2-メチル-8-(フェニルメトキシ)イミダゾ[1,2-a]ピリジン-3-アセトニトリル 化学特性,用途語,生産方法
説明
SCH 28080 is a reversible K
+-competitive inhibitor of H
+/K
+-ATPases that is best known for its ability to block acid secretion through its action against the gastric H
+/K
+-ATPase (IC
50 = 1.3 μM). It is effective against gastric H
+/K
+-ATPases from a variety of species and can inhibit colonic H
+/K
+-ATPases, but this activity appears to be species-dependent. SCH 28080 is also used to investigate the role of H
+/K
+-ATPases in non-mammalian organisms and to distinguish the actions of H
+/K
+-ATPases from other ATP-dependent transporters.
使用
SCH 28080 is a potent inhibitor of H+,K+-ATPase.
生物活性
Potent inhibitor of H + ,K + -ATPase (IC 50 = 20 nM); binds to the K + recognition site and is competitive with respect to K + . Inhibits gastric acid secretion in vitro and in vivo .
2-メチル-8-(フェニルメトキシ)イミダゾ[1,2-a]ピリジン-3-アセトニトリル 上流と下流の製品情報
原材料
準備製品