ジチオりん酸O,O-ジメチルS-[(4-オキソ-1,2,3-ベンゾトリアジン-3(4H)-イル)メチル] 化学特性,用途語,生産方法
用途
農薬(殺虫剤)
農薬用途
殺虫剤
化学的特性
Pure azinphos-methyl is a colorless-to-white odorless crystalline
solid. Azinphos-methyl is subject to hydrolysis and
decomposes with gas evolution at elevated temperatures.Soluble in methanol, ethanol, propylene glycol,
xylene, and other organic solvents; slightly
soluble in water (33 mg/L).
使用
Azinphos-methyl is used to control a wide range of both sucking
and chewing insects and spider mites in a wide range of crops.
定義
ChEBI: A member of the class of benzotriazines that is 1,2,3-benzotriazine substituted by an oxo group at position 4 and a [(dimethoxyphosphorothioyl)sulfanyl]methyl group at position 3.
一般的な説明
Azinphos methyl is a colorless brown, waxy or white crystalline solid dissolved in a liquid carrier. AZINPHOS-METHYL is used as a pesticide. AZINPHOS-METHYL is added to water to create a water emulsifiable liquid. AZINPHOS-METHYL is toxic by inhalation, skin absorption, and/or ingestion. AZINPHOS-METHYL is heavier than and insoluble in water.
Technical-grade guthion is a cream to yellowbrown granular solid. Guthion is poorly soluble in water. Pure guthion is a colourless to white odourless crystalline solid. Technical-grade guthion is a cream to yellow-brown granular solid.
空気と水の反応
Insoluble in water. What little amount is solubilized will readily hydrolyze.
反応プロフィール
The BPS Pesticide incident in Helena resulted in an explosion and death of three firemen. The burning of a 1,000 pound sack of Azinphos Methyl or the flashing of Maneb which was present on the facility may have caused the explosion. Azinphos Ethyl may behave similarly. At elevated temperatures, AZINPHOS-METHYL will decompose generating toxic gases.
危険性
A poison, cholinesterase inhibitor.
Absorbed by skin. Questionable carcinogen.
健康ハザード
Acute: extremely toxic. Probable oral lethal dose in humans is 5-50 mg/kg, or between 7 drops and 1 teaspoon for a 70 kg (150 lb.) person. A potent cholinesterase inhibitor which can cause death.
火災危険
Some of the formulations may burn, but none of them ignite easily. Container may explode in the heat of the fire. Rapidly hydrolyzed by cold alkali or cold acid. Unstable at temperatures above 390F.
农业用途
Insecticide, Acaricide: Not approved for use in EU countries. Azinphosmethyl
liquids with a concentration greater than 13.5%
are classified as a U.S. Restricted Use Pesticides (RUP)
Insecticide used to control certain chewing and sucking
insects in forestry settings, on fruits and fruit trees, vines,
nuts, vegetables, cereals, maize, cotton, ornamentals, soy
beans, tobacco, rice, coffee, sugar cane, and other crops.
Also used as an intermediate in the manufacture, formulation
and application of insecticides and acaricides.
There are 31 global suppliers.
製品名
ACIFON®; AZINPHOS-METHYL
GUTHION®; BAY 9027®; BAYER 17147®; CARFENE®;
COTNION-METHYL®; CRYSTHION 2 L®;
CRYSTHYON®; DBD®; GOTHNION®; GUSATHION®;
GUSATHION M®; GUTHION®; R 1582®
安全性プロファイル
Poison by inhalation,
ingestion, skin contact, intravenous, and
intraperitoneal routes. An experimental
teratogen. Other experimental reproductive
effects. Human mutation data reported.
Questionable carcinogen with experimental
tumorigenic data. See also PARATHION
and ESTERS. When heated to
decomposition it emits very toxic fumes of
POx, SOx, and NOx.
発がん性
In a 2 year study dogs received
azinphos-methyl technical (purity not stated) in the diet at 0, 5,
20, or 50 ppm . After 36 weeks, the 20 ppm and 50 ppm
dose groups were given 50 and 100 ppm, respectively, upon
lack of toxic symptoms. After 57 weeks, the 100 ppm dose
group was elevated to 150 ppmand after 84weeks to 300 ppm.
No evidence of carcinogenicity was observed.When azinphos-methyl was fed to mice at 0, 5, 20, or
40 ppm (about 0.79, 3.49, 11.33 (males); 0.98, 4.12, 14.30
(females)) for 2 years, no compound-related toxicity or
evidence of cancer occurred .
環境運命予測
Biological. Mixed cultures of microorganisms obtained from soil, raw sewage, acti vated sludge, and settled sludge were all able to degrade azinphosmethyl. When this
dithioate pesticide was incubated in a stirred flask containing a mixed culture for 4 days,
the concentration decreased from 99 to 40 mg/L (Barik et al., 1984).
Soil. The principal degradation products in soil and by selected soil microorganisms
are benzazimide, thiomethylbenzazimide, bis(benzazimidylmethyl)disulfide and anthra nilic acid. Benzazimide is further transformed only by Pseudomonas sp. DSM 50
When radiolabeled azinphos-methyl was incubated in soil, 50 and 93% of the applied
amount degraded to carbon dioxide after 44 and 197 days, respectively (Engelhardt et al.,
1984). The presence of benzamide, salicylic acid and 14CO2 from [carbonyl-14C]- an
In a dry soil (2–3% moisture content), the half-lives were 484, 88 and 32 days at 6,
25 and 40°C, respectively. In a soil containing 50% moisture, the half-lives were much
shorter, i.e., 64, 13 and 5 days at 6, 25 and 40°C, respectively (Yaron et al., 1974).
Azinphos-methyl will not leach to any great extent in soil (Helling, 1971). Staiff et
al. (1975) studied the persistence of azinphos-methyl in a test plot over an 8-year period.
At the end of the eighth year, virtually no azinphos-methyl was detected 30 c
代謝経路
In the apple tree, 14C-azinphos methyl is metabolized
to a small degree and, by the cell culture, 71% of the
applied activity consists of unchanged azinphos methyl
and its oxon is identified as a metabolite in a small
amount. Two major metabolites are identified in the
aqueous phase of the peel extract and in the cell
extracts of the cell cultures. The major one is a
conjugate of mercaptomethylbenzazimide with 2-(1-
glucopyranosyl)propionic acid, and the minor one is
monodesmethylazinphos methyl. In rats, following the
administration of a single dose of azinphos methyl, the
major radioactivity is eliminated in the expired air
within 48 h. The metabolites in the urine result from
the cleavage of P-S-C and P-O-CH3 bonds
yielding O,O-dimethyl phosphorothioic acid together
with mercaptomethylbenzamide and mono-O-
demethylated azinphos methyl, respectively.
貯蔵
Azinphos methyl only should be handled by trained occupational workers/personnel
wearing proper protective clothing. Azinphos methyl should always be stored and
transported in clearly labeled impermeable containers under lock and key. Its storage
area should be secure from access by unauthorized persons and children. Occupational workers must be properly informed that no food or drink should be stored in the storage
areas.
予防処置
Heptachlor decomposes on heating above 160°C, producing toxic fumes including hydro-
gen chloride. It reacts with strong oxidants and attacks metal. During use and handling of
liquid and powder formulations of heptachlor, occupational workers should wear protec-
tive neoprene or PVC gloves, cotton overalls, rubber boots, and a face shield or dust mask.
Heptachlor should be kept stored in locked buildings.
ジチオりん酸O,O-ジメチルS-[(4-オキソ-1,2,3-ベンゾトリアジン-3(4H)-イル)メチル] 上流と下流の製品情報
原材料
準備製品