2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-one

2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-one 구조식 이미지
카스 번호:
17952-82-8
상품명:
2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-one
동의어(영문):
1,2,3,4-Tetrahydronorharman-1-one;3,4-Dihydro-β-carboline-1(2H)-one;1,2,3,4-Tetrahydro-β-carboline-1-one;2,3,4,9-tetrahydropyrido[3,4-b]indol-1-one;2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-one;1H-Pyrido[3,4-b]indol-1-one, 2,3,4,9-tetrahydro-
CBNumber:
CB0915201
분자식:
C11H10N2O
포뮬러 무게:
186.21
MOL 파일:
17952-82-8.mol

2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-one 속성

녹는점
183-185 °C
끓는 점
529.2±39.0 °C(Predicted)
밀도
1.318±0.06 g/cm3(Predicted)
용해도
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
물리적 상태
Cryst.
산도 계수 (pKa)
15.48±0.20(Predicted)

안전

2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-one C화학적 특성, 용도, 생산

제조 방법

Tryptamine 380 (9.0 g, 56.2 mmol) and triethylamine (13.8 g, 136.3 mmol) were dissolved in warm toluene (800 mL). Under vigorous stirring, a solution of triphosgene (6.7 g, 22.6 mmol) in toluene (35 mL) was added dropwise and the mixture was stirred for a further 20 min at room temperature. Then, HBr (30% in acetic acid; 13 mL) was added and the mixture was refluxed for 30 min. After cooling to room temperature, water (300 mL) and ethyl acetate (300 mL) were added and, after separation of the layers, the aqueous phase was extracted once more with ethyl acetate (300 mL). The combined organic layers were dried over magnesium sulfate and concentrated in vacuo. The residue was recrystallized from methanol/ethyl acetate (1:1) to afford 7.74 g (74%) of 2,3,4,9-tetrahydro-1H-pyrido[ 3,4-b]indol-1-one 382 as a white solid; mp 184°C.

2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-one 준비 용품 및 원자재

원자재

준비 용품


2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-one 공급 업체

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