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N-((4-(4-フェニルピペラジン-1-イル)テトラヒドロ-2H-ピラン-4-イル)メチル)-2-(フェニルチオ)ニコチンアミド

N-((4-(4-フェニルピペラジン-1-イル)テトラヒドロ-2H-ピラン-4-イル)メチル)-2-(フェニルチオ)ニコチンアミド 化学構造式
1428327-31-4
CAS番号.
1428327-31-4
化学名:
N-((4-(4-フェニルピペラジン-1-イル)テトラヒドロ-2H-ピラン-4-イル)メチル)-2-(フェニルチオ)ニコチンアミド
别名:
N-((4-(4-フェニルピペラジン-1-イル)テトラヒドロ-2H-ピラン-4-イル)メチル)-2-(フェニルチオ)ニコチンアミド
英語名:
N-((4-(4-phenylpiperazin-1-yl)tetrahydro-2H-pyran-4-yl)methyl)-2-(phenylthio)nicotinamide
英語别名:
JNJ-47965567;JNJ-479655;JNJ-47965567 >=98% (HPLC);JNJ-47965567 (JNJ47965567);N-[[4-(4-PHENYLPIPERAZIN-1-YL)OXAN-4-YL]METHYL]-2-PHENYLSULFANYLPYRIDINE-3-CARBOXAMIDE;N-((4-(4-phenylpiperazin-1-yl)tetrahydro-2H-pyran-4-yl)methyl)-2-(phenylthio)nicotinamide;Inhibitor,P2X7,JNJ-47965567,pain,JNJ 47965567,P2X Receptor,inhibit,neuropathic,JNJ47965567,P2XRs;2-(Phenylthio)-N-[[tetrahydro-4-(4-phenyl-1-piperazinyl)-2H-pyran-4-yl]methyl-3-pyridinecarboxamide;3-Pyridinecarboxamide, 2-(phenylthio)-N-[[tetrahydro-4-(4-phenyl-1-piperazinyl)-2H-pyran-4-yl]methyl]-
CBNumber:
CB83146923
化学式:
C28H32N4O2S
分子量:
488.64
MOL File:
1428327-31-4.mol

N-((4-(4-フェニルピペラジン-1-イル)テトラヒドロ-2H-ピラン-4-イル)メチル)-2-(フェニルチオ)ニコチンアミド 物理性質

貯蔵温度 :
2-8°C
溶解性:
DMF:30.0(Max Conc. mg/mL);61.39(Max Conc. mM)
DMSO:59.62(Max Conc. mg/mL);122.01(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.51(Max Conc. mM)
Ethanol:12.5(Max Conc. mg/mL);25.58(Max Conc. mM)
外見 :
粉
色:
白からベージュ

安全性情報

N-((4-(4-フェニルピペラジン-1-イル)テトラヒドロ-2H-ピラン-4-イル)メチル)-2-(フェニルチオ)ニコチンアミド 価格 もっと(4)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TOC5299
JNJ 47965567 		1428327-31-4 10mg ￥77000 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01TOC5299
JNJ 47965567 		1428327-31-4 50mg ￥328000 2024-03-01 購入
Sigma-Aldrich Japan SML1708 ≥98% (HPLC)
JNJ-47965567 ≥98% (HPLC)		 1428327-31-4 5mg ￥26300 2024-03-01 購入
Sigma-Aldrich Japan SML1708 ≥98% (HPLC)
JNJ-47965567 ≥98% (HPLC)		 1428327-31-4 25mg ￥105000 2024-03-01 購入

N-((4-(4-フェニルピペラジン-1-イル)テトラヒドロ-2H-ピラン-4-イル)メチル)-2-(フェニルチオ)ニコチンアミド 化学特性,用途語,生産方法

説明

JNJ-47965567 is a selective antagonist of the purinergic receptor P2X subtype 7 (P2X7), a ligand-gated ion channel. Activation of P2X receptors by BzATP induces calcium flux, which is reduced by JNJ-47965567 in 1321N1 cells transfected with recombinant P2X7 human, macaque, dog, rat, or mouse protein with pIC50s of 8.3, 8.6, 8.5, 7.2, or 7.5, respectively. JNJ-47965567 suppresses neonatal hypoxia-induced seizures in mice and has some anticonvulsant properties in rats. It also reduces spontaneous seizures in epileptic mice even after treatment is stopped.

使用

2-(Phenylthio)-N-[[tetrahydro-4-(4-phenyl-1-piperazinyl)-2H-pyran-4-yl]methyl]-3-pyridinecarboxamide is a potent and selective human P2X7 antagonist.

Biochem/physiol Actions

JNJ-47965567 is a potent P2X7 antagonist with high affinity for the rat receptor (pKi = 8.7). It is centrally available after systemic injection with a superior brain:plasma distribution compared to other available P2X7 antagonists. JNJ-47965567 was shown to suppress epileptic seizures in a mouse model of epilepsy. It appears to have a disease modifying effect since spontaneous seizure rates did not increase once treatment with JNJ-477965567 was stopped.

N-((4-(4-フェニルピペラジン-1-イル)テトラヒドロ-2H-ピラン-4-イル)メチル)-2-(フェニルチオ)ニコチンアミド 上流と下流の製品情報

原材料

準備製品

N-((4-(4-フェニルピペラジン-1-イル)テトラヒドロ-2H-ピラン-4-イル)メチル)-2-(フェニルチオ)ニコチンアミド 生産企業

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1428327-31-4(N-((4-(4-フェニルピペラジン-1-イル)テトラヒドロ-2H-ピラン-4-イル)メチル)-2-(フェニルチオ)ニコチンアミド)キーワード:

2-(アセチルアミノ)-4-O-β-D-ガラクトピラノシル-2-デオキシ-D-グルコピラノース
  • 1428327-31-4
  • N-((4-(4-phenylpiperazin-1-yl)tetrahydro-2H-pyran-4-yl)methyl)-2-(phenylthio)nicotinamide
  • JNJ-479655
  • N-[[4-(4-PHENYLPIPERAZIN-1-YL)OXAN-4-YL]METHYL]-2-PHENYLSULFANYLPYRIDINE-3-CARBOXAMIDE
  • JNJ-47965567 (JNJ47965567)
  • 2-(Phenylthio)-N-[[tetrahydro-4-(4-phenyl-1-piperazinyl)-2H-pyran-4-yl]methyl-3-pyridinecarboxamide
  • 3-Pyridinecarboxamide, 2-(phenylthio)-N-[[tetrahydro-4-(4-phenyl-1-piperazinyl)-2H-pyran-4-yl]methyl]-
  • JNJ-47965567 >=98% (HPLC)
  • JNJ-47965567
  • Inhibitor,P2X7,JNJ-47965567,pain,JNJ 47965567,P2X Receptor,inhibit,neuropathic,JNJ47965567,P2XRs
  • N-((4-(4-フェニルピペラジン-1-イル)テトラヒドロ-2H-ピラン-4-イル)メチル)-2-(フェニルチオ)ニコチンアミド
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