ChemicalBook >> CAS DataBase List >>2'-Deoxyadenosine monohydrate
2'-Deoxyadenosine monohydrate
- CAS No.
- 16373-93-6
- Chemical Name:
- 2'-Deoxyadenosine monohydrate
- Synonyms
- 2-DEOXYADENOSINE MONOHYDRATE;2′-Da;Adenyldeoxy;2'-Deoxyadenosine mo;ADENINE DEOXYRIBOSIDE;2'-DEOXYADENOSINE:H2O;DEOXYADENOSINE HYDRATE;2'-Deoxy-adenosine ,98%;2-DEOXYADENOSINE H2O D2;2-deoxyadenosine 99-100%
- CBNumber:
- CB9375521
- Molecular Formula:
- C10H15N5O4
- Molecular Weight:
- 269.26
- MDL Number:
- MFCD00149364
- MOL File:
- 16373-93-6.mol
- MSDS File:
- SDS
Last updated:2024-04-22 18:05:02
| Melting point | 187-189 °C |
|---|---|
| refractive index | -25.5 ° (C=0.5, H2O) |
| storage temp. | 2-8°C |
| solubility | H2O: soluble50mg/mL, clear, colorless |
| form | powder |
| color | White to light beige |
| Water Solubility | 0.3 g/100 mL (20 ºC) |
| BRN | 5191174 |
| Stability | Stable, but air sensitive. Incompatible with strong oxidizing agents. |
| InChIKey | WZJWHIMNXWKNTO-VWZUFWLJSA-N |
| CAS DataBase Reference | 16373-93-6(CAS DataBase Reference) |
| FDA UNII | F79D3BS9UH |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264b-P270-P301+P312-P330-P403-P501c | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38-20/21/22 | |||||||||
| Safety Statements | 24/25-37/39-36-26 | |||||||||
| RIDADR | UN2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | AU7358600 | |||||||||
| F | 10-23 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29349990 | |||||||||
| NFPA 704 |
|
2'-Deoxyadenosine monohydrate price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D7400 | 2′-Deoxyadenosine monohydrate ≥99% | 16373-93-6 | 1g | $73.4 | 2024-03-01 | Buy |
| Sigma-Aldrich | D7400 | 2′-Deoxyadenosine monohydrate ≥99% | 16373-93-6 | 5g | $225 | 2024-03-01 | Buy |
| TCI Chemical | D0046 | 2'-Deoxyadenosine Monohydrate >99.0%(T) | 16373-93-6 | 5g | $58 | 2024-03-01 | Buy |
| TCI Chemical | D0046 | 2'-Deoxyadenosine Monohydrate >99.0%(T) | 16373-93-6 | 25g | $229 | 2024-03-01 | Buy |
| Alfa Aesar | A11166 | 2'-Deoxyadenosine monohydrate, 99% | 16373-93-6 | 1g | $39 | 2024-03-01 | Buy |
2'-Deoxyadenosine monohydrate Chemical Properties,Uses,Production
Description
2'-Deoxyadenosine monohydrate is an adenosine nucleotide, which can be synthesized by the enzyme adenosine kinase. 2'-Deoxyadenosine monohydrate is a competitive inhibitor of phosphodiesterase, which breaks down cyclic nucleotides to their corresponding monophosphate form. This leads to elevated levels of cAMP, which can cause neuronal death by apoptosis.
Chemical Properties
White crystalline powder
Uses
2'-Deoxyadenosineise is used by some cells as an energy source under energy stress conditions and to affect cAMP levels. 2'-dAdo is used in comparison studies of the functions of adenosine analogues on various biological processes.
Uses
2′-Deoxyadenosine monohydrate has been used:
- as a component for nucleoside supplementation
- as a standard for to estimate DNA global methylation rate in proliferating oil palm embryogenic suspensions
- to reverse sterile alpha motif (SAM) and histidine-aspartate (HD) domain-containing protein (SAMHD1)
- inhibition of human immunodeficiency virus (HIV-1) and hepatitis B virus (HBV)
Uses
2'-Deoxyadenosine monohydrate is used in the synthesis of 5'-modified 2'-deoxyadenosine analogues as anti-hepatitis C virus agents.
Biochem/physiol Actions
Excess 2′-deoxyadenosine gets converted to adenosine triphosphate (dATP), which inhibits ribonucleotide reductase.
Purification Methods
Purify it by recrystallisation from H2O (hydrated crystals; solubility of the monohydrate is 1.1% in H2O at 20o). It has max 258nm (pH 1), 260nm (pH 7) and 261nm (pH 13). [Ness & Fletcher J Am Chem Soc 81 4752 1959, Walker & Butler Can J Chem 34 1168 1956.] The 3',5'-O-diacetyl derivative has m 151-152o (from EtOAc/pet ether). [Beilstein 26 III/IV 3589.]
2'-Deoxyadenosine monohydrate Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 374)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing Ribio Biotech Co.,Ltd | 010-62664360 +8613328773880 | wucy@ribio.com.cn | China | 117 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
| Ouhuang Engineering Materials (Hubei) Co., Ltd | +8617702722807 | admin@hbouhuang.com | China | 2259 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1807 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 6992 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19965 | 58 |
| Yunbio Tech Co.,Ltd. | +86-010-60605551 +86-18046518538 | yunbiochem@126.com | China | 321 | 58 |
View Lastest Price from 2'-Deoxyadenosine monohydrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-22 | 2'-Deoxyadenosine monohydrate
16373-93-6
|
US $10.00 / kg | 1kg | 99.7% | 200000kg | Ouhuang Engineering Materials (Hubei) Co., Ltd | |
 |
2023-08-12 | 2'-Deoxyadenosine monohydrate
16373-93-6
|
US $80.00 / kg | 1kg | 99% | 1000tons | Henan Bao Enluo International TradeCo.，LTD | |
 |
2023-06-27 | 2'-Deoxyadenosine monohydrate
16373-93-6
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd |
-
- 2'-Deoxyadenosine monohydrate
16373-93-6
- US $10.00 / kg
- 99.7%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
-
- 2'-Deoxyadenosine monohydrate
16373-93-6
- US $80.00 / kg
- 99%
- Henan Bao Enluo International TradeCo.，LTD
-
- 2'-Deoxyadenosine monohydrate
16373-93-6
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
16373-93-6(2'-Deoxyadenosine monohydrate)Related Search:
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9-(2-Deoxy-β-D-erythro-pentofuranosyl)adenine
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Adenine Deoxyribose Hydrate
Adenyldeoxy
(2R,3S,5R)-5-(6-aMino-9H-purin-9-yl)-2-(hydroxyMethyl)tetrahydrofuran-3-ol hydrate
[8-2H]2'-deoxyadenosine Monohydrate
Adenosine, 2'-deoxy-,hydrate (1:1)
Deoxyadenosine Monohydrat
Adenine-2'-deoxyriboside
2'-Deoxyadenosine Monohydrate(2'-dA ? H?O)
2′-Deoxyadenosine,Adeninedeoxyriboside,9-β-D-2′-Deoxyribofuranosidoadenine
2'-Deoxyadenosine monohydrate, ≥99.0%(HPLC)
2'-Deoxyadenosine 1-hydrate
2'-Deoxyadenosine Monohydrate>
2'-Deoxyadenosine monohydrate USP/EP/BP
2-DEOXYADENOSINE H2O D2
2''-Deoxy-β-D-adenosine Monohydrate
2-DEOXYADENOSINE MONOHYDRATE
16373-93-6
2'-Deoxyadenosine Monohydrate, ≥ 99.0%
2'-Deoxyadenosine monohydrate(2'-dA.H2O)
2'-Deoxyadenosine monohydrate
16373-93-6
47810-77-9
C10H13N5O3xH2O
C10H13N5O3H2O
AMINE
Nucleoside Analogs
Nucleosides, Nucleotides, Oligonucleotides
Nucleosides
Biochemicals and Reagents
BioChemical