
Squalene is a biosynthetic precursor to all steroids. It acts as a cytoprotective agent to normal cells exposed to carcinogens and antitumor agents. Squalene helps in equalizing the blood cholesterol levels. It increases the production of HDL (high density lipoprotein) and the excretion of LDL (low density lipoprotein). This helps in reducing the risk of heart disease and protects the less stable body fats from oxidation. It is also used in treating hypercholesterolemia. Squalene is known to improve the efficiency of cholesterol lowering drugs. It also serves as an antioxidant by preventing the effects of free radical. It protects skin from drying and other environmental conditions such as oxidation, ultraviolet rays and pollutants. Squalene is known to promote wound healing.
target
COX | STAT | FOXP3 | Nrf2 | SOD | GPx
Squalene Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 1000 | 58 |
| BINBO BIOLOGICAL CO.,LTD | +8618629063126 | info@binbobiological.com | China | 326 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
View Lastest Price from Squalene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-23 | Vegan Squalene
111-02-4
|
US $0.00 / kg | 1kg | 50% 70% 80% | 1000 kg | BINBO BIOLOGICAL CO.,LTD | |
 |
2024-04-12 | Squalene
111-02-4
|
US $0.00 / kg | 1kg | 99% | 2000ton | Shaanxi Haibo Biotechnology Co., Ltd | |
 |
2023-11-09 | Squalene
111-02-4
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd |
-
- Vegan Squalene
111-02-4
- US $0.00 / kg
- 50% 70% 80%
- BINBO BIOLOGICAL CO.,LTD
-
- Squalene
111-02-4
- US $0.00 / kg
- 99%
- Shaanxi Haibo Biotechnology Co., Ltd
-
- Squalene
111-02-4
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd