アクラルビシン

アクラルビシン 価格

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入

アクラルビシン 化学特性,用途語,生産方法

効能

抗悪性腫瘍薬, トポイソメラーゼ阻害薬

説明

Aclarubicin was found in the culture broth of Streptomyces galilaeus MA144-M1 by Umezawa et al. of the Institute of Microbial Chemistry in 1975. It was produced along with structurally related compounds showing antileukemic activity and named aclacinomycin A. Sanraku-Ocean cooperated in isolating aclacinomycin A as a yellow crystalline powder and evaluated its strong antileukemic activity and low cardiac toxicity. Its generic name was changed to aclarubicin on the recommendation of the World Health Organization.

使用

Antineoplastic.

定義

ChEBI: An anthracycline antibiotic that is produced by Streptomyces galilaeus and also has potent antineoplastic activity.

安全性プロファイル

Poison by ingestion,intraperitoneal, subcutaneous, and intravenous routes. Anexperimental teratogen. Other experimental reproductiveeffects. Mutation data reported. An eye and subcutaneousirritant. When heated to decomposition it emits toxicfumes of

酵素阻害剤

This non-peptidic aclacinomycin antibiotic (FW = 811.88 g/mol; CAS CAS 57576-44-0; Source: strain of Streptomyces galilaeus), also known as aclarubicin, induces DNA strand scission. Target(s): nitric oxide synthase; RNA biosynthesis; DNA polymerase I; RNA polymerase, Escherichia coli; reverse transcriptase, avian myeloblastosis virus; Na+/K+-exchanging ATPase; Ca2+-transporting ATPase; cyclicnucleotide phosphodiesterase; electron transport and oxidative phosphorylation, mitochondrial; DNA helicase; DNA topoisomerase II; 20S proteasome, chymotrypsin-like activity; DNA topoisomerase I; 3'-5' DNA helicase, Plasmodium falciparum.

アクラルビシン 上流と下流の製品情報

原材料

準備製品

アクラルビシン 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 15319487004	1015@dideu.com	China	2263	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29016	58
BOC Sciences	+16314854226	inquiry@bocsci.com	United States	19743	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	CHINA	52867	58
ZHEJIANG JIUZHOU CHEM CO., LTD	+86-0576225566889 +86-13454675544	admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com	China	20000	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	50000	58

57576-44-0(アクラルビシン)キーワード:

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• 57576-44-0
• 1-naphthacenecarboxylicacid,2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6
• aclacur
• aclarubicinfreebase
• antibiotic3082a
• ACLARUBLCIN
• ACLARUNBICIN
• 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-α-L-lyxo-hexopyranosyl]-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy]-, methyl ester, [1R-(1α,2β,4β)]-
• Jaclacin
• Methyl (1R,2R,4S)-4-[(2R,5S,6S)-4-dimethylamino-5-[(2S,4S,5S,6S)-4-hydroxy-6-methyl-5-[(2R,6S)-6-methyl-5-oxooxan-2-yl]oxyoxan-2-yl]oxy-6-methyloxan-2-yl]oxy-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-3,4-dihydro-1H-tetracene-1-carboxylate
• Aclacin
• Aclaplastin
• Aelacinon
• MA 144A1：NSC-208734
• Aclacinomycin(Aclarubicin)
• Methyl (1R,2R,4S)-4-[4-dimethylamino-5-[4-hydroxy-6-methyl-5-(6-methyl-5-oxo-oxan-2-yl)oxy-oxan-2-yl]oxy-6-methyl-oxan-2-yl]oxy-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-3,4-dihydro-1H-tetracene-1-carboxylate
• antibiotic77-3082a
• antibioticma144a
• antibioticma144a1
• hyl-5-oxo-2h-pyran-2-yl)-alpha-l-lyxo-hexopyranosyl)-3-(dimethylamino)-alpha-
• ma144-a1
• methylester,(1r-(1-alpha,2-beta,4-beta))-l-lyxo-hexopyranosyl)oxy)
• nsc-208734
• ACM
• ACLARUBICIN
• ACLACINOMYCIN A
• ACLACINOMYCIN A, STREPTOMYCES GALILAEUS
• ,11-dioxo-4-((2,3,6-trideoxy-4-o-(2,6-dideoxy-4-o-((2r-trans)-tetrahydro-6-met
• 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R,6S)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-α-L-lyxo-hexopyranosyl]-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy]-, methyl ester, (1R,2R,4S)-
• Aclarubicin A
• Aclarubicin USP/EP/BP
• (1R)-2-エチル-1,2,3,4,6,11-ヘキサヒドロ-2α,5,7-トリヒドロキシ-6,11-ジオキソ-4α-[[2,3,6-トリデオキシ-4-O-[2,6-ジデオキシ-4-O-[[(2R)-テトラヒドロ-6α-メチル-5-オキソ-2H-ピラン]-2β-イル]-α-L-lyxo-ヘキソピラノシル]-3-(ジメチルアミノ)-α-L-lyxo-ヘキソピラノシル]オキシ]-1-ナフタセンカルボン酸メチル
• (1R)-2β-エチル-1,2,3,4,6,11-ヘキサヒドロ-4α-[[4-O-[4-O-[[(2R)-テトラヒドロ-6α-メチル-5-オキソ-2H-ピラン]-2β-イル]-2,6-ジデオキシ-α-L-lyxo-ヘキソピラノシル]-3-(ジメチルアミノ)-2,3,6-トリデオキシ-α-L-lyxo-ヘキソピラノシル]オキシ]-2,5,7-トリヒドロキシ-6,11-ジオキソ-1β-ナフタセンカルボン酸メチル
• (1R)-2-エチル-1,2,3,4,6,11-ヘキサヒドロ-2α,5,7-トリヒドロキシ-6,11-ジオキソ-4α-[[4-O-[4-O-[(2R)-(テトラヒドロ-6α-メチル-5-オキソ-2H-ピラン)-2β-イル]-2,6-ジデオキシ-α-L-lyxo-ヘキソピラノシル]-3-(ジメチルアミノ)-2,3,6-トリデオキシ-α-L-lyxo-ヘキソピラノシル]オキシ]-1β-ナフタセンカルボン酸メチル
• (1R,2R,4S)-2-エチル-1,2,3,4,6,11-ヘキサヒドロ-2,5,7-トリヒドロキシ-6,11-ジオキソ-4-[[4-O-[4-O-[(2R,6S)-テトラヒドロ-6-メチル-5-オキソ-2H-ピラン-2-イル]-2,6-ジデオキシ-α-L-lyxo-ヘキソピラノシル]-3-(ジメチルアミノ)-2,3,6-トリデオキシ-α-L-lyxo-ヘキソピラノシル]オキシ]-1-ナフタセンカルボン酸メチル
• アクラシノマイシンA
• メチル (1R,2R,4S)-4-{[(2R,4S,5S,6S)-4-(ジメチルアミノ)-5-{[(2S,4S,5S,6S)-4-ヒドロキシ-6-メチル-5-{[(2R,6S)-6-メチル-5-オキソオキサン-2-イル]オキシ}オキサン-2-イル]オキシ}-6-メチルオキサン-2-イル]オキシ}-2-エチル-2,5,7-トリヒドロキシ-6,11-ジオキソ-1,2,3,4,6,11-ヘキサヒドロテトラセン-1-カルボキシラート
• ACR【アクラルビシン】