ChemicalBook >> CAS DataBase List >>Cilazapril
Cilazapril
- CAS No.
- 88768-40-5
- Chemical Name:
- Cilazapril
- Synonyms
- Vascace;(1S,9S)-;Yipingshu;Ro34-2848;Cilazapril;Ro 31-2848;Ro 34-2848;Ro-34-2848;CILASTATIN NA;Cilazapril USP/EP/BP
- CBNumber:
- CB9307140
- Molecular Formula:
- C22H31N3O5
- Molecular Weight:
- 417.5
- MDL Number:
- MFCD00865788
- MOL File:
- 88768-40-5.mol
Last updated:2023-05-18 11:30:59
| Melting point | 95-97°C |
|---|---|
| Boiling point | 598.1±60.0 °C(Predicted) |
| Density | 1.26±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly) |
| form | powder |
| pka | 2.28±0.20(Predicted) |
| color | White to Off-White |
| CAS DataBase Reference | 88768-40-5(CAS DataBase Reference) |
| FDA UNII | 8Q9454114Q |
| ATC code | C09AA08 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| RTECS | MJ9650200 |
Cilazapril price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29777 | Cilazapril | 88768-40-5 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 29777 | Cilazapril | 88768-40-5 | 5mg | $78 | 2024-03-01 | Buy |
| Cayman Chemical | 29777 | Cilazapril | 88768-40-5 | 10mg | $122 | 2024-03-01 | Buy |
| Cayman Chemical | 29777 | Cilazapril | 88768-40-5 | 25mg | $267 | 2024-03-01 | Buy |
| TRC | C441200 | Cilazapril | 88768-40-5 | 25mg | $290 | 2021-12-16 | Buy |
Cilazapril Chemical Properties,Uses,Production
Description
Cilazapril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor cilazaprilat. In vivo, cilazapril (0.1 mg/kg) inhibits plasma ACE activity and inhibits the angiotensin I-induced pressor response in anesthetized rats and cats. It decreases systolic blood pressure in spontaneously hypertensive rats when administered at a dose of 30 mg/kg. Cilazapril (10 mg/kg, p.o.) decreases blood pressure in volume-depleted renal hypertensive dogs. Formulations containing cilazapril have been used in the treatment of hypertension.
Chemical Properties
Off-White Solid
Uses
An ACE inhibitor. Hydrolyzed in vivo to the active diacid metabolite (Cilazaprilat). Antihypertensive.
Definition
ChEBI: Cilazapril is a pyridazinodiazepine resulting from the formal condensation of the carboxy group of cilazaprilat with ethanol. It is a drug used in the treatment of hypertension and heart failure. It has a role as a prodrug, an antihypertensive agent and an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor. It is an ethyl ester, a pyridazinodiazepine and a dicarboxylic acid monoester. It is functionally related to a Cilazaprilat.
brand name
Inhibace (Hoffmann-LaRoche).
Cilazapril Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 83)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9271 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29067 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9339 | 58 |
| Hu Bei Jiutian Bio-medical Technology CO.,Ltd | 027-88013699 17354350817 | Ryan@jiutian-bio.com | China | 7433 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
View Lastest Price from Cilazapril manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-08-11 | Cilazapril USP/EP/BP
88768-40-5
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited | |
 |
2021-07-13 | Cilazapril
88768-40-5
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-10 | Cilazapril
88768-40-5
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Cilazapril USP/EP/BP
88768-40-5
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- Cilazapril
88768-40-5
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Cilazapril
88768-40-5
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
88768-40-5(Cilazapril)Related Search:
CILAZAPRIL EPC(CRM STANDARD),CILAZAPRIL EPC(
DELAPRIL
Lithium diisopropylamide
DIAZOXIDE
Carbonyl iron powder
NITROUS OXIDE
Ethyl N-(2-butyl)glycinate
2,2'-(ETHYLENEDIIMINO)-DIBUTYRIC ACID
Cilastatin
Cilazaprilat
1of4
6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid, 9-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-, (1S,9S)-
6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid, 9-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-, [1S-[1α,9α(R*)]]-
Ro 31-2848
Yipingshu
CILASTATIN NA
CILASTATIN SODIUM SALT
sodium hydrogen 7-[(2-amino-2-carboxylatoethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]hept-2-enoate
(1S,9S)-9-[(S)-1-Ethoxycarbonyl-3-phenylpropylamino]-10-oxoperhydropyridazino[1,2-a][1,2]diazepine-1-carboxylic acid
Cilazapril
(1S,9S)-9-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-α][1,2]diazepine-1-carboxylic Acid
Vascace
(1S,9S)-9-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-10-oxooctahydro-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid
(1S,9S)-9-[[(S)-1-Ethoxycarbonyl-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid
(1S,9S)-
(1S,9S)-9-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic Acid
Cilazapril USP/EP/BP
Cilazapril (anhydrous)
Ro 34-2848
Ro-34-2848
Ro34-2848
88768-40-5
Chiral Reagents
API
Intermediates & Fine Chemicals
Pharmaceuticals