(1R,2S)-(-)-ノルエフェドリン 化学特性,用途語,生産方法
外観
白色～わずかにうすい黄色, 結晶～結晶性粉末
溶解性
水、エタノール及びアセトンに溶ける。
説明
This alkaloid was first isolated by Kanao from the Chinese drug 'Ma-Huang'
(Ephedra sinica Stapf.) and later by Wolfes from E. helvetica C. A. Meyer and E.
distachya Linn. It forms a crystalline mass and has [α]
20
D - 14.56° (EtOH).
Several crystalline salts and derivatives are known: the hydrochloride has m.p.
171-2°C; [α]
20
D- 33.27° (H20); the sulphate dihydrate, m.p. 285-6°C (dry,
dec.); [α]
28
D- 31.99° (H20); the aurichloride, m.p. 188°C; platinichloride, m.p.
221°C (dec.); (-)-hydrogen tartrate, m.p. about 160° after sintering at 130°C;
oxalate, m.p. 245°C (dec.) and the p-nitrobenzoyl derivative, m.p. 175-6°C;
[α]
28
D- 49.58° (CHCI3).
The (+)-form has m.p. 52°C; [α]
27
D + 14.76° (EtOH), yielding a hydro_x0002_chloride, m.p. 171-2°C; [α]
27
D + 33.4° (EtOH); sulphate dihydrate, m.p. 285-
6°C (dry, dec.); [α]
27
D+ 31.51 0 C (H20); aurichloride, m.p. 188°C (dec.) and
platinichloride, m.p. 221.5°C (dec.). The (±)-form crystallizes as colourless
plates from Et20, m.p. 104-5°C and also furnishes a series of crystalline salts
and derivatives.
化学的特性
white powder
使用
A metabolite of Phenmetrazine.
安全性プロファイル
A human poison by
ingestion. Poison experimentally by
intravenous, subcutaneous, and
intraperitoneal routes. Moderately toxic by
an unspecified route. Human systemic
effects by ingestion: sleep, increased pulse
rate without blood pressure decrease, and
chronic pulmonary edema or congestion,
convulsions, headache, and blood pressure
elevation. Used in production of drugs of
abuse. When heated to decomposition it
emits toxic fumes of NOx.
参考文献
Kanao., Ber., 63,95 (1930)
Wolfes., Arch. Pharrn., 268,87 (1930)
Hey., J. Chern. Soc., 1232 (1930)
Akabori, Momotani., J. Chern. Soc., Japan, 64, 608 (1943)
Hoover, Hass., J. Org. Chern., 12,506 (1947)
(1R,2S)-(-)-ノルエフェドリン 上流と下流の製品情報
原材料
準備製品