MF-63

MF-63 価格

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入

MF-63 化学特性,用途語,生産方法

説明

Microsomal prostaglandin E₂ synthase-1 (mPGES-1) is the terminal enzyme in the biosynthesis of PGE₂. MF63 is a potent, selective, and orally active inhibitor of human mPGES-1 (IC₅₀ = 1.3 nM). It displays greater than 1,000-fold selectivity over other prostanoid synthases. MF63 also potently inhibits guinea pig mPGES-1 (IC₅₀ = 0.9 nM) but not mouse or rat mPGES-1. In guinea pigs or in mice expressing human mPGES-1, MF63 prevents LPS-induced pyresis, hyperalgesia, and iodoacetate-induced osteoarthritic pain. It does not produce the gastrointestinal toxicity that is caused by non-selective COX inhibitors, although it markedly suppresses PGE₂ synthesis in the stomach.

使用

MF 63 is a microsomal prostaglandin E2 synthase-1 (mPGES-1) the final enzyme in the synthesis of PGE2. Prevents LPS-induced hyperglasia. Anti-inflammatory, analgesic, anti-cancer agent.

MF-63 上流と下流の製品情報

原材料

準備製品

MF-63 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33349	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	6011	61
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7553	61

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• 892549-43-8
• MF-63
• 2-(9-Chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-1,3-benzenedicarbonitrile
• 2-(6-chloro-1H-phenanthro-[9,10-d]iMidazol-2-yl)isophthalonitrile
• 2-(9-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-1,3-Benzenedic
• MF 63; MF-63
• CS-2773
• 1,3-Benzenedicarbonitrile, 2-(9-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-
• 2-(9-Chloro-1H-phenanthro[9, 10-d]imidazol-2-yl)benzene-1, 3-dicarbonitrile