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Erlotinib D6 HCl

Erlotinib D6 HCl 구조식 이미지

카스 번호:: 1189953-78-3

상품명:: Erlotinib D6 HCl

동의어(영문):: Erlotinib D6;OSI-774 D6 hydrochloride;Erlotiniβ-d6 Hydrochloride;CP-358774 D6 hydrochloride;NSC 718781 D6 hydrochloride;[2H6]-Erlotinib Hydrochloride;Erlotinib Hydrochloride Impurity G

CBNumber:: CB03049808

분자식:: C22H18ClD6N3O4

포뮬러 무게:: 435.933630668

MOL 파일:: 1189953-78-3.mol

속성

안전

용도

공급 업체 37

Erlotinib D6 HCl 속성

저장 조건: Store at -20°C

용해도: DMSO: slightly, heated,Methanol: slightly soluble

물리적 상태: 고체

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H302	삼키면 유해함	급성 독성 물질 - 경구	구분 4	경고		P264, P270, P301+P312, P330, P501

예방조치문구:

P264	취급 후에는 손을 철저히 씻으시오.
P264	취급 후에는 손을 철저히 씻으시오.
P270	이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P301+P312	삼켜서 불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.
P330	입을 씻어내시오.
P501	...에 내용물 / 용기를 폐기 하시오.

NFPA 704

	0
2		0

Erlotinib D6 HCl C화학적 특성, 용도, 생산

개요

Erlotinib-d₆ (hydrochloride) contains six deuterium atoms located on the methoxy group. It is intended for use as an internal standard for the quantification of erlotinib by GC- or LC-MS. Erlotinib is a tyrosine kinase inhibitor that acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity (IC₅₀ = 2.5 μM). This inhibits tumor growth in human head and neck carcinoma (HN5) tumor xenografts in mice with an ED₅₀ value of 9 mg/kg. Erlotinib also suppresses cyclin-dependent kinase 2 (Cdk2) activity in breast cancer cells (IC₅₀ = 4.6 μM) and JAK2 mutant JAK2^V617F (IC₅₀ = 5 μM), which is associated with polycythemia vera, idiopathic myelofibrosis, and essential thrombocythemia. Formulations containing erlotinib are used to treat certain forms of cancer, including non-small cell lung cancer.

용도

Erlotinib D6 HCl is a Selective epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor, Antineoplastic.;Labeled Erlotinib, intended for use as an internal standard for the quantification of Erlotinib by GC- or LC-mass spectrometry.

Erlotinib D6 HCl 준비 용품 및 원자재

원자재

준비 용품

Erlotinib D6 HCl 공급 업체

글로벌( 37)공급 업체

공급자	전화	이메일	국가	제품 수	이점
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14336	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
SIMSON PHARMA LIMITED	+91-8291074273	k.das@simsonpharma.com	India	228	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131980	58
Daicel Chiral Technologies (China)CO.,LTD	021-50460086-9 15921403865	han_yajun@dctc.daicel.com	China	6874	65
ChemStrong Scientific Co.,Ltd	0755-0755-66853366 13670046396	sales@chem-strong.com	China	17993	56
Artis Biotech Co. Ltd.	19138486554 18582380095	sales@artisbio.com	China	2820	58

Erlotinib D6 HCl 관련 검색:

Axitinib OSI-420 4-Methyl Erlotinib Hydrochloride 2,3,5-Trimethylpyridine-1-Oxide Didesmethyl Erlotinib Hydrochloride Salt Erlotinib iMpurity B Icotinib Impurity 1 Erlotinib Erlotinib Impurity 93 Icotinib Impurity 5 2-ETHYNYLANILINE 98 Erlotinib Erlotinib Imp.9 Erlotinib hydrochloride Erlotinib Hydrochloride iMpurity 4-ETHYNYLANILINE DesMethyl Erlotinib Carboxylate Acid 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline