プロメタジン 化学特性,用途語,生産方法
解説
10-(2-dimethylaminopropyl)phenothiazine．C17H20N2S(284.43)．10-フェノチアジンに2-ジメチルアミノプロピルクロリドを反応させてつくる．
"白色の結晶．融点60 ℃，沸点190～192 ℃(0.4 kPa)．長期に空気または湿気にさらすと青色になる．塩酸塩は水に易溶，エタノール，クロロホルムに可溶．分解点223 ℃．強力な抗ヒスタミン薬である．鎮静，催眠作用が強い．諸種のアレルギー症，船酔いや車酔い，皮膚掻痒(そうよう)症，パーキンソン症候群に用いる．LD50 400 mg/kg(ラット，皮下)，5.50 mg/kg(マウス，静脈)．[CAS 60-87-7][CAS 58-33-3:塩酸塩]
森北出版「化学辞典（第2版）
効能
抗アレルギー薬, H1受容体拮抗薬
説明
As a derivative of phenothiazine, promethazine is structurally and pharmacologically similar
to chlorpromazine. It exhibits strong antihistamine activity as well as expressed action
on the CNS. It potentiates action of sedative and analgesic drugs.
使用
Promethazine is used for treating allergic illnesses such as hives, serum disease, hay
fever, dermatosis, and also for rheumatism with expressed allergic components, for allergic
complications caused by antibiotics and other medicinal drugs, and for enhancing
action of analgesics and local anesthetics. Synonyms of this drug are allergen, phenergan,
pipolphen, prothazine, and others.
定義
ChEBI: A tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety.
世界保健機関（WHO）
Introduced in 1946, promethazine, a phenothiazine derivative has
a variety of pharmacological properties. At present it is mainly used as an
antihistamine and anti-motion-sickness drug. Promethazine is listed in the WHO
Model List of Essential Drugs.
一般的な説明
Crystals. Melting point 60°C. Used as an antihistaminic.
空気と水の反応
Turns blue on prolonged exposure to air and moisture.
反応プロフィール
PROMETHAZINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable or toxic gases may be generated in combination with strong reducing agents, such as hydrides.
健康ハザード
SYMPTOMS: Symptoms of PROMETHAZINE include leucopenia; agranulocytosis; confusion; convulsions; stupor; and it potentiates the action of central nervous system depressants.
火災危険
Flash point data for PROMETHAZINE are not available, however PROMETHAZINE is probably combustible.
臨床応用
Promethazine, an early agent in the series, has many useful pharmacological affects other
than being an antihistamine. It has significant antiemetic and anticholinergic properties. It
also has sedative-hypnotic properties and has been used to potentiate the effects of
analgesic drugs. Subsequent analogues, such as trimeprazine and methdilazine, are used as
antipruritic agents in the treatment of urticaria.
安全性プロファイル
Poison by ingestion,
intravenous, intramuscular, intraperitoneal,
and subcutaneous routes. Human systemic
effects by ingestion: pupillary dilation,
wakefulness, hallucinations, and distorted
perceptions. An experimental teratogen.
Other experimental reproductive effectsHuman mutation data reported. A severe
eye irritant. When heated to decomposition
it emits very toxic fumes of NOx and SOx
プロメタジン 上流と下流の製品情報
原材料
準備製品