くえん酸カリウム·水和物 化学特性,用途語,生産方法
外観
白色, 結晶〜結晶性粉末
溶解性
水に易溶 (167g/100ml, 15℃)。エタノールに難溶。
用途
医薬品原料
用途
重金属分析における補助キレート剤、緩衝剤。
用途
緩衝剤、pH調整剤、調製液原料。
効能
アルカリ化薬
化学的特性
White/clear crystalline powder
使用
Tripotassium Citrate Monohydrate is used in manufacturing method of printed circuit board for autonomous vehicle to perform recognition, judgment, determination and execution.Citric acid is a weak organic acid that is known as a commodity chemical, as more than a million tonnes are produced every year by mycological fermentation on an industrial scale using crude sugar solutions, such as molasses and strains of Aspergillus niger. Citric acid is widely distributed in plants and in animal tissues and fluids and exist in greater than grace amounts in variety of fruits and vegetables, most notably in citrus fruits such as lemon and limes. Citric acid is mainly used as an acidifier, flavoring agent and chelating agent. Citric acid is also a metabolite of Dimethyl Fumarate (D464965), a compound
定義
ChEBI: A hydrate that is the monohydrate form of potassium citrate.
調製方法
Potassium citrate is prepared by adding either potassium bicarbonate or potassium carbonate to a solution of citric acid until effervescence ceases. The resulting solution is then filtered and evaporated to dryness to obtain potassium citrate.
一般的な説明
Potassium citrate tribasic monohydrate (KCTM) is a potassium salt that has been reported to be efficient in forming aqueous two-phase system (ATPS) with UCON 50-HB-5100, a random copolymer. This product is a high quality pharmacopoeia product that meets the testing specifications of USP (United States Pharmacopoeia). It can be employed in research and pilot studies.
応用例（製薬）
Potassium citrate is used in beverages, foods, and oral pharmaceutical
formulations as a buffering and alkalizing agent. It is also used
as a sequestering agent and as a therapeutic agent to alkalinize the
urine and to relieve the painful irritation caused by cystitis.
副作用
The most common side effects of potassium citrate are gastrointestinal. Potassium citrate can be irritating to the stomach. Potassium citrate may cause an upset stomach, nausea or vomiting, and diarrhea or loose stools.
安全性
Potassium citrate is used in oral pharmaceutical formulations and is
generally regarded as a nontoxic and nonirritant material by this
route of administration.
Most potassium citrate safety data relate to its use as a
therapeutic agent, for which up to 10 g may be administered daily,
in divided doses, as a treatment for cystitis. Although there are
adverse effects associated with excessive ingestion of potassium
salts, the quantities of potassium citrate used as a pharmaceutical
excipient are insignificant in comparison to those used therapeutically.
(IV, dog): 0.17 g/kg
貯蔵
Potassium citrate is a stable, though hygroscopic material, and
should be stored in an airtight container in a cool, dry place. It is
deliquescent in moist air.
純化方法
It solubility in H2O is 154% and it loses H2O at 180o. [Beilstein 3 III 1091.]
不和合性
Aqueous potassium citrate solutions are slightly alkaline and will
react with acidic substances. Potassium citrate may also precipitate
alkaloidal salts from their aqueous or alcoholic solutions. Calcium
and strontium salts will cause precipitation of the corresponding
citrates. Potassium citrate is incompatible with strong oxidizing
agents.
規制状況(Regulatory Status)
GRAS listed. Accepted as a food additive in Europe. Included in the
FDA Inactive Ingredients Database (oral solutions and suspensions;
topical emulsions and aerosol foams). Included in nonparenteral
medicines (cutaneous foams and emulsions; oral liquids, granules,
mixtures and soluble tablets; topical liquids, emulsions and
mousses) licensed in the UK. Included in the Canadian List of
Acceptable Non-medicinal Ingredients.
くえん酸カリウム·水和物 上流と下流の製品情報
原材料
準備製品