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TALIPEXOLE

TALIPEXOLE 구조식 이미지

카스 번호:: 101626-70-4

상품명:: TALIPEXOLE

동의어(영문):: Domin;Talipexol;TALIPEXOLE;Talipexolum;Talipexolum [latin];Talipexol [spanish];TALIPEXOLE USP/EP/BP;6-Allyl-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepin-2-amine;6-Allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine;6-Allyl-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[4,5-d]azepin-2-amine

CBNumber:: CB3153213

분자식:: C10H15N3S

포뮬러 무게:: 209.31

MOL 파일:: 101626-70-4.mol

속성

안전

용도

공급 업체 35

TALIPEXOLE 속성

끓는 점: 364.6±37.0 °C(Predicted)

밀도: 1.167±0.06 g/cm3(Predicted)

저장 조건: Store at -20°C

용해도: DMSO에 용해됨

물리적 상태: 가루

산도 계수 (pKa): 7.22±0.20(Predicted)

안전

TALIPEXOLE C화학적 특성, 용도, 생산

개요

Domin was launched in Japan for Parkinson's disease. The compound is readily accessible in two steps from I-allylhexahydro-4H-azepin4-one. Its antiparkinson activity resides in the fact that talipexole is a selective agonist for presynaptic dopamine D₂ receptors with no D₁ receptor activity. It is a clonidine-like α₂-adrenoreptor agonist and has fewer GI side effects than bromocriptine the most widely used dopamine angonist. Also it is 70 times more potent than bromocriptine and has a more rapid onset of action. In addition to its anti-tremor activity there was a sedative effect but no emesis. The latter probably a result of talipexole's 5-HT₃ receptor antagonistic activity. Its metabolites have no biological activity, there was no development of tolerence and its effect could be enhanced by L-dopa.

Originator

Boehringer Ingelheim (Germany)

상표명

Domin

TALIPEXOLE 준비 용품 및 원자재

원자재

준비 용품

TALIPEXOLE 공급 업체

글로벌( 35)공급 업체

공급자	전화	이메일	국가	제품 수	이점
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	9126	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
LGM Pharma	1-(800)-881-8210	inquiries@lgmpharma.com	United States	2127	70
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4863	58
LETOPHARM LIMITED	+86-21-5821 5861	sales@letopharm.com	China	2384	58
Tianjin Kailiqi Biotechnology Co., Ltd.	15076683720	klq@cw-bio.com	China	3501	55
Beijing Solarbio Science & Tecnology Co., Ltd.	010-50973130 4009686088	3193328036@qq.com	China	29796	68
Musechem	+1-800-259-7612	info@musechem.com	United States	4662	60

TALIPEXOLE 관련 검색:

ARANIDIPINE Bendamustine Donepezil CALYXOL ISO-TALIPEXOLE, DIHYDROCHLORIDE TALIPEXOLE DIDHYDROCHLORIDE,Talipexole, 5,6,7,8-Tetrahydro-6-(2-propenyl)-4H-thiazolo[4,5-d]azepine-2-amine dihydrochloride,talipexole hydrochloride 2-(4-METHYL-THIAZOL-5-YL)-ETHYLAMINE TALIPEXOLE 2-(THIAZOL-4-YL)ETHYLAMINE AMTHAMINE DIHYDROBROMIDE 5,6,7,8-TETRAHYDRO-4H-THIAZOLO[4,5-D]AZEPINE 2-(2-AMINOTHIAZOL-4-YL)ETHYLAMINE