alpha-Solanine
- CAS No.
- 20562-02-1
- Chemical Name:
- alpha-Solanine
- Synonyms
- solanine;SOLATUNIN;α-Solanin;SOLATUNINE;a-Solanine;α-Solanine;ALPHA-SOLANIN;ALPHA-SOLANINE;α-Solanine ,99%;SOLANINE, ALPHA
- CBNumber:
- CB9696314
- Molecular Formula:
- C45H73NO15
- Molecular Weight:
- 868.07
- MDL Number:
- MFCD00077873
- MOL File:
- 20562-02-1.mol
| Melting point | 285℃ (dec.) |
|---|---|
| Boiling point | 780.78°C (rough estimate) |
| Density | 1.40±0.1 g/cm3 (20 ºC 760 Torr) |
| refractive index | 1.5280 (estimate) |
| storage temp. | −20°C |
| solubility | Methanol (Slightly, Heated), Pyridine (Slightly, Sonicated), Water (Slightly, Heated) |
| form | Solid |
| pka | 6.66(at 15℃) |
| color | White to Off-White |
| Water Solubility | 26.04mg/L(15 ºC) |
| Merck | 13,8779 |
| BRN | 77607 |
| InChIKey | ZGVSETXHNHBTRK-MUEWWJAYNA-N |
| LogP | 5.670 (est) |
| FDA UNII | 15XXN7Q45T |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312+P330-P501 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 1-25-45-24/25 |
| RIDADR | 1544 |
| WGK Germany | 3 |
| RTECS | WF0250000 |
| F | 10 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 29399990 |
alpha-Solanine price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S3757 | α-Solanine from potato sprouts, ≥95% | 20562-02-1 | 5mg | $152 | 2024-03-01 | Buy |
| Sigma-Aldrich | S3757 | α-Solanine from potato sprouts, ≥95% | 20562-02-1 | 10mg | $227 | 2024-03-01 | Buy |
| Sigma-Aldrich | S3757 | α-Solanine from potato sprouts, ≥95% | 20562-02-1 | 50mg | $766 | 2024-03-01 | Buy |
| Sigma-Aldrich | PHL80074 | α-Solanine phyproof Reference Substance | 20562-02-1 | 10mg | $356 | 2024-03-01 | Buy |
| TRC | S676503 | α-Solanine | 20562-02-1 | 2.5mg | $200 | 2021-12-16 | Buy |
alpha-Solanine Chemical Properties,Uses,Production
Description
This steroidal alkaloid is present in several Solanum species including S. nigrum,
S. Iycopersicum (tomato) and S. tuberosum (potato). The base crystallizes in
slender needles and shrinks markedly at 235°C. It has [α]20D - 59.45° (pyridine)
or - 42.16° (dilute HCl) and is readily soluble in hot EtOH, sparingly so in H20
and virtually insoluble in CHCl 3 or Et2 0. The salts are mostly amorphous
although a crystalline hydrochloride has been prepared with m.p. 212°C (dec.).
It is not affected by alkalies but mineral acids hydrolyze it to solanidine (q.v.)
and one mole each of dextrose, galactose and rhamnose.
Pharmacologically, the alkaloid is a protoplasmic poison and a powerful
haemolytic. Poisoning by potatoes sometimes occurs although the results are not
usually fatal. The symptoms are nausea, headache, emesis and gastritis. With
large doses parenchymatous nephritis and haemoglobinuria occurs with, at times,
paralysis of the central nervous system and cardiac arrest. The alkaloid also
possesses local irritant properties.
Chemical Properties
White solid
Uses
α-Solanine is produced as a by product in the synthesis of α-Chaconine. α-Chaconine is a glycoalkaloid displaying nerve toxin activity. Potential antifungal activity.
Definition
ChEBI: A glycoalkaloid poison found in species of the nightshade family (Solanaceae), such as the potato (Solanum tuberosum). It is a trisccharide derivative of solanidine [(22beta)-solanid-5-en-3beta-ol].
benefits
It has been revealed that α-solanine possesses potential chemotherapeutic action against cancers in several organs, including lung, breast, esophagus, prostate, and liver, as well as acute lymphocytic leukemia. α-solanine also has potential anti-inflammatory properties[1].
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Hazard
A poison.
Side effects
A small amount of α-solanine can cause common symptoms such as dizziness, nausea, abdominal pain, vomiting, and diarrhea. Excessive consumption of α-solanine can lead to convulsions, coma, and even death. Animal studies have shown that α-solanine can damage the reproductive system[1].
Purification Methods
Recrystallise -solanine from EtOH, 85% aqueous EtOH, MeOH or aqueous MeOH as dihydrate m 276-278o. It solubility in H2O is 25mg/L and 5% in pyridine, but it is very soluble in Et2O and CHCl3. The hydrochloride is gummy or amorphous but has been crystallised (m ~212o dec). It has insecticidal properties. [Kuhn et al. Chem Ber 88 1492 1955, Beilstein 21 III/IV 1402.]
References
Desfosses.,lahresb., 2, 114 (1820)
Firbas., Monatsh., 10, 541 (1889)
Cazeneuve, Breteau., Compt. rend., 128,887 (1899)
Davis., Pharm. I., 15, 160 (1902)
Wittman., Monatsh., 26,445 (1905)
Colombano., Gazzetta, 38, 19 (1908)
Zemplen, Gerecs., Ber., 61,2294 (1928)
Schopf, Herrmann., ibid, 66, 298 (1933)
Oddo, Caronna., ibid, 67,446 (1934)
References
[1] Zhilong Chen. “α-Solanine Causes Cellular Dysfunction of Human Trophoblast Cells via Apoptosis and Autophagy.” Toxins (2021).
alpha-Solanine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9702 | 58 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 | 1057@dideu.com | China | 3487 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12527 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9271 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29118 | 58 |
| Hebei Duling International Trade Co. LTD | +8618032673083 | sales05@hbduling.cn | China | 15744 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
View Lastest Price from alpha-Solanine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-06-24 | ALPHA-SOLANINE USP/EP/BP
20562-02-1
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2020-05-10 | α-Solanine
20562-02-1
|
US $1.00 / KG | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd |
-
- ALPHA-SOLANINE USP/EP/BP
20562-02-1
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- α-Solanine
20562-02-1
- US $1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd