ChemicalBook >제품 카탈로그 >SU 6656

SU 6656

SU 6656 구조식 이미지

카스 번호:: 330161-87-0

상품명:: SU 6656

동의어(영문):: CS-1672;SU 6656;SU-6656;SU6656 - CAS 330161-87-0 - Calbiochem;N,N-diMethyl-2-oxo-3-((4,5,6,7-tetrahydro-1H-indol-2-yl)Methyl)indoline-5-sulfonaMide;N,N-Dimethyl-2-oxo-3-((4,5,6,7-tetrahydro-1H-indol-2-yl)methylene)indoline-5-sulfonamide;2,3-dihydro-n,n-dimethyl-2-oxo-3-[(4,5,6,7-tetrahydro-1h-indol-2-yl)methylene]-1h-indole-5-sulfonamide;1H-Indole-5-sulfonamide, 2,3-dihydro-N,N-dimethyl-2-oxo-3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-;PTK2 protein tyrosine kinase 2,Focal adhesion kinase,FAK,Akt,SU-6656,PTK2,Inhibitor,Protein kinase B,SU 6656,SU6656,Src,PKB,inhibit

CBNumber:: CB0504775

분자식:: C19H21N3O3S

포뮬러 무게:: 371.45

MOL 파일:: 330161-87-0.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 89

SU 6656 속성

밀도: 1.378±0.06 g/cm3(Predicted)

저장 조건: -20°C

용해도: DMSO: 12mg/mL 주황색 용액

산도 계수 (pKa): 11.87±0.20(Predicted)

물리적 상태: 가루

색상: 오렌지 브라운

InChIKey: LOGJQOUIVKBFGH-YBEGLDIGSA-N

안전

WGK 독일	3

SU 6656 C화학적 특성, 용도, 생산

개요

The Src family of proto-oncogenic kinases include nine mammalian non-receptor tyrosine kinases that are involved in intracellular signaling and are often relevant to carcinogenesis. SU6656 is a selective inhibitor of Src kinases, Including Src, Yes, Lyn, and Fyn (IC₅₀ = 280, 20, 130, 170 nM, respectively). It weakly inhibits some other kinases when used at >10 μM. SU6656 has been used to study the role of Src kinases in cell growth and development in diverse processes, including nervous system development, fibrosis, and cancer.

용도

SU 6656 is a small molecule selective inhibitor of the Src kinase family and induces caspase-independant cancer cell death.

일반 설명

A potent, cell-permeable, reversible, and ATP-competitive inhibitor of Src-family protein tyrosine kinases. Inhibits Src (IC₅₀ = 280 nM) as well as closely related kinases Fyn (IC₅₀ = 170 nM), Yes (IC₅₀ = 20 nM) and Lyn (IC₅₀ = 130 nM). The inhibition is competitive with respect to ATP. Has only a trivial effect on Lck (IC₅₀ = 6.88 μM). Does not affect the activity of PDGF-β receptor kinase (IC₅₀ ≥10 μM) and IGF-1 receptor kinase (IC₅₀ ≥20 μM).

SU 6656 준비 용품 및 원자재

원자재

준비 용품

SU 6656 공급 업체

글로벌( 89)공급 업체

공급자	전화	이메일	국가	제품 수	이점
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32715	60
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	4692	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131980	58

SU 6656 관련 검색:

SU 5416 5-CHLORO-3-[(3,5-DIMETHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE SU 9516 SU 6656