A77636塩酸塩

A77636塩酸塩 価格 もっと(4)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
富士フイルム和光純薬株式会社(wako)	W01TOC1701	A77636塩酸塩 A 77636 hydrochloride	145307-34-2	10mg	￥76000	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01TOC1701	A77636塩酸塩 A 77636 hydrochloride	145307-34-2	50mg	￥314000	2024-03-01	購入
Sigma-Aldrich Japan	A255	A-77636 塩酸塩 水和物 ≥98% (HPLC), solid A-77636 hydrochloride hydrate ≥98% (HPLC), solid	145307-34-2	10mg	￥75500	2024-03-01	購入
Sigma-Aldrich Japan	A255	A-77636 塩酸塩 水和物 ≥98% (HPLC), solid A-77636 hydrochloride hydrate ≥98% (HPLC), solid	145307-34-2	100mg	￥709300	2018-12-25	購入

A77636塩酸塩 化学特性,用途語,生産方法

説明

A-77636 is a dopamine D₁ receptor agonist (K_i = 40 nM). It induces activity equal to or greater than dopamine in an adenylate cyclase assay of D₁ receptor activity in fish retina and rat caudate putamen (EC₅₀s = 7.4 and 1.1 nM, respectively) but does not show agonist activity at D₂ receptors expressed in MMQ cells when used at concentrations up to 10 μM. A-77636 (10 μM) induces desensitization of dopamine-stimulated cAMP accumulation and downregulation of D₁ receptors, reducing D₁ receptor expression by 79% in C-6 glioma cells expressing monkey D_1A receptors. In a marmoset model of Parkinson''s disease induced by MPTP, A-77636 (3 μmol/kg, s.c.) increases locomotor activity 5.3-fold and reduces disease severity. Subcutaneous administration of A-77636 elicits cortical acetylcholine release at a dose of 1 μmol/kg. It also elicits over a 230% increase in cortical and hippocampal acetylcholine release when administered at a dose of 4 μmol/kg, an effect that is blocked by the D₁ antagonist SCH 23390 .

生物活性

Potent and selective dopamine D 1 -like receptor agonist (pEC 50 values are 8.97 and < 5 for D 1 -like and D 2 -like receptors respectively). Displays anti-Parkinsonian activity following oral administration in vivo .

A77636塩酸塩 上流と下流の製品情報

原材料

準備製品

A77636塩酸塩 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8449	60
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9414	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
Energy Chemical	021-58432009 400-005-6266	marketing1@energy-chemical.com	China	44894	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8141	58
Changzhou Furuisi Biotechnology Co., Ltd	0519-85524369	3477467573@qq.com	China	8618	58
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840 15801484223	psaitong@jm-bio.com	China	29834	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24131	58

145307-34-2(A77636塩酸塩)キーワード:

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• 145307-34-2
• (-)-(1R,3S)-3-ADAMANTYL-1-(AMINOMETHYL)-3,4-DIHYDRO-5,6-DIHYDROXY-1H-2-BENZOPYRAN HYDROCHLORIDE
• (1R-CIS)-1-(AMINOMETHYL)-3,4-DIHYDRO-3-TRICYCLO[3.3.1.13,7]DEC-1-YL-[1H]-2-BENZOPYRAN-5,6-DIOL HYDROCHLORIDE
• A 77636 HYDROCHLORIDE
• (1R)-cis-1-Aminomethyl-3,4-dihydro-3-tricyclo[3.3.1.13.7]dec-1-yl-[1-h]-2-benzopyran-5,6-diolhydrochloride
• A 77636
• (-)-(1R,3S)-3-Adamantyl-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyran hydrate hydrochloride
• A-77636 hydrate hydrochloride
• (?)-(1R,3S)-3-Adamantyl-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyran hydrochloride hydrate
• A-77636 hydrochloride hydrate
• (1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol hydrochloride
• (-)-(1R,3S)-3-ADAMANTYL-1-(AMINOMETHYL)-3,4-DIHYDRO-5,6-DIHYDROXY-1H-2-BENZOPYRAN HYDROCHLORIDE
• A77636塩酸塩
• A-77636 塩酸塩 水和物