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GSK 2801

GSK 2801 구조식 이미지

카스 번호:: 1619994-68-1

상품명:: GSK 2801

동의어(영문):: GSK 280;CS-1607;GSK2801;GSK-2801;GSK 2801;GSK2801, >98%;GSK-2801; GSK 280;GSK2801 GSK-2801;GSK2801;GSK-2801;GSK 2801;1-[1-[2-(Methylsulfonyl)phenyl]-7-propoxy-3-indolizinyl]ethanone

CBNumber:: CB52668513

분자식:: C20H21NO4S

포뮬러 무게:: 371.45

MOL 파일:: 1619994-68-1.mol

속성

안전

용도

공급 업체 83

GSK 2801 속성

밀도: 1.23±0.1 g/cm3(Predicted)

저장 조건: -20°C

용해도: insoluble in H2O; ≥18.55 mg/mL in DMSO; ≥2.82 mg/mL in EtOH with gentle warming and ultrasonic

물리적 상태: 고체

물리적 상태: 단단한 모양

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

위험품 표기	Xn
위험 카페고리 넘버	22

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H302	삼키면 유해함	급성 독성 물질 - 경구	구분 4	경고		P264, P270, P301+P312, P330, P501

예방조치문구:

P280	보호장갑/보호의/보안경/안면보호구를 착용하시오.
P305+P351+P338	눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

GSK 2801 C화학적 특성, 용도, 생산

개요

BAZ2A/B are bromodomain-containing proteins whose biological function is believed to function similarly to ACF1, the Drosophila BAZ2B ortholog. ACF complexes play roles in establishing regular nucleosome spacing during chromatin assembly and influencing different remodeling outcomes at target loci. BAZ2A and BAZ2B constitute the central scaffolding protein of the nucleolar remodeling complex (NoRC) that regulates the expression of noncoding RNAs. GSK2801 is a selective, cell-permeable inhibitor of the BAZ2 family of bromodomain-containing proteins (IC₅₀s = 9-350 nM in a BAZ2B AlphaScreen). It binds to BAZ2A and BAZ2B with K_d values of 0.26 and 0.14 μM, respectively, and does not interact with the bromodomains of BRD4(BD1), CREBBP, TRIM24/TIF1α, PB1(BD5), PCAF, or ATAD2. See the Structural Genomics Consortium (SGC) website for more information.

용도

GSK2801 is a selective cell-permeable inhibitor of the BAZ2 (bromodomain-containing protein) interfering with nucleosome spacing during chromatin assembly.

GSK 2801 준비 용품 및 원자재

원자재

준비 용품

GSK 2801 공급 업체

글로벌( 83)공급 업체

공급자	전화	이메일	국가	제품 수	이점
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32715	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
Jilin Chinese Academy of Sciences-yanshen Technology	+undefined18143011203	info@chemextension.com	China	42057	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	4691	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131980	58

GSK 2801 관련 검색:

GSK2814338 GSK-2256098 GSK-25 S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide 7Methyl-5-(1-{[3-(trifluoroMethyl)phenyl]acetyl}-2,3-dihydro1Hindol-5-yl)7Hpyrrolo[2,3d]pyriMidin-4-aMine GSK2636771 GSK2879552 GSK2795039 GSK 2330672 GSK2838232