사라고직산A
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사라고직산A 속성
- 알파
- D22 +18.3° (c = 0.60 in CHCl3); D25 +37° (c = 1.29 in methanol)
- 끓는 점
- 850.1±65.0 °C(Predicted)
- 밀도
- 1.35±0.1 g/cm3(Predicted)
- 저장 조건
- −20°C
- 용해도
- DMSO에 용해됨
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 1.47±0.70(Predicted)
- 색상
- 흰색에서 밝은 황갈색
- CAS 데이터베이스
- 142561-96-4
안전
| WGK 독일 | 3 |
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사라고직산A C화학적 특성, 용도, 생산
화학적 성질
White to light tan solid. Soluble in ethanol (10 mg/ml), methanol, DMF, DMSO (10 mg/ml), and water (moderate).용도
Zaragozic acid A is the major metabolite of a class of unusual bicyclic tricarboxylic acids, produced by a number of fungi in the genera Curvularia, Exserohilum, Setosphaeria and others, discovered at Merck and Glaxo in the early 1990s. In nature, zaragozic acid A acts as broad spectrum antifungal but its mode of action as an inhibitor of squalene synthase, involved in sterol biosynthesis, lead to investigation as a cholesterol lowering agent. Zaragozic acid A prepared by BioAustralis is presented as the free acid rather than the tri-sodium salt to avoid stability problems associated with hydrolysis of the salt.정의
ChEBI: Zaragozic acid A is a polyketide isolated from fungi that is a potent inhibitor of fungal and mammalian squalene synthase. It has a role as an EC 2.5.1.21 (squalene synthase) inhibitor and a fungal metabolite. It is a tricarboxylic acid, an acetate ester, a cyclic ketal, an oxabicycloalkane, a tertiary alcohol and a polyketide.주요 응용
Zaragozic Acid A is a squalene synthetase inhibitor. it targeted squalene synthase and lowered the cholesterol levels in vivo of marmosets.사라고직산A 준비 용품 및 원자재
원자재
준비 용품
사라고직산A 공급 업체
글로벌( 31)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226; +16314854226 |
inquiry@bocsci.com | United States | 19743 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 52927 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 |
info@lynnchem.com | China | 4587 | 58 |
| Novachemistry | 44-20819178-90 02081917890 |
info@novachemistry.com | United Kingdom | 4381 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 |
sales@rrkchem.com | China | 55954 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 |
sales@chemegen.com | China | 11289 | 58 |
| Meng Cheng Technology (Shanghai) Co., LTD | 400-820-6829 |
sales@mitachieve.com | China | 8864 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 |
order@med-bio.cn | China | 8141 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 |
marketing@energy-chemical.com | China | 44941 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 18768175414 |
gaojun@univ-bio.com | China | 24998 | 58 |