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Pomalidomide-PEG2-butyl iodide

Pomalidomide-PEG2-butyl iodide 구조식 이미지

카스 번호:: 1835705-72-0

상품명:: Pomalidomide-PEG2-butyl iodide

동의어(영문):: Pomalidomide-2-2-6-I;Pomalidomide-PEG2-butyl iodide;Acetamide, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-2-[2-[(6-iodohexyl)oxy]ethoxy]-;Crosslinker–E3 Ligase ligand conjugate, Pomalidomide-2-2-6-I, N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-2-(2-((6-iodohexyl)oxy)ethoxy)acetamide, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader

CBNumber:: CB74919985

분자식:: C23H28IN3O7

포뮬러 무게:: 585.39

MOL 파일:: 1835705-72-0.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 12

Pomalidomide-PEG2-butyl iodide 속성

끓는 점: 757.7±60.0 °C(Predicted)

밀도: 1.588±0.06 g/cm3(Predicted)

저장 조건: 2-8°C

산도 계수 (pKa): 10.68±0.40(Predicted)

안전

Pomalidomide-PEG2-butyl iodide C화학적 특성, 용도, 생산

용도

Protein degrader builiding block Pomalidomide-PEG₂-butyl Iodide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant iodoalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant iodo group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Pomalidomide-PEG2-butyl iodide 준비 용품 및 원자재

원자재

준비 용품

Pomalidomide-PEG2-butyl iodide 공급 업체

글로벌( 12)공급 업체

공급자	전화	이메일	국가	제품 수	이점
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
Xian confluore Biological Technology Co., Ltd.	+86-15680926068 +86-15680926068	1924344760@confluore.cn	China	2996	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9833	58
Xi'an Confluore Biological Technology Co., Ltd.	+86-156-80926068 +86-15680926068	1924344760@qq.com	China	4824	58
Jilin Province Woda Biotechnology Co., Ltd.	13504435624	1927928688@qq.com	China	1360	58
Shaanxi borno biotechnology co., LTD	+86-13759708231	asherw9@hotmail.com	China	2351	58
Zhengzhou convergence chemical co., LTD	0371-0371-55153829 18003835034	2853979819@qq.com	China	8838	58
Changzhou Bojia Biomedical Technology Co., Ltd.	2122619822	czbjpharma@126.com	China	18488	58

Pomalidomide-PEG2-butyl iodide 관련 검색:

E3 ligase Ligand-Linker Conjugates 50 Pomalidomide-PEG3-CO2H Pomalidomide-PEG4-azide E3 Ligase Ligand-Linker Conjugates 22 4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Pomalidomide-PEG4-CO2H E3 Ligase Ligand-Linker Conjugates 1 POMALIDOMIDE-PEG2-CO2H Pomalidomide-PEG1-azide Pomalidomide-PEG5-CO2H POMALIDOMIDE-PEG1-CO2H Pomalidomide-O-C4-NH2 Propanoic acid, 3-[[17-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3,6,9,12,15-pentaoxaheptadec-1-yl]oxy]- Pomalidomide-PEG3-N3 Pomalidomide-PEG6-butyl iodide Pomalidomide-PEG2-N3