メチキセン
メチキセン 価格
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メチキセン 化学特性,用途語,生産方法
効能
パーキンソン病治療薬, ムスカリン受容体拮抗薬
Originator
Tremarit Wander W. Germany,Wander ,W. Germany,1960
Manufacturing Process
To 4.9 g of finely pulverized sodium in 50 ml of absolute benzene add dropwise with stirring 12 g of chlorobenzene in 50 ml of absolute benzene. As soon as the exothermic reaction begins, maintain the temperature by cooling between 30° and 35°C, and continue stirring for 2 to 3 hours. To the resulting phenyl sodium add dropwise 19.8 g of thioxanthene in 120 ml of absolute benzene. The slightly exothermic reaction ceases after about 1 to 1? hours.
To this newly formed 9-thioxanthyl sodium add dropwise, with stirring and cooling, 13.1 g of N-methyl-3-chloromethyl-piperidine in 30 to 40 ml of absolute benzene, then continue stirring at about 25°C for 1? hours, and heat subsequently to 40°C for 1 hour. Decompose the resulting mixture by adding carefully a small amount of water, and then extract the newly formed base from the benzene solution by means of dilute hydrochloric acid. The aqueous hydrochloric solution is made alkaline by adding dilute sodium hydroxide, and the thioxanthene base is isolated by extraction with ether. This results in 22 g of a slightly yellow, viscous base of BP 171° to 175°C/0.07 mm.
The base is acidified with alcoholic hydrochloric acid. Alcohol-ether (1:2) is then added and the hydrochloride salt is crystallized as colorless flakes melting at 211° to 213°C.
Therapeutic Function
Spasmolytic
メチキセン 上流と下流の製品情報
原材料
準備製品
メチキセン 生産企業
Global( 14)Suppliers
4969-02-2(メチキセン)キーワード:
- 4969-02-2
- Methixene
- 1-Methyl-3-(9H-thioxanthen-9-ylmethyl)piperidine
- 1-Methyl-3-[(thioxanthen-9-yl)methyl]piperidine
- 60 SJ 1977
- 9H-Thioxanthene, piperidine deriv.
- Piperidine, 1-methyl-3-(9H-thioxanthen-9-ylmethyl)- (9CI)
- Piperidine, 1-methyl-3-(thioxanthen-9-ylmethyl)- (6CI, 7CI, 8CI)
- Tremaril
- Tremonil
- Trest
- 9-[(1-Methyl-3-piperidinyl)methyl]-9H-thioxanthene
- 115511-20-1 (3S)
- 115511-21-2 (3R)
- 1553-34-0 (Hydrochloride)
- 1-Methyl-3-(thioxanthen-9-ylmethyl)-1-piperidine
- 1-Pipecoline, 3-(thioxanthen-9-yl)methyl-
- 60 Sj 1977 (*hydrochloride*)
- 9-(1'-Methylpiperidine-3'-methyl)thioxanthene
- Aids-001633
- metixene USP/EP/BP
- Methixart
- Piperidine, 1-methyl-3-(9H-thioxanthen-9-ylmethyl)-
- 1-メチル-3-(9H-チオキサンテン-9-イルメチル)ピペリジン
- 9-[(1-メチル-3-ピペリジニル)メチル]-9H-チオキサンテン
- メチキセン
- 1-メチル-3-[(9H-チオキサンテン-9-イル)メチル]ピペリジン
- Parkinson病治療薬