GLP-1 (7-37)

GLP-1 (7-37) 구조식 이미지
카스 번호:
106612-94-6
상품명:
GLP-1 (7-37)
동의어(영문):
Tglp-1;GLP-1, 7-37;HuMan GLP-1;Glp-I (7-37);insulinotropin;GLP-1(7-37), >98%;Human GLP-1 (7-37);GLP-1 acetate salt;GLP-1 (7-37) (HUMAN);GLP-1(7-37) impurity
CBNumber:
CB1445727
분자식:
C151H228N40O47
포뮬러 무게:
3355.67
MOL 파일:
106612-94-6.mol

GLP-1 (7-37) 속성

밀도
1.48±0.1 g/cm3(Predicted)
저장 조건
−20°C
용해도
Water:30.0(Max Conc. mg/mL);8.34(Max Conc. mM)
물리적 상태
동결건조된 분말
수용성
2mg/ml로 물에 불용성
시퀀스
H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly-OH
CAS 데이터베이스
106612-94-6

안전

안전지침서 22-24/25
WGK 독일 3

GLP-1 (7-37) C화학적 특성, 용도, 생산

개요

GLP-1 (7-37) is an endogenous truncated form of GLP-1 that arises from proglucagon processing in intestinal endocrine L cells, GLP-1 (7-37) acts as a GLP-1 receptor agonist and is an insulinotropic hormone that augments glucose induced insulin secretion. GLP-1 (7-37) and derivatives GLP-1 (9-37) and GLP-1 (28-37) can reduce plaque inflammation and increase phenotypic characteristics of plaque stability in a murine model of atherosclerosis.

용도

Glucagon-Like Peptide 1 Fragment 7-37 human has been used:
  • as a positive control for insulin secretion of pancreatic islets
  • to test its effect on insulin response in horse islets
  • in combination with mesenchymal stem cells (MSCs) test its protective effects in myocardial infarction

일반 설명

Glucagon-Like Peptide 1 Fragment 7-37 human (GLP-1-(7-37)) is an amino-truncated form of GLP-1.

Biochem/physiol Actions

Glucagon-Like Peptide 1 Fragment 7-37 human (GLP-1-(7-37)) interacts with the GLP-1 receptor (GLP-1r). It mediates insulin release by stimulating the cyclic AMP accumulation in islet cells GLP-l(7-37) is a potential therapeutic agent due to its insulin-secretagogue functionality.

GLP-1 (7-37) 준비 용품 및 원자재

원자재

준비 용품


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