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Pomalidomide-PEG4-CO2H

Pomalidomide-PEG4-CO2H 구조식 이미지

카스 번호:: 2138440-81-8

상품명:: Pomalidomide-PEG4-CO2H

동의어(영문):: Pomalidomide-PEG4-COOH;Poma-PEG4-COOH;Pomalidomide-PEG4-CO2H;POMALIDOMIDE-PEG4-CO 2 H;Pomalidomide 4'-PEG4-acid;Thalidomide-NH-PEG4-C2-COOH;1-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]amino]-3,6,9,12-tetraoxapentadecan-15-oic Acid;1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oic acid;Propanoic acid, 3-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-;1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oic acid, Crosslinker–E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader

CBNumber:: CB54846410

분자식:: C24H31N3O10

포뮬러 무게:: 521.52

MOL 파일:: 2138440-81-8.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 23

Pomalidomide-PEG4-CO2H 속성

끓는 점: 773.6±60.0 °C(Predicted)

밀도: 1.385±0.06 g/cm3(Predicted)

저장 조건: 2-8°C

산도 계수 (pKa): 4.28±0.10(Predicted)

안전

Pomalidomide-PEG4-CO2H C화학적 특성, 용도, 생산

용도

Protein degrader builiding block Pomalidomide-PEG₄-CO₂H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology.This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition and E3 ligase ligand.

Pomalidomide-PEG4-CO2H 준비 용품 및 원자재

원자재

준비 용품

Pomalidomide-PEG4-CO2H 공급 업체

글로벌( 23)공급 업체

공급자	전화	이메일	국가	제품 수	이점
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Xian confluore Biological Technology Co., Ltd.	+86-15680926068 +86-15680926068	1924344760@confluore.cn	China	2996	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
ChemShuttle, Inc.	0510-83588313-802 18800520310;	sales@chemshuttle.com	China	2968	62
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9833	58
Aikon International Limited	025-58851090 13611564524	lwan@aikonchem.com	China	15952	58
Xi'an Confluore Biological Technology Co., Ltd.	+86-156-80926068 +86-15680926068	1924344760@qq.com	China	4824	58
Jilin Province Woda Biotechnology Co., Ltd.	13504435624	1927928688@qq.com	China	1360	58
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9414	58

Pomalidomide-PEG4-CO2H 관련 검색:

E3 Ligase Ligand-Linker Conjugates 1 POMALIDOMIDE-PEG2-CO2H Pomalidomide-PEG1-azide Pomalidomide-O-C4-NH2 Propanoic acid, 3-[[17-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3,6,9,12,15-pentaoxaheptadec-1-yl]oxy]- Pomalidomide-PEG3-N3 Pomalidomide-PEG6-butyl iodide Pomalidomide-PEG5-CO2H POMALIDOMIDE-PEG1-CO2H Pomalidomide-PEG3-Amine HCl salt Pomalidomide-PEG3-CO2H 4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione E3 Ligase Ligand-Linker Conjugates 22 Pomalidomide-PEG2-butyl iodide Pomalidomide-PEG4-azide Pomalidomide-PEG2-N3 E3 ligase Ligand-Linker Conjugates 50 POMALIDOMIDE-PEG1-ALKYNE