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(±)-JQ1

(±)-JQ1 구조식 이미지

카스 번호:: 1268524-69-1

상품명:: (±)-JQ1

동의어(영문):: rac JQ-1;(+/-)-JQ1;(+/-)-SGCBD01;tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate;[(R,S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulen-6-yl]-acetic acid tert-butyl ester;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester;tert-butyl 2-[7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11 ,12-tetraazatricyclo[8.3.0.0,2,6]trideca-2(6),4,7,10,1 2-pentaen-9-yl]acetate

CBNumber:: CB62589817

분자식:: C23H25ClN4O2S

포뮬러 무게:: 456.99

MOL 파일:: 1268524-69-1.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 25

(±)-JQ1 속성

끓는 점: 610.4±65.0 °C(Predicted)

밀도: 1.33±0.1 g/cm3(Predicted)

저장 조건: 2-8°C

용해도: DMSO: 용해성2mg/mL, 투명(가온)

산도 계수 (pKa): 2.05±0.60(Predicted)

물리적 상태: 가루

색상: 흰색에서 베이지색

안정성: 제공된 대로 구매일로부터 1년 동안 안정적입니다. DMSO 또는 에탄올 용액은 -20°에서 최대 2개월 동안 보관할 수 있습니다.

안전

WGK 독일	3

(±)-JQ1 C화학적 특성, 용도, 생산

용도

(±)-JQ1 has been used to study its effect on adipogenesis, by analysing the its impact on the regulation of genes involved in this process especially peroxisome proliferator-activated receptor (PPAR-g), the CCAAT/enhancer-binding protein (C/EBPa) and, STAT5A and B. JQ1 has been used in drug binding assays as a chemical inhibitor of BRD4 to study the CRBN′s substrate recruiting function in mouse and human.

Biochem/physiol Actions

(±)-JQ1 is a Brd4 inhibitor. JQ1 is known to suppress cell proliferation and therefore, can be used as a therapeutic drug for a number of cancers including multiple myeloma and acute myeloid leukemia.

(±)-JQ1 준비 용품 및 원자재

원자재

준비 용품

(R)-(-)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate

(±)-JQ1 공급 업체

글로벌( 25)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Henan Alfa Chemical Co., Ltd	+8618339805032	alfa4@alfachem.cn	China	12755	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
Taizhou Tongxin Bio-Tech Co., Ltd	0523-18601685-898 18652728585	sales@allyrise.com	China	2741	60
Shanghai YuanQi Biotechnology Co., Ltd.	+86-2332782371 +86-18120098618	sales@adobechem.com	China	1250	50
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Taizhou Ruixin Chemical Co., Ltd.	0576-89085261 15867635987	jasonhu09@163.com	China	442	50
Chengdu Saint - Kay Biotechnology Co., Ltd.	028-85157043 15882256948	676046971@qq.com	China	4393	58

(±)-JQ1 관련 검색:

Ko 143 Adapalene (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT Troglitazone