MF-63

892549-43-8

CAS-Nr.: 892549-43-8

Englisch Name:: MF-63

Synonyma:: MF-63;CS-2773;MF 63; MF-63;2-(9-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-1,3-Benzenedic;2-(6-chloro-1H-phenanthro-[9,10-d]iMidazol-2-yl)isophthalonitrile;2-(9-Chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-1,3-benzenedicarbonitrile;2-(9-Chloro-1H-phenanthro[9, 10-d]imidazol-2-yl)benzene-1, 3-dicarbonitrile;1,3-Benzenedicarbonitrile, 2-(9-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-

CBNumber:: CB22512521

Summenformel:: C23H11ClN4

Molgewicht:: 378.81

MOL-Datei:: 892549-43-8.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 82

MF-63 Eigenschaften

Siedepunkt:: 709.7±70.0 °C(Predicted)

Dichte: 1.49

storage temp.: Store at -20°C

Löslichkeit: Soluble in DMSO

Aggregatzustand: crystalline solid

pka: 11.34±0.30(Predicted)

Sicherheit

MF-63 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Microsomal prostaglandin E₂ synthase-1 (mPGES-1) is the terminal enzyme in the biosynthesis of PGE₂. MF63 is a potent, selective, and orally active inhibitor of human mPGES-1 (IC₅₀ = 1.3 nM). It displays greater than 1,000-fold selectivity over other prostanoid synthases. MF63 also potently inhibits guinea pig mPGES-1 (IC₅₀ = 0.9 nM) but not mouse or rat mPGES-1. In guinea pigs or in mice expressing human mPGES-1, MF63 prevents LPS-induced pyresis, hyperalgesia, and iodoacetate-induced osteoarthritic pain. It does not produce the gastrointestinal toxicity that is caused by non-selective COX inhibitors, although it markedly suppresses PGE₂ synthesis in the stomach.

Verwenden

MF 63 is a microsomal prostaglandin E2 synthase-1 (mPGES-1) the final enzyme in the synthesis of PGE2. Prevents LPS-induced hyperglasia. Anti-inflammatory, analgesic, anti-cancer agent.

MF-63 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

MF-63 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 82)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49391	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33349	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	6011	61
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7553	61

MF-63
2-(9-Chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-1,3-benzenedicarbonitrile
2-(6-chloro-1H-phenanthro-[9,10-d]iMidazol-2-yl)isophthalonitrile
2-(9-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-1,3-Benzenedic
MF 63; MF-63
CS-2773
1,3-Benzenedicarbonitrile, 2-(9-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-
2-(9-Chloro-1H-phenanthro[9, 10-d]imidazol-2-yl)benzene-1, 3-dicarbonitrile
892549-43-8
C23H11ClN4