CHLOROTRIANISENE | 569-57-3

CHLOROTRIANISENE Properties

Melting point	114-116°
Boiling point	496.07°C (rough estimate)
Density	1.1010 (rough estimate)
refractive index	1.4585 (estimate)
storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	insoluble in H2O; insoluble in EtOH; ≥16.1 mg/mL in DMSO
form	solid
EWG's Food Scores	1
NCI Dictionary of Cancer Terms	TACE
FDA UNII	6V5034L121
ATC code	G03CA06
Proposition 65 List	Chlorotrianisene
EPA Substance Registry System	Chlorotrianisene (569-57-3)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS08

Signal word

Danger

WGK Germany

3

RTECS

KV0600000

NFPA 704

	0
2		0

CHLOROTRIANISENE price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	384536	TACE	569-57-3	96Tests	$729	2021-12-16	Buy
ApexBio Technology	B5912	Chlorotrianisene	569-57-3	25mg	$1200	2021-12-16	Buy
American Custom Chemicals Corporation	API0001964	CHLOROTRIANISENE 95.00%	569-57-3	25G	$3335.06	2021-12-16	Buy
Biorbyt Ltd	orb529241	ADAM17	569-57-3	10μg	$387.6	2021-12-16	Buy
ChemScene	CS-0020308	Chlorotrianisene	569-57-3	10mg	$250	2021-12-16	Buy

Product number	Packaging	Price	Buy
384536	96Tests	$729	Buy
B5912	25mg	$1200	Buy
API0001964	25G	$3335.06	Buy
orb529241	10μg	$387.6	Buy
CS-0020308	10mg	$250	Buy

CHLOROTRIANISENE Chemical Properties,Uses,Production

Originator

TACE,Merrell ,US ,1952

Uses

Estrogen.

Uses

Chlorotrianisene USP (TACE) is used to treat Androgen dependent carcinoma of the prostate.

Definition

ChEBI: Chlorotrianisene is a chloroalkene. It has a role as an estrogen receptor modulator, an antineoplastic agent and a xenoestrogen. It derives from a hydride of a stilbene.

Manufacturing Process

The following method is described in US Patent 2,430,891. To a solution of 10 parts of tris-p-methoxyphenyl ethylene in 35 to 40 parts of carbon tetrachloride is added a solution of 2.0 parts of chlorine in 50 parts of carbon tetrachloride, with stirring, and over a period of ? hour. The carbon tetrachloride is then removed by distillation on a steam bath and the residual oil is recrystallized from 250 to 400 parts of methanol, decolorizing with charcoal or the like if necessary. Tris-p-methoxyphenyl chloroethylene is obtained in a yield of 65 to 75%. It melts at 113° to 114°C.

brand name

Tace (Sanofi Aventis).

Therapeutic Function

Estrogen

General Description

Small white crystals or white powder. Softens at 226°F. Odorless.

Air & Water Reactions

Sensitive to prolonged exposure to air and light. Insoluble in water.

Reactivity Profile

CHLOROTRIANISENE may react vigorously with strong oxidizing agents. Can react exothermically with reducing agents (such as alkali metals and hydrides) to release gaseous hydrogen. May react exothermically with both acids and bases. Various catalysts (such as acids) or initiators can cause very exothermic addition polymerization reactions.

Fire Hazard

Flash point data for CHLOROTRIANISENE are not available. CHLOROTRIANISENE is probably combustible.

Biological Activity

ed50: 2.0 μmglandular kallikrein, a trypsin-like serine protease, has been identified as a major estrogen-induced protein in the rat anterior pituitary. this induction appears to be mediated by increased gene expression since glandular kallikrein mrna is also estrogen-induced. chlorotrianisene is classified as an estrogen agonist.

in vitro

the ed50 of chlorotrianisene were lowered by 3.9-fold. chlorotrianisene inhibited the growth of both p388 and p388/adr cells in a concentration-dependent manner [1].

in vivo

chlorotrianisene markedly varied in its ability to elicit agonist responses on the three measures. on uterine weight and anterior pituitary prolactin, chlorotrianisene behaved as partial agonists. chlorotrianisene also exhibited strikingly less agonist activity on glandular kallikrein than on prl or the uterus. further, the small agonist activity of chlorotrianisene on glandular kallikrein induction differed from that on the uterus or prolactin [2].

References

[1] ramu a, glaubiger d, fuks z. reversal of acquired resistance to doxorubicin in p388 murine leukemia cells by tamoxifen and other triparanol analogues. cancer res. 1984 oct;44(10):4392-5.
[2] powers ca, hatala ma, pagano pj. differential responses of pituitary kallikrein and prolactin to tamoxifen and chlorotrianisene. mol cell endocrinol. 1989 sep;66(1):93-100.
[3] nulsen ro, carmon wb, hendrick ho. tace (chlorotrianisene), a new estrogen for inhibition of lactation. am j obstet gynecol. 1953 may;65(5):1048-51.

CHLOROTRIANISENE Preparation Products And Raw materials

Raw materials

4'-Methoxyacetophenone Grignard reagent Styrene Anisole Chloroacetyl chloride

Anisic acid

1of2

Preparation Products

CHLOROTRIANISENE Suppliers

Global( 99)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29016	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	CHINA	52867	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Shaanxi Didu New Materials Co. Ltd	+86-89586680 +86-13289823923	1026@dideu.com	China	9116	58
ZHEJIANG JIUZHOU CHEM CO., LTD	+86-0576225566889 +86-13454675544	admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com	China	20000	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	50000	58

Supplier	Advantage
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Chongqing Chemdad Co., Ltd	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
InvivoChem	58
Shaanxi Didu New Materials Co. Ltd	58
ZHEJIANG JIUZHOU CHEM CO., LTD	58
GIHI CHEMICALS CO.,LIMITED	58

View Lastest Price from CHLOROTRIANISENE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-06-03	CHLOROTRIANISENE USP/EP/BP 569-57-3	US $1.10 / g	1g	99.9%	100 Tons Min	Dideu Industries Group Limited
	2019-07-06	CHLOROTRIANISENE 569-57-3	US $1.00 / KG	1G	98%	100KG	Career Henan Chemical Co

CHLOROTRIANISENE USP/EP/BP
569-57-3
US $1.10 / g
99.9%
Dideu Industries Group Limited

CHLOROTRIANISENE
569-57-3
US $1.00 / KG
98%
Career Henan Chemical Co

CHLOROTRIANISENE Spectrum

CHLOROTRIANISENE(569-57-3)¹HNMR

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Anti-ADAM 17 (Cleaved-Arg215) antibody produced in rabbit 1,1',1''-(2-Chloro-1,1,2-ethenetriyl)tris(4-methoxybenzene) 1,1',1''-(1-Chloro-1-ethenyl-2-ylidene)-tris(4-methoxybenzene) 1,1',1(1-Chloro-1-ethenyl-2-ylidene)tris[4-methoxybenzene] 1,1,1’’-(1-Chloro-1-ethenyl-2-ylidene)tris[4-methoxy-benzene] CHLOROTRIANISENE chlorotris(4-methoxyphenyl)ethylene Chlortrianisoestrol 1,1',1''-(1-Chloro-1,2,2-ethenetriyl)tris[4-methoxybenzene] 1-Chloro-1,2,2-tris(4-methoxyphenyl)ethene 1-[2-chloro-1,2-bis(4-methoxyphenyl)ethenyl]-4-methoxybenzene 1-[2-chloro-1,2-bis(4-methoxyphenyl)ethenyl]-4-methoxy-benzene Chlorotrianisene (1 g) ADA17 ADAM 17 Anti-ADAM 17, C-Terminal antibody produced in rabbit CD156b antigen CSVP CD156b Disintegrin and metalloproteinase domain-containing protein 17 1,1’,1’’-(1-chloro-1-ethenyl-2-ylidene)tris(4-methoxy)-benzen 1,1’,1’’-(1-chloro-1-ethenyl-2-ylidene)tris(4-methoxy-benzen 1,1’,1’’-(1-chloro-1-ethenyl-2-ylidene)-tris(4-methoxybenzene) 1,1’,1’’-(1-chloro-1-ethenyl-2-ylidene)tris[4-methoxybenzene] 1-[2-Chloro-1,2-bis(4-methoxyphenyl)vinyl]-4-methoxybenzene Anisene Benzene, 1,1',1''-(1-chloro-1-ethenyl-2-ylidene)tris*4-methoxy- Benzene, 1,1',1''-(1-chloro-1-ethenyl-2-ylidene)tris[4-methoxy- Chloortrianisestrol Chlorestrolo chlorotrianisenecrystalline Chlorotrianisine Chlorotrianizen chlorotris(p-methoxyphenyl)-ethylen Chlorotris(p-methoxyphenyl)ethylene Chlorotrisin Chlortrianisen Chlortrianisestrol Chlortrianizen Clorestrolo Clorotrisin Ethylene, chlorotris(p-methoxyphenyl)- Hormonisene Khlortrianizen Merbentul Metace Nsc-10108 Rianil Tace Tace-fn Trianisestrol Tri-p-anisylchloroethylene Tris(p-methoxyphenyl)chloroethylene Tris-(p-methoxyphenyl)ethylene Chlorotrianisene-d9 4,4',4''-(2-chloroethene-1,1,2-triyl)tris(Methoxybenzene) Snake venom-like protease TACE, human