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(-)-Gossypol

(-)-Gossypol Structure
(-)-Gossypol structure
CAS No.
90141-22-3
Chemical Name:
(-)-Gossypol
Synonyms
CS-619;C:C&B61;(R)-Gossypol;(-)-Gossypol;AT 101, >=98%;GOSSYPOL，AT101;(R)-(-)-Gossypol;GOSSYPOL 90141-22-3;(-)-Gossypol USP/EP/BP;DL-gossypol acetic acid
CBNumber:
CB91437592
Molecular Formula:
C30H30O8
Molecular Weight:
518.55
MDL Number:
MFCD00017352
MOL File:
90141-22-3.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59
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(-)-Gossypol Properties

Melting point 166-167℃
alpha D28 -386 to -390° (c = 0.5 g/100 g soln in CHCl3)
Boiling point 707.9±55.0 °C(Predicted)
Density 1.403
storage temp. -20°C
solubility DMSO: soluble15mg/mL, clear
form powder
pka 7.15±0.50(Predicted)
color white to light brown
optical activity [α]/D -350 to -365°, c = 0.3 (CDCl3)
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
FDA UNII 8DY2X8LXW4
NCI Drug Dictionary R-(-)-gossypol acetic acid

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
WGK Germany  3

(-)-Gossypol price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC A790545 AT101 90141-22-3 5mg $130 2021-12-16 Buy
BroadPharm BP-25397 AT101 98% 90141-22-3 25mg $200 2021-12-16 Buy
ApexBio Technology A3196 AT-101 90141-22-3 10mg $105 2021-12-16 Buy
BroadPharm BP-25397 AT101 98% 90141-22-3 50mg $300 2021-12-16 Buy
ApexBio Technology A3196 AT-101 90141-22-3 50mg $330 2021-12-16 Buy
Product number Packaging Price Buy
A790545 5mg $130 Buy
BP-25397 25mg $200 Buy
A3196 10mg $105 Buy
BP-25397 50mg $300 Buy
A3196 50mg $330 Buy

(-)-Gossypol Chemical Properties,Uses,Production

Description

AT-101 (90141-22-3) is a small molecule mimic of the BH3 domain of cellular Bcl-2 inhibitors which interferes with the function of Bcl-2-family antiapoptotic proteins. AT-101 induces apoptosis in drug-resistant multiple myeloma cell lines. Apoptosis is activated by the mitochondrial pathway. Cell permeable.

Uses

AT-101 is a BH3 mimetic known to be a potent inhibitor of antiapoptotic Bcl-2 family members.

Biological Activity

R-(-)-enantiomer of gossypol (Gossypol). Mimics the BH3 domains of Bcl-2, Bcl-XL and Mcl-1. Disrupts heterodimerization of Bcl-2 with proapoptotic family members. Induces apoptosis in vitro through activation of caspase-9; cytotoxic to multiple myeloma and drug-resistant cell lines. Delays onset of androgen-independent growth of VCaP prostate cancer xenografts in vivo .

Biochem/physiol Actions

AT101 [R-(-)-enantiomer of gossypol] is an orally available and well-tolerated natural BH3-mimetic that activates Bax and also induces mitochondrial Smac release. AT101 has shown anti-tumor activity as a single agent and in combination with standard anticancer drugs in a variety of tumor models. AT101 induced apoptosis in chemoresistant ovarian cancer cells.

storage

Store at -20°C

References

1) Kline et al. (2008), R-(-)-gossypol (AT-101) activates programmed cell death in multiple myeloma cells; Exp. Hematol., 36 568 2) Balakrishnan et al. (2009), AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance; Blood, 113 149

(-)-Gossypol Preparation Products And Raw materials

Raw materials

Preparation Products

(-)-Gossypol Suppliers

Global( 56)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai UCHEM Inc. 		+862156762820 +86-13564624040 sales@myuchem.com China 6710 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-89586680 +86-18192503167 1026@dideu.com China 9271 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 29067 58
AFINE CHEMICALS LIMITED 		0571-85134551 info@afinechem.com CHINA 15377 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
Henan Aochuang Chemical Co.,Ltd. 		+86-0371-63689365 +8618638391208 sales@aochuangchem.com China 9425 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131981 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2923 55
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15848 69
Supplier Advantage
Shanghai UCHEM Inc. 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Dideu Industries Group Limited 		58
AFINE CHEMICALS LIMITED 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
Henan Aochuang Chemical Co.,Ltd. 		58
TargetMol Chemicals Inc. 		58
Amadis Chemical Company Limited 		58
Shanghai Boyle Chemical Co., Ltd. 55
3B Pharmachem (Wuhan) International Co.,Ltd. 69

View Lastest Price from (-)-Gossypol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(-)-Gossypol pictures 2024-04-17 (-)-Gossypol
90141-22-3
 US $1.10 / g 1g 99.0% min 100 tons min Shaanxi Dideu Medichem Co. Ltd
(-)-Gossypol pictures 2022-09-23 (-)-Gossypol
90141-22-3
 US $0.00-0.00 / kg 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
(-)-Gossypol USP/EP/BP pictures 2021-06-02 (-)-Gossypol USP/EP/BP
90141-22-3
 US $1.10 / g 1g 99.9% 100Tons min Dideu Industries Group Limited
  • (-)-Gossypol pictures
  • (-)-Gossypol
    90141-22-3
  • US $1.10 / g
  • 99.0% min
  • Shaanxi Dideu Medichem Co. Ltd
  • (-)-Gossypol pictures
  • (-)-Gossypol
    90141-22-3
  • US $0.00-0.00 / kg
  • 98%
  • Henan Aochuang Chemical Co.,Ltd.

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AT 101, >=98% DL-gossypol acetic acid (R)-(-)-Gossypol (R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-8,8'-dicarboxaldehyde (R)-Gossypol R-(-)-gossypol acetic acid GOSSYPOL 90141-22-3 CS-619 (R)-(-)-GOSSYPOL;R-(-)-GOSSYPOL ACETIC ACID C:C&B61 [2,2'-Binaphthalene]-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-, (2R)- (-)-Gossypol (-)-Gossypol USP/EP/BP GOSSYPOL，AT101 90141-22-3 Inhibitors