タルチレリン

タルチレリン 価格 もっと(8)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
富士フイルム和光純薬株式会社(wako)	W01MAS076043	タルチレリン acetate Taltirelin acetate	103300-74-9	250mg	￥204700	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01MAS076043	タルチレリン acetate Taltirelin acetate	103300-74-9	1g	￥440700	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01TRCT005650	Taltirelin Trifluoroacetic Acid Salt	103300-74-9	10mg	￥57900	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01TRCT005650	Taltirelin Trifluoroacetic Acid Salt	103300-74-9	100mg	￥459900	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01TOC2672	Taltirelin	103300-74-9	1mg	￥27000	2021-03-23	購入

タルチレリン 化学特性,用途語,生産方法

外観

白色～ほとんど白色, 結晶性粉末～粉末

用途

中枢神経系に存在するTRH（甲 状腺刺激ホルモン放出ホルモン）受容体に結 合し、アセチルコリン、ドーパミン、ノルア ドレナリン、セロトニン神経系を活性化し、 運動失調症状の改善作用を示します。

使用上の注意

不活性ガス封入

説明

Taltirelin was marketed in Japan for the treatment of neurodegenerative diseases, in particular the improvement of ataxia due to spino-cerebellar degeneration (SCD); it is the first orally-active drug in this indication. This synthetic thyrotropin-releasing hormone (TRH) analog is prepared by condensation of (S)-1-methyl-4,5-dihydroorotic acid with L-histidyl-Lprolinamide. It was shown that the S-configuration for all 3 chiral centers is crucial for CNS activity. Taltirelin is a potent agonist of the TRH receptors that shows significant effects on the cerebral monoamine systems when administered i.p. in rats. As TRH at 10-fold higher doses, taltirelin has been found to increase the extracellular levels of dopamine and its metabolites (DOPAC and HVA) as well as precursors and/or metabolites of noradrenaline and serotonin in different areas of the rat brain. Taltirelin produced an anti-ataxic activity in the Rolling mouse Nagoya, an ataxic mutant mouse. In several clinical studies performed in patients suffering from various forms of SCD, taltirelin demonstrated a statistically significant increase in the global improvement of ataxic symptoms and other neurologic abnormalities.

使用

Taltirelin is a thyrotropin-releasing hormone analog.

生物活性

Synthetic thyrotropin-releasing hormone (TRH) analog. Displays ~ 30-100-fold more potent CNS activity and ~ 50-fold weaker endocrine activity than TRH. Antinociceptive and neuroprotective.

タルチレリン 上流と下流の製品情報

原材料

準備製品

タルチレリン 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Sigma Audley	+86-18336680971 +86-18126314766	nova@sh-teruiop.com	China	525	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10248	58
Shaanxi Pioneer Biotech Co., Ltd .	+8613259417953	sales@pioneerbiotech.com	China	3000	58
Beijing Yibai Biotechnology Co., Ltd	0086-182-6772-3597	sales04@yibaibiotech.com	CHINA	419	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10297	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17367	58

103300-74-9(タルチレリン)キーワード:

---

• 103300-74-9
• Taltirelin interMediate
• (4S)-Hexahydro-1-Methyl-2,6-dioxo-4-pyriMidinecarbonyl-L-histidyl-
• Ceredist, TA-0910
• TALTIRELIN INTERMEDIATES
• Taltirelin Acetate,TA-0910
• Taltirelin
• L-Prolinamide, N-[(hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl)carbonyl]-L-histidyl-, (S)-
• L-Prolinamide, N-[[(4S)-hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl]carbonyl]-L-histidyl- (9CI)
• TA 0910
• (4S)-N-[(2S)-1-[(2S)-2-Carbamoylpyrrolidin-1-yl]-3-(3H-imidazol-4-yl)-1-oxopropan-2-yl]-1-methyl-2,6-dioxo-1,3-diazinane-4-carboxamide
• 2,6-dioxo-4-pyrimidinecarbonyl-L-histidyl-
• L-Prolinamide,(4S)-hexahydro-1-methyl-
• (6S)-N-[(S)-1-[[(2S)-2-Carbamoylpyrrolizino]carbonyl]-2-(1H-imidazole-4-yl)ethyl]-2,4-dioxo-3-methylhexahydropyrimidine-6-carboxamide
• 1-[Nα-[[(4S)-1-Methyl-2,6-dioxohexahydropyrimidine-4-yl]carbonyl]-L-histidyl]-L-prolinamide
• N-[[[(4S)-1-Methyl-2,6-dioxohexahydropyrimidin]-4α-yl]carbonyl]-L-His-L-Pro-NH2
• Taltireline
• Taltirelin Acetate
• 1-METHYL-4,5-DIHYDROOROTYL-HIS-PRO-NH2
• TA-0910, taltirelin
• N-[[(4S)-Hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl]carbonyl]-L-histidyl-L-prolinamide
• L-Prolinamide, (4S)-hexahydro-1-methyl-2,6-dioxo-4-pyrimidinecarbonyl-L-histidyl-
• Taltirelin USP/EP/BP
• Taltirelin (TA0910)
• Taltirelin acetate salt
• Mitragynine Impurity 2
• タルチレリン
• 1-[Nα-[[(4S)-1-メチル-2,6-ジオキソヘキサヒドロピリミジン-4-イル]カルボニル]-L-ヒスチジル]-L-プロリンアミド
• N-[[[(4S)-1-メチル-2,6-ジオキソヘキサヒドロピリミジン]-4α-イル]カルボニル]-L-His-L-Pro-NH2
• N-[[[(4S)-ヘキサヒドロ-1-メチル-2,6-ジオキソピリミジン]-4α-イル]カルボニル]-L-His-L-Pro-NH2
• (6S)-N-[(S)-1-[[(2S)-2-カルバモイルピロリジノ]カルボニル]-2-(1H-イミダゾール-4-イル)エチル]-2,4-ジオキソ-3-メチルヘキサヒドロピリミジン-6-カルボアミド
• タルチレリン ACETATE
• TA-0910
• (4S)-N-[(2S)-1-[(2S)-2-カルバモイルピロリジン-1-イル]-3-(1H-イミダゾール-4-イル)-1-オキソプロパン-2-イル]-1-メチル-2,6-ジオキソ-1,3-ジアジナン-4-カルボキサミド
• 中枢神経系作用薬