ピンドロール 化学特性,用途語,生産方法
外観
白色~わずかにうすい紅色, 結晶性粉末~粉末
溶解性
氷酢酸に易溶、メタノールに微溶、無水エタノール,アセトンに難溶。希硫酸,氷酢酸に可溶、メタノールにやや可溶、無水エタノール,アセトンに難溶、水,エーテルにほとんど不溶。
用途
薬理研究用。
用途
Βアドレナリン遮断剤、高血圧、不整脈の治療
用途
β1 選択的遮断剤です。
効能
抗不整脈薬, 血圧降下薬, 血管拡張薬, β遮断薬
商品名
カルビスケン (アルフレッサファーマ)
化学的特性
White Solid
使用
Pindolol, like nadolol, is a nonselective β-adrenoblocker. It possesses antianginal, antihypotensive, and antiarrythmic action. It is used for arterial hypertension, angina stress (preventing attacks), supraventricular tachycardia, tachsystolic form of atrial fibrillation, and
superventricular extrasystole.
定義
ChEBI: A member of the class of indols which is the 2-hydroxy-3-(isopropylamino)propyl ether derivative of 1H-indol-4-ol.
生物活性
5-HT 1A/1B ? receptor antagonist, with roughly equal affinity for each subtype. A partial agonist at mouse and human β 3 -adrenoceptors.
代謝経路
Several metabolites of pindolol formed in vitro are
detected after a 24 h incubation of human hepatocytes
in both pure culture and co-culture by adding rat liver
epithelial cells. The hepatocytes are able to oxidize
the isopropyl amine moiety and the pyrrole ring of the
indole moiety and conjugate pindolol as sulfates and
glucuronides.
代謝
Pindolol (Visken) is extensively absorbed from the
gastrointestinal tract. First-pass metabolism is estimated
at about 15%, and its plasma half-life is on the order of
3 to 4 hours.The binding of pindolol to plasma proteins
is approximately 50%.The metabolic fate of pindolol is
not completely understood, although 50% of an administered
dose is recovered, primarily in the urine, as unchanged
drug.
ピンドロール 上流と下流の製品情報
原材料
準備製品