디에틸 아미노말로네이트 하이드로클로라이드
|
|
디에틸 아미노말로네이트 하이드로클로라이드 속성
- 녹는점
- 165-170 °C (dec.)(lit.)
- 저장 조건
- Inert atmosphere,2-8°C
- 용해도
- 클로로포름, DMSO, 물에 용해됨
- 물리적 상태
- 결정성 분말
- 색상
- 흰색에서 약간 노란색
- 수용성
- 녹는
- 감도
- Hygroscopic
- BRN
- 3568037
- InChIKey
- GLFVNTDRBTZJIY-UHFFFAOYSA-N
- CAS 데이터베이스
- 13433-00-6(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
디에틸 아미노말로네이트 하이드로클로라이드 C화학적 특성, 용도, 생산
화학적 성질
white to slightly yellow crystalline powder용도
Diethyl aminomalonate hydrochloride is used as a pharmaceutical intermediate. Diethyl aminomalonate with formaldehyde generates an azomethine ylide which can undergo cycloadditions with 1,2-dipolarophiles to form pyrrolidines.Synthesis
A solution of 420.0 g of a mixture of diethyl hydroxyiminomalonate and diethyl acetoxyiminomalonate (together 2.0 mol) in 400 ml of ethyl acetate, 40.0 g of anhydrous magnesium sulfate and 12.5 g of palladium on activated charcoal (5 percent by weight of Pd) as hydrogenation catalyst were placed in a 1.5 l pressure reactor equipped with a stirrer. At 30° to 35° C., hydrogen was introduced under a pressure of 20 bar for 80 minutes until the pressure remained constant. The reactor contents were thoroughly mixed by stirring during this process. The hydrogenation mixture was cooled to 20° C. and diluted with 200 ml of ethyl acetate and the mixture of hydrous magnesium sulfate and catalyst was filtered off. The solid which had been separated off was washed three times with a total of 200 ml of ethyl acetate and the wash liquor was combined with the filtrate. Diethyl aminomalonate hydrochloride was precipitated out as a white solid by the introduction of 68 g of dry hydrogen chloride, filtered off, washed with ethyl acetate and dried under a water jet vacuum at 70° C. The yield was 359.6 g (85.1% of theory), the melting point was 165° C. and the purity according to the analytically determined chlorine content was 100%.디에틸 아미노말로네이트 하이드로클로라이드 준비 용품 및 원자재
원자재
준비 용품
디에틸 아미노말로네이트 하이드로클로라이드 공급 업체
글로벌( 547)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12456 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9348 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 |
admin@nexconn.com | China | 10248 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 |
info@accelachem.com | United States | 19965 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8823 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
디에틸 아미노말로네이트 하이드로클로라이드 관련 검색:
메틸말론산디에틸에스테르 옥살산디에틸 숙신산 디메틸 프로로말론산디에틸에스테르 브로모말론산디에틸에스테르 에틸말로닐염화물 말론산 디에틸 에틸렌 글리콜 디에틸 에테르 아세트아미도말론 산 디에틸 에스테르 디에틸에테르 디에틸 아미노말로네이트 하이드로클로라이드
Diethyl dibutylmalonate
Mefenpyr-diethyl
Tris(trimethylsilyl)phosphate
2-AMINODIETHYLMALONATE
Topotecan hydrochloride
Diethyl benzylmalonate
CARBAMOYL-DL-ASPARTIC ACID