2'2'-cGAMP
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2'2'-cGAMP 속성
- 끓는 점
- 1159.9±75.0 °C(Predicted)
- 밀도
- 2.61±0.1 g/cm3(Predicted)
- 저장 조건
- Store at -20°C
- 용해도
- 물에 용해
- 물리적 상태
- 결정성 고체
- 산도 계수 (pKa)
- 0.88±0.70(Predicted)
안전
2'2'-cGAMP C화학적 특성, 용도, 생산
개요
2’2’-cGAMP is a synthetic dinucleotide (CDN) that contains non-canonical 2''5''-phosphodiester bonds. It binds to the adapter protein stimulator of interferon genes (STING; Item Nos. 22816 | 22815), which is a component of the innate immune response that activates the type I interferon pathway when bound to cyclic dinucleotides. 2’2-cGAMP shows weaker binding to STING than 2’3’-cGAMP (; Kd = 287 and 3.79 nM, respectively) but binds more strongly than 3’3’-cGAMP , cyclic di-GMP , or 3’2’-cGAMP, which bind in the micromolar range (Kds = 1.04, 1.21, or 1.61 μM, respectively). Despite weaker binding, 2’2’-cGAMP induces IFN-β production in the same concentration range as 2’3’-cGAMP (EC50s = 15.8 and 19.4 nM, respectively, in L929 cells).2'2'-cGAMP 준비 용품 및 원자재
원자재
준비 용품
2'2'-cGAMP 공급 업체
글로벌( 10)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 |
info@bocsci.com | United States | 14059 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 |
info@efebio.com | China | 9709 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 |
sales@glpbio.cn | China | 6870 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 |
sales@chemegen.com | China | 11289 | 58 |
| Nanjing Tengyi Biotechnology Co., Ltd | 025-58851786 17714337195 |
sales@tybiochem.com | China | 5141 | 58 |
| TargetMol Chemicals Inc. | 15002134094 |
marketing@targetmol.com | China | 24246 | 58 |