トリクロロアセチル クロリド 化学特性,用途語,生産方法
外観
無色～うすい黄色, 澄明の液体
溶解性
水及びエタノールと激しく分解する。
使用上の注意
加熱すると分解するアルゴン封入
化学的特性
Trichloroacetyl chloride is similar to dichloroacetyl chloride. It is a clear colourless liquid. Decomposes in water; soluble in alcohol.The acid chloride can be hydrolyzed at 75 – 85°C with water to form the free acid and hydrolyzed with ammonium hydroxide or concentrated sodium carbonate solution to form the salts.
使用
Trichloroacetyl chloride can be used for the manufacture of the esters and the anhydrides of trichloroacetic acid.It was used in the preparation of dihydro-1H-benzindoles. It was also used in the synthesis of 3-alkylbenzoxazolones.
製造方法
The acetyl chloride is prepared from trichloroacetic acid and various inorganic acid chlorides (e.g., SOCl2, PCl3) or with P2O5 and HCl. More useful methods are the oxidation of tetrachloroethylene with fuming sulfuric acid, oxygen, or fuming nitric acid and sulfuric acid at 18-20°C, or from the reaction of pentachloroethane and dry oxygen under UV light. It has been obtained in 37 % yield from carbon tetrachloride and carbon monoxide in the presence of aluminum chloride at 200°C and high pressure.The most common production method is the gas-phase, photochemical oxidation of tetrachloroethylene with oxygen. The reaction is initiated with UV light, with radioactive irradiation, or it is sensitized with chlorine or iodine.
一般的な説明
A colorless volatile liquid with a strong odor. Denser than water. Contact severely irritates skin, eyes and mucous membranes. May be very toxic by ingestion and inhalation. May be combustible.
反応プロフィール
Trichloroacetyl chloride is incompatible with water, with strong oxidizing agents, alcohols, bases (including amines). May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
健康ハザード
Highly toxic by ingestion and inhalation; strong irritant to skin and tissues.
火災危険
Material may burn but does not ignite readily. Poisonous if inhaled or swallowed; skin contact poisonous. Contact may cause burns to skin and eyes.
職業ばく露
Used in chemical syntheses.
輸送方法
UN2442 Trichloroacetyl chloride, Hazard class: 8; Labels: 8-Corrosive material, 6.1-Poisonous materials.
不和合性
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, ethers and metal salts. Violent reaction with water, forming hydrochloric acid and trichloroacetic acid.
廃棄物の処理
Do not discharge into drains or sewers. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Controlled incineration (oxides of nitrogen are removed from the effluent gas by scrubbers and/or thermal devices) Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.
トリクロロアセチル クロリド 上流と下流の製品情報
原材料
準備製品
テブフェノジド
4-ブロモピロール-2-カルボン酸メチル
イソシアン酸トリクロロアセチル
3,5,6-トリクロロピリジン-2-オール酸ナトリウム
Chlorpyrifos,E.C.
クロルピリホス
5-メチル-1H-ピロール-2-カルボン酸エチル
2,4,6-トリメチル安息香酸
2,2,2-トリクロロエタノール
3,3-ジエトキシプロピオン酸エチル
4-フルオロ-2-メチル安息香酸
4,4,4-トリクロロアセト酢酸エチル
イソシアン酸トリクロロメチル
7,7-ジクロロビシクロ[3.2.0]ヘプタ-2-エン-6-オン
α-オキソ-2-フラン酢酸
ジクロロ亜ホスフィン酸フェニル
トリクロロ酢酸メチル