フィセチン 化学特性,用途語,生産方法
外観
うすい黄色～暗緑褐色、結晶性粉末～粉末
定義
本品は、次の化学式で表される有機化合物である。
解説
フィセチン，黄色の針状晶．分解点348 ℃．λmax 248，319，362 nm．エタノール，酢酸エチル，アセトンに可溶，エーテル，石油エーテル，ベンゼン，クロロホルムに微溶，冷水に不溶．エタノール溶液は種々の金属，希土類の蛍光定量に用いられる．LD50 180 mg/kg(マウス，静注)．
森北出版「化学辞典（第2版）
化粧品の成分用途
皮膚コンディショニング剤、着色剤
製造
フラボノール類の一つ．西インド産のウルシ科Rhus cotinusやサイカチGleditsia japonica Miq.の心材に含まれるフィセチン．
説明
Fisetin, a well-known plant flavonol from natural flavonoid group, is found in traditional medicines, plants, vegetables, fruits. Fisetin also has anti-oxidant, anti-inflammatory, anti-tumor effects
[1].
化学的特性
OCHRE POWDER
使用
Fisetin is used in biological studies as spleen tyrosine kinase inhibitors for autoimmune inflammation disease. This compound has neuroprotective properties.
主な応用
Fisetin is primarily used in laboratory bioactivity studies as an analytical standard for qualitative and quantitative analyses of Fisetin, and as a dietary supplement, and sells well for its potential anti-aging and cognitive enhancing effects. Because of its potent antioxidant and anti-inflammatory properties, it has been shown to have varying degrees of inhibitory effects on a wide range of diseases (e.g., cancer, Alzheimer's disease, anti-aging cells, and diabetes), and has been extensively studied in terms of its pharmacological effects in vitro and in vivo.
利点
Fisetin is known to have antioxidant properties and demonstrates the specific biological activity of protecting functional macromolecules against stress, resulting in a benefit to cellular cytoprotection.It is also known to have anti-inflammatory, chemopreventive, and chemotherapeutic properties.
一般的な説明
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
抗がん研究
Fisetin is a plant polyphenol from the flavonoid group. It occurs in fruits and vegetablesincluding persimmons, strawberries, onions, cucumbers, and apples. It is anantioxidant, exerts anticarcinogenic effects in HCT-116 (human colon carcinoma)cells, and modulates protein kinase and lipid kinase pathways (Wang et al. 2012).Fisetin alter signaling pathway like MAPK, NF-κB, activators of transcription(JAK/STAT), Janus kinase/signal transducers, phosphoinositide-3-kinase-proteinkinase (PI3K/Akt), Wnt, and mammalian target of rapamycin (mTOR), therebyleading to cell cycle arrest in HL-60 cells (human acute promyelocytic leukemiacells) (Singh et al. 2016b). Thus, it exhibits inhibitory effects on adhesion, migration,invasion, and multidrug resistance (Suh et al. 2009).
Source
Fisetin is a plant flavonol from the flavonoid group of polyphenols. It can be found in many plants, where it serves as a yellow/ochre colouring agent. It is also found in many fruits and vegetables, such as strawberries, apples, persimmons, onions and cucumbers.
フィセチン 上流と下流の製品情報
原材料
準備製品