D-(+)-ラフィノース五水和物 化学特性,用途語,生産方法
外観
白色, 結晶〜粉末
溶解性
水に溶けやすく、エタノールに溶けにくい。
用途
糖研究用、ビフィズス菌増殖剤。
説明
D-
(+)-
Raffinose is a trisaccharide composed of galactose, glucose, and fructose that occurs naturally in a variety of vegetables and grains. It is hydrolyzed to galactose and sucrose by α-
galactosidase.
使用
D-(+)-Raffinose is a trisaccharide built from 1 mol each of D-galactose, D-glucose, and D-fructose which are obtained from it by acid hydrolysis. Invertase splits it into melibiose and saccharose.
D-
(+)-Raffinose occurs in Australian manna; in cottonseed meal.
調製方法
Raffinose occurs naturally in Australian manna, cottonseed meal,
and seeds of various food legumes. It can be isolated from beet sugar
molasses through sucrose separation, seed-crystallization, and
filtration.
応用例（製薬）
Raffinose is a trisaccharide carbohydrate that is used as a bulking
agent, blood substitute, stabilizing agent, and water scavenger in
freeze-drying where it acts as a stabilizer for freeze-dried formulations. It is also used as a crystallization inhibitor in sucrose
solutions.
安全性
Raffinose is a naturally occurring trisaccharide investigated for use
in freeze-dried pharmaceutical formulations. It occurs in a number
of plants that are consumed widely.
貯蔵
Raffinose is stable under ordinary conditions of use and storage.
Excessive heat should be avoided to prevent degradation. Thermal decomposition products are carbon monoxide and carbon dioxide.
純化方法
fructo-furanose [17629-30-0 (5H2O), 512-69-6 (anhydrous)] M 594.5, m 8 0o, 80 -82o, +124o (c 10, H2O), [ ] D +105o (c 1 for pentahydrate, H2O), pK 1 12.40, pK 2 13.44, pK 3 13.52. D(+)-Raffinose crystallises from H2O, 90% aqueous EtOH or MeOH as the pentahydrate. The anhydrous sugar has m 132-135o. It has RF 0.8 on TLC (Silica Gel, and 1:3:3 CHCl3/butanone:/MeOH). The undecaacetate has been purified through an alumina column by elution with CHCl3, and recrystallised from EtOH/MeOH/H2O (3:2:5), with m 99-100o, [] D +92.8o (c 5.14, EtOH). [pK : Coccioli & Vicedomini Ann Chim (Rome) 66 269, 275 1976, 1H NMR: Suami et al. Carbohydr Research 26 234 1973, Beilstein 17 III/IV 3801, 17/8 V 403.]
不和合性
Raffinose is incompatible with strong oxidizers.
規制状況(Regulatory Status)
Raffinose is a naturally occurring trisaccharide and is consumed as
part of a normal diet.
D-(+)-ラフィノース五水和物 上流と下流の製品情報
原材料
準備製品