L-페니실아민
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L-페니실아민 속성
- 녹는점
- 206 °C (dec.)(lit.)
- 끓는 점
- 251.8±35.0 °C(Predicted)
- 알파
- 61.9 º (C=0.5 IN 1 M NAOH)
- 밀도
- 1.113 (estimate)
- 굴절률
- 63 ° (C=1, 1mol/L NaOH)
- 저장 조건
- Keep in dark place,Inert atmosphere,Room temperature
- 용해도
- 수성 염기(소량으로 용해), DMSO(약간 용해됨, 가열), 물(약간 용해됨)
- 산도 계수 (pKa)
- 2.13±0.12(Predicted)
- 물리적 상태
- 결정성 분말
- 색상
- 흰색에서 거의 흰색
- optical activity
- [α]24/D +61.9°, c = 0.5 in 1 M NaOH
- Merck
- 14,7088
- BRN
- 1722374
- 안정성
- 흡습성
- InChIKey
- VVNCNSJFMMFHPL-GSVOUGTGSA-N
- CAS 데이터베이스
- 1113-41-3(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi,Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 36/37/38-40-20/21/22 | ||
안전지침서 | 26-36-22-24/25 | ||
WGK 독일 | 2 | ||
RTECS 번호 | YV9445500 | ||
HS 번호 | 29309090 | ||
독성 | LD50 i.p. in rats: 350 mg/kg (Jaffe) |
L-페니실아민 C화학적 특성, 용도, 생산
화학적 성질
white to almost white crystalline powder용도
As a Penicillin metabolite, L-Penicillamine can be used in the treatment of Wilson’s disease, Cystinuria, Scleroderma and arsenic poisoning.Indications
Penicillamine (Cuprimine) can be used to treat acute, severe rheumatoid arthritis, producing reductions in joint pain, edema, and stiffness.The response to penicillamine is usually delayed (4–12 weeks), and remissions can last several months after withdrawal of treatment. Radiographic evidence of this drug’s efficacy is limited; thus, penicillamine is seldom used to treat rheumatoid arthritis.정의
ChEBI: The L-enantiomer of penicillamine.Mechanism of action
The mechanism of action of penicillamine is unknown, but some evidence suggests that it may involve the inhibition of angiogenesis, synovial fibroblast proliferation, or transcriptional activation. Because penicillamine can chelate copper and promote its excretion, it is used to treat Wilson’s disease (hepatolenticular degeneration) and has also been used in mercury and lead intoxication.Pharmacology
Penicillamine is readily absorbed from the GI tract and is rapidly excreted in the urine, largely as the intact molecule. Gradually increasing its dose minimizes side effects, which necessitate discontinuance of penicillamine therapy in perhaps one-third of patients. The most common side effects are maculopapular pruritic dermatitis, GI upset, loss of taste sensation, mild to occasionally severe thrombocytopenia and leukopenia,and mild proteinuria, which at times may progress to the nephritic syndrome. Discontinuance of therapy usually results in a rapid disappearance of side effects.Safety Profile
A poison by intraperitoneal route. Mutation data reported. Whenheated to decomposition it emits toxic vapors of NOx and SOx.Purification Methods
Same as preceding entry for its enantiomer. [Beilstein 4 IV 3228.]L-페니실아민 준비 용품 및 원자재
원자재
준비 용품
L-페니실아민 공급 업체
글로벌( 215)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Jiangxi Chiyan Biopharmaceutical Technology Co.,Ltd. | +86-18616643091 +86-18616643091 |
info@rochipharma.com | China | 246 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 8095 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9348 | 55 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
Zhejiang ZETian Fine Chemicals Co. LTD | 18957127338 |
stella@zetchem.com | China | 2141 | 58 |
Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 |
figo.gao@foxmail.com | China | 7019 | 58 |
Shandong chuangyingchemical Co., Ltd. | 18853181302 |
sale@chuangyingchem.com | CHINA | 5909 | 58 |
Standardpharm Co. Ltd. | 86-714-3992388 |
overseasales1@yongstandards.com | United States | 14336 | 58 |
L-페니실아민 관련 검색:
L-(+)-발린 티오글리콜산 2-에틸헥실 머캡토아세트산 6-머캡토퓨린 3-메르캅토프로피온산 칼슘 티오글리콜산염 티오글리콜산 나트륨 DL-페니실아민 2-머캅토에탄올 페니실아민 멜라티온 L-페니실아민
(1'R,3'S,3S,5R,6R)-5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL
POTASSIUM THIOGLYCOLATE
3-mercapto-L-valine hydrochloride
3-(4-acetylphenyl)-2-aminopropanoic acid hydrochloride
3-METHOXY-L-PHENYLALANINE
(S)-2-AMino-3-(3-iodophenyl)propanoic acid