(-)-ベンジル酸3-キヌクリジニル 化学特性,用途語,生産方法
説明
The 3-quinuclidinyl benzilate (3-QNB) was first discovered by
Hoffmann-La Roche in 1951 during research investigation
that involved development of antispasmodic agents, resembling
atropine, for treating gastrointestinal conditions. Soon
after, the US Army investigated 3-QNB under the name of
EA2277 agent and was standardized for use in chemical
munitions in 1961 under the name agent of BZ. The United
States declared complete destruction of its stockpile of BZ by
1989. Moreover, Agent 15 is speculated either to be identical
to BZ or a closely related derivative, and has similar physicochemical
properties as BZ. In 1998, Agent 15 was speculated
to be stockpiled by Iraq but later on intelligence reports did
not find any conclusive evidence for such claim1. The BZ is
a glycolate anticholinergic chemical related to atropine,
scopolamine, and, hyoscyamine. It is odorless, nonirritating,
and is stable in most solvents. It has a half-life of 3–4 weeks in
moist air and is extremely persistent in soil, water, and most
surfaces. BZ has a slow onset and a long duration-of-action.
The rate of BZ action climaxed after 9.5 h of exposure and the
duration-of-action could last up to 96 h. Moreover, most of
the causalities of BZ exposure will require physical restraint
and continuous monitoring to prevent self-injury and paranoia
symptoms during recovery
2. Recent speculation about
the usage of Agent 15 in Syrian civil war had been reported
but no confirmation findings had been established
3.
化学的特性
Colourless solid
使用
3-quinuclidinyl benzilate(BZ) is a nonlethal chemical warfare agent that following a delayed onset is incapacitating and causes severe hallucinations. US Army intended to use BZ in critical point situations such as special operation, incapacitating adversaries during raid, and overcoming fortified field positions. Medically, BZ is used as a muscarinic receptor antagonist.
一般的な説明
Colorless liquid, odorless to fruity.
環境運命予測
BZ acts by blocking the action of acetylcholine on the central
and peripheral nervous systems. It is a tertiary amine and
crosses the blood–brain barrier. BZ on acute exposure
increases both heart and respiratory rates, dilates the pupils,
and causes paralysis of the eye muscles necessary for near
focusing. It also causes dry mouth and skin, elevates body
temperature, impairs coordination, and causes flushing of the
skin, hallucinations, stupor, forgetfulness, and confusion.Within 15 min to 4 h following exposure, the principal effects
are dizziness, involuntary muscle movements, near vision
difficulty, and total incapacitation. From 6 to 10 h after
exposure, the effects are psychotropic and full recovery is expected after 4 days.
The peripheral nervous system effects are considered as
understimulation of the end organs. This decreased stimulation
of eccrine and apocrine sweat glands in the skin results in dry
skin and a dry mouth, and is considered ‘dry as a bone.’ The
reduction in the ability to dispel heat by evaporative cooling
decreases sweating, and the compensatory cutaneous vasodilation
causes the skin to become warm or ‘hot as a hare’ and ‘red
as a beet.’ This is similar to the atropine flush. The decreased
heat loss also results in an increased core temperature.
(-)-ベンジル酸3-キヌクリジニル 上流と下流の製品情報
原材料
準備製品