NOVOBIOCIN SODIUM SALT
- CAS No.
- 1476-53-5
- Chemical Name:
- NOVOBIOCIN SODIUM SALT
- Synonyms
- NOVOBIOCIN SODIUM;ALBAMYCIN;U-6591;Albadry;NSC 2382;Robicina;Vulcamycin;Albycin sodium;STREPTONIVICIN;MSRV Selective
- CBNumber:
- CB9493214
- Molecular Formula:
- C31H37N2NaO11
- Molecular Weight:
- 636.63
- MDL Number:
- MFCD30207859
- MOL File:
- 1476-53-5.mol
Melting point | 215-220 C |
---|---|
alpha | D24 -38° (c = 2.5 in 95% ethanol); D24 -33° (c = 2.5 in water) |
storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
solubility | H2O: soluble50mg/mL |
form | White to yellow solid |
color | white to faintly beige |
PH | 7.5 (100g/l, H2O, 25℃) |
optical activity | [α]20/D 48±3°, c = 1% in ethanol |
Water Solubility | Soluble in water at 100mg/ml. Also soluble in ethanol or DMSOSoluble in water, ethanol, dimethyldulfoxide and methanol. |
Merck | 13,6755 |
BRN | 3892910 |
Stability | Hygroscopic |
FDA UNII | Q9S9NQ5YIY |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302-H317-H319 | |||||||||
Precautionary statements | P261-P264-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
Hazard Codes | Xi,Xn | |||||||||
Risk Statements | 43-36-36/37/38-20/21/22 | |||||||||
Safety Statements | 36-36/37-26-37/39 | |||||||||
WGK Germany | 2 | |||||||||
RTECS | RD5425000 | |||||||||
F | 8-10 | |||||||||
HS Code | 2941 90 00 | |||||||||
Toxicity | LD50 orally in Rabbit: 3500 mg/kg | |||||||||
NFPA 704 |
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NOVOBIOCIN SODIUM SALT price More Price(32)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 491207 | Novobiocin, Sodium Salt - CAS 1476-53-5 - Calbiochem Novobiocin, Sodium Salt, CAS 1476-53-5, is a DNA gyrase inhibitor that is used for the production of positively supercoiled plasma DNA. Inhibits retrovirus RNA-dependent DNA polymerases. | 1476-53-5 | 10g | $289 | 2024-03-01 | Buy |
Sigma-Aldrich | 46531 | Novobiocin sodium salt VETRANAL | 1476-53-5 | 250mg | $101 | 2024-03-01 | Buy |
Sigma-Aldrich | 1.09874 | MSRV Selective supplement | 1476-53-5 | 10vial | $204 | 2024-03-01 | Buy |
Sigma-Aldrich | 491207 | Novobiocin, Sodium Salt - CAS 1476-53-5 - Calbiochem Novobiocin, Sodium Salt, CAS 1476-53-5, is a DNA gyrase inhibitor that is used for the production of positively supercoiled plasma DNA. Inhibits retrovirus RNA-dependent DNA polymerases. | 1476-53-5 | 1g | $50.5 | 2022-05-15 | Buy |
Alfa Aesar | J60928 | Novobiocin sodium salt | 1476-53-5 | 1g | $47.9 | 2024-03-01 | Buy |
NOVOBIOCIN SODIUM SALT Chemical Properties,Uses,Production
Chemical Properties
crystalline
Uses
Novobiocin is an antibiotic that acts as an inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. Studies show that Novobiocin is also an inhibitor of retrovirus RNA-dependent DNA-polymerase. Novobiocin is used in the production of positively supercoiled plasmid DNA.
Novobiocin sodium salt is twice as bioavailable as the calcium salt and 50 times more available than the parent acid.
Uses
antibacterial
Uses
Topoisomerase II inhibitorNovobiocin sodium salt is effective an antistaphylococcal agent used in the treatment of Methicillin-resistant Staphylococcus aureus (MRSA). It is also used to inhibit the activity of retroviral RNA-dependent DNA polymerase as well as inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase.
brand name
Albamycin (Pharmacia & Upjohn).
Clinical Use
The action of novobiocin is largely bacteriostatic. Itsmode of action is not known with certainty, though it doesinhibit bacterial protein and nucleic acid synthesis. Studiesindicate that novobiocin and related coumarin-containingantibiotics bind to the subunit of DNA gyrase and possiblyinterfere with DNA supercoiling and energy transductionin bacteria. The effectiveness of novobiocin is confinedlargely to Gram-positive bacteria and a few strains of P. vulgaris.Its low activity against Gram-negative bacteria is apparentlybecause of poor cellular penetration.
Although cross-resistance to other antibiotics is reportednot to develop with novobiocin, resistant S. aureus strainsare known. Consequently, the medical use of novobiocin isreserved for the treatment of staphylococcal infections resistantto other antibiotics and sulfas and for patients allergicto these drugs. Another shortcoming that limits the usefulnessof novobiocin is the relatively high frequency ofadverse reactions, such as urticaria, allergic rashes, hepatotoxicity,and blood dyscrasias.
Safety Profile
Poison by intraperitoneal and subcutaneous routes. Moderately toxic by ingestion. Mutation data reported. An antibiotic with serious side effects which include liver and blood disease. It may also promote the development of resistant strains of staphylococcus. When heated to decomposition it emits toxic fumes of NOx and Na2O.
Purification Methods
The sodium salt has been recrystallised from MeOH, then dried at 60o/0.5mm. [Sensi et al, Anal Chem 29 1611 1957, Kaczka et al. J Am Chem Soc 78 4126 1956, Beilstein 18/8 IV 8125.]
NOVOBIOCIN SODIUM SALT Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21667 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
TopScience Biochemical | 00852-68527855 | info@itopbiochem.com | China Hong Kong | 902 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34571 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 8132 | 58 |
View Lastest Price from NOVOBIOCIN SODIUM SALT manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2021-07-13 | Novobiocin Sodium
1476-53-5
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | ||
2021-07-09 | Novobiocin Sodium
1476-53-5
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | ||
2019-07-06 | NOVOBIOCIN SODIUM SALT
1476-53-5
|
US $8.00 / kg | 1kg | 99% | 10MT | Career Henan Chemical Co |
- Novobiocin Sodium
1476-53-5
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
- Novobiocin Sodium
1476-53-5
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
- NOVOBIOCIN SODIUM SALT
1476-53-5
- US $8.00 / kg
- 99%
- Career Henan Chemical Co