ティプラシニン

ティプラシニン 価格 もっと(8)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
富士フイルム和光純薬株式会社(wako)	W01TOC5565	Tiplaxtinin	393105-53-8	10mg	￥48000	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01COBQJ-0146	Tiplaxtinin	393105-53-8	100mg	￥235000	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01COBQJ-0146	Tiplaxtinin	393105-53-8	1g	￥935000	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01COBQJ-0146	Tiplaxtinin	393105-53-8	250mg	￥310500	2023-06-01	購入
Sigma-Aldrich Japan	PZ0295	チプラクスチニン ≥98% (HPLC) Tiplaxtinin ≥98% (HPLC)	393105-53-8	5mg	￥23900	2024-03-01	購入

ティプラシニン 化学特性,用途語,生産方法

効能

抗肥満薬, プラスミノーゲン活性化因子阻害因子(PAI1)阻害薬

説明

Tiplaxtinin is an inhibitor of plasminogen activator inhibitor 1 (PAI-1; IC₅₀ = 2.7 μM for the human enzyme). It inhibits differentiation of human adipocytes when used at a concentration of 5 μM. Tiplaxtinin (5 and 20 mg/kg) reduces tumor growth and microvessel density in a T24 bladder cancer mouse xenograft model. It prevents carotid artery occlusion, increases the time to occlusive thrombosis, and decreases the thrombus size in a rat model of ferric chloride-induced arterial thrombosis when administered at a dose of 1 mg/kg.

使用

Tiplaxtinin inhibits smooth muscle cells (SMC) migration and intimal hyperplasia. A novel therapeutic agent to improve diabetic wound.

定義

ChEBI: Tiplasinin is a member of indole-3-acetic acids. It is a potent and selective PAI-1 inhibitor. Tiplaxtinin demonstrated efficacy in vivo in multiple models of acute arterial thrombosis and has been shown to reduce physiologic PAI-1 activity.

Biochem/physiol Actions

Tiplaxtinin has high oral bioavailability. It is metabolically stable and shows large safety multiples in animal toxicology studies. Tiplaxtinin can be easily synthesized in bulk quantities. This drug also reduces diet-induced obesity in mice.

ティプラシニン 上流と下流の製品情報

原材料

準備製品

ティプラシニン 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Baoji Guokang Bio-Technology Co., Ltd.	0917-3909592 13892490616	gksales1@gk-bio.com	China	9331	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
Alfa Chemistry	+1-5166625404	Info@alfa-chemistry.com	United States	21317	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58

393105-53-8(ティプラシニン)キーワード:

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• 393105-53-8
• 2-(1-benzyl-5-(4-(trifluoromethoxy)phenyl)-1H-indol-3-yl)-2-oxoacetic acid
• TIPLAXTININ(PAI-039)
• 1H-Indole-3-aceticacid, a-oxo-1-(phenylmethyl)-5-[4-(trifluoromethoxy)phenyl]-
• 2-[1-benzyl-5-[4-(trifluoromethoxy)phenyl]indol-3-yl]-2-oxo-acetic aci d
• tiplasinin
• Tiplaxtinin
• PAI-039
• alpha-Oxo-1-(phenylmethyl)-5-[4-(trifluoromethoxy)phenyl]-1H-indole-3-acetic acid
• PAI 039 Tiplaxtinin
• Tiplaxtinin(PAI-039), >98%
• α-Oxo-1-(phenylmethyl)-5-[4-(trifluoromethoxy)phenyl]-1H-indole-3-acetic acid
• CS-1464
• TIPLAXTININ;PAI039;PAI 039
• 1H-Indole-3-acetic acid, α-oxo-1-(phenylmethyl)-5-[4-(trifluoromethoxy)phenyl]-
• Tiplaxtinin >=98% (HPLC)
• ティプラシニン
• [1-ベンジル-5-[4-(トリフルオロメチルオキシ)フェニル]-1H-インドール-3-イル]-2-オキソ酢酸
• 2-{1-ベンジル-5-[4-(トリフルオロメトキシ)フェニル]-1H-インドール-3-イル}-2-オキソ酢酸
• α-オキソ-1-ベンジル-5-[4-(トリフルオロメトキシ)フェニル]-1H-インドール-3-酢酸