3-아미노-1,2-프로판디올
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3-아미노-1,2-프로판디올 속성
- 녹는점
- 55-57 °C
- 끓는 점
- 264-265 °C739 mm Hg(lit.)
- 밀도
- 1.175 g/mL at 25 °C(lit.)
- 증기압
- <1 hPa (20 °C)
- 굴절률
- n
20/D 1.492(lit.)
- 인화점
- >230 °F
- 저장 조건
- Store below +30°C.
- 용해도
- >1000g/l 가용성
- 물리적 상태
- 액체 (고점도)
- 산도 계수 (pKa)
- 12.11±0.35(Predicted)
- Specific Gravity
- 1.175
- 색상
- 무색~담황색 투명
- 수소이온지수(pH)
- 11 (100g/l, H2O, 20℃)
- 수용성
- 녹는
- 감도
- Hygroscopic
- BRN
- 1719121
- InChIKey
- KQIGMPWTAHJUMN-UHFFFAOYSA-N
- LogP
- -2.079 (est)
- CAS 데이터베이스
- 616-30-8(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | C,Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 34-36/37/38 | ||
| 안전지침서 | 26-36/37/39-45-36 | ||
| 유엔번호(UN No.) | UN 2735 8/PG 2 | ||
| WGK 독일 | 2 | ||
| RTECS 번호 | TY2800000 | ||
| F 고인화성물질 | 10-21 | ||
| 위험 참고 사항 | Corrosive | ||
| TSCA | Yes | ||
| 위험 등급 | 8 | ||
| 포장분류 | III | ||
| HS 번호 | 29221980 | ||
| 독성 | LD50 orally in Rabbit: 7500 mg/kg | ||
| 기존화학 물질 | KE-01565 |
3-아미노-1,2-프로판디올 C화학적 특성, 용도, 생산
개요
3-Amino-1,2-propanediol (APD) is a calcium metabolism regulator useful in the treatment of Paget's disease, tumor-induced hypercalcemia and other bone disorders involving increased osteoclastic activity.화학적 성질
3-Amino-1,2-propanediol is a very viscous transparent colorless to pale yellow liquid with a melting point of 55-57 °C and a boiling point of 264-265 °C. The density at 25 °C is 1.175 g/mL. soluble in water.용도
3-Amino-1,2-propanediol is used in the preparation of iohexol, which is a X-CT non-ionic contrast medium. It acts as a starting material in the production of specialty materials.주요 응용
3-Amino-1,2-propanediol is used as a reactant in the synthesis of lipid-like delivery molecules(lipidoids) for RNA interference (RNAi) therapeutics. It is also used in the synthesis of the bioactive template to prepare cationic α-helical polypeptides and various cationic polymers for gene delivery. It is also used in the synthesis of Decarbazolyl Carvedilol (D212720), a metabolite of Carvedilol (C184625) found in humans, rats, dogs and mice.제조 방법
3-Amino-1,2-propanediol is synthesized by reacting 3-chloro-1,2-propanediol (CPD) with ammonia in alkaline environment by adding sodium hydroxide. Afterwards, the product undergoes a series of purification steps.일반 설명
3-Amino-1,2-propanediol is a chiral glycerol derivative. It could used as a hydrogen bond donor in the design of a new deep eutectic solvent which have emerged as a suitable alternative to VOCs (volatile organic compounds) for diverse practical applications including, among others, drug delivery, electrochemistry, material design, extractions and, of course, organic reactions, alone or together twith other sustainable reaction-media[1]. It can also used as a core present in antiviral compounds to skeleton to design a novel class of anti-adenovirus agents[2].위험도
3-Amino-1,2-propanediol is Danger.H314 (93.33%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
H318 (56.36%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
Safety Profile
Poison by intraperitoneal route.Moderately toxic by ingestion. When heated todecomposition it emits toxic fumes of NOx.저장
3-Amino-1,2-propanediol absorbs moisture and needs to be kept in a container sealed. Store in cool, dry conditions in well-sealed containers.3-아미노-1,2-프로판디올 준비 용품 및 원자재
원자재
준비 용품
3-아미노-1,2-프로판디올 공급 업체
글로벌( 493)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12455 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5993 | 58 |
| Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 |
daisy@crovellbio.com | China | 5964 | 58 |
| Firsky International Trade (Wuhan) Co., Ltd | +8615387054039 |
admin@firsky-cn.com | China | 436 | 58 |
| Sichuan HongRi Pharma-Tech Co.,Ltd | +86-028-64841719 +8615680023009 |
daisy@enlaibio.com | China | 1369 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 16803 | 58 |
| Ouhuang Engineering Materials (Hubei) Co., Ltd | +8617702722807 |
admin@hbouhuang.com | China | 2999 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15932 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21689 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9344 | 55 |