R-(-)-프로필렌 글라이콜

R-(-)-프로필렌 글라이콜
R-(-)-프로필렌 글라이콜 구조식 이미지
카스 번호:
4254-14-2
한글명:
R-(-)-프로필렌 글라이콜
동의어(한글):
R-(-)-프로필렌글라이콜;R-(-)-프로필렌 글라이콜
상품명:
(R)-(-)-1,2-Propanediol
동의어(영문):
(R)-propane-1,2-diol;(R)-1,2-PROPANEDIOL;R-1,2-PD;(R)-1,2-propandiol;(R)-(-)-PROPANEDIOL;(2R)-1,2-Propanediol;(2R)-PROPANE-1,2-DIOL;(R)-(-)-1,2-PROPANEDIOL;(R)-(-)-PROPYLENE GLYCOL;Intermediate For Tenofovir
CBNumber:
CB8249625
분자식:
C3H8O2
포뮬러 무게:
76.09
MOL 파일:
4254-14-2.mol
MSDS 파일:
SDS

R-(-)-프로필렌 글라이콜 속성

녹는점
-57C
알파
-17 º (c=neat)
끓는 점
186-188 °C765 mm Hg(lit.)
밀도
1.04 g/mL at 25 °C(lit.)
굴절률
n20/D 1.434(lit.)
인화점
225 °F
저장 조건
Inert atmosphere,Room Temperature
용해도
Miscible with acetone, chloroform, ethanol (95%), glycerin, and water; soluble at 1 in 6 parts of ether; not miscible with light mineral oil or fixed oils, but will dissolve some essential oils.
산도 계수 (pKa)
14.49±0.20(Predicted)
물리적 상태
투명한 액체
색상
Colorless to Light orange to Yellow
Specific Gravity
1.036
optical activity
[α]20/D 16.5°, neat
감도
Hygroscopic
Merck
14,7855
BRN
1718872
CAS 데이터베이스
4254-14-2(CAS DataBase Reference)
NIST
R-(-)-1,2-propanediol(4254-14-2)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 F,Xn
위험 카페고리 넘버 20-65-15-10
안전지침서 24/25-43-7/8
WGK 독일 1
F 고인화성물질 3
HS 번호 29053200
그림문자(GHS): GHS hazard pictograms
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
예방조치문구:
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
NFPA 704
1
0 1

R-(-)-프로필렌 글라이콜 C화학적 특성, 용도, 생산

화학적 성질

Colorless to light yellow liqui

용도

R-(-)-1,2-Propanediol, is a chiral building blocks that can be used for variety of chemical synthesis.

생산 방법

Propylene is converted to chlorohydrin by chlorine water and hydrolyzed to 1,2-propylene oxide. With further hydrolysis, 1,2- propylene oxide is converted to propylene glycol.

Pharmaceutical Applications

Propylene glycol has become widely used as a solvent, extractant, and preservative in a variety of parenteral and nonparenteral pharmaceutical formulations. It is a better general solvent than glycerin and dissolves a wide variety of materials, such as corticosteroids, phenols, sulfa drugs, barbiturates, vitamins (A and D), most alkaloids, and many local anesthetics.
As an antiseptic it is similar to ethanol, and against molds it is similar to glycerin and only slightly less effective than ethanol. Propylene glycol is commonly used as a plasticizer in aqueous film-coating formulations.
Propylene glycol is also used in cosmetics and in the food industry as a carrier for emulsifiers and as a vehicle for flavors in preference to ethanol, since its lack of volatility provides a more uniform flavor.

저장

At cool temperatures, propylene glycol is stable in a well-closed container, but at high temperatures, in the open, it tends to oxidize, giving rise to products such as propionaldehyde, lactic acid, pyruvic acid, and acetic acid. Propylene glycol is chemically stable when mixed with ethanol (95%), glycerin, or water; aqueous solutions may be sterilized by autoclaving.
Propylene glycol is hygroscopic and should be stored in a wellclosed container, protected from light, in a cool, dry place.

비 호환성

Propylene glycol is incompatible with oxidizing reagents such as potassium permanganate.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (dental preparations; IM and IV injections; inhalations; ophthalmic, oral, otic, percutaneous, rectal, topical, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

R-(-)-프로필렌 글라이콜 준비 용품 및 원자재

원자재

준비 용품


R-(-)-프로필렌 글라이콜 공급 업체

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