(2S,3S,4R)-2-CARBOXY-4-ISOPROPYL-3-PYRROLIDINEACETIC ACID
|
|
(2S,3S,4R)-2-CARBOXY-4-ISOPROPYL-3-PYRROLIDINEACETIC ACID 속성
- 녹는점
- 285 °C (decomp)
- 끓는 점
- 416.6±30.0 °C(Predicted)
- 밀도
- 1.187±0.06 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 용해도
- H2O: >10 mg/mL
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 2.11±0.60(Predicted)
- 색상
- 하얀색
- 수용성
- Soluble to 25 mM in water
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
(2S,3S,4R)-2-CARBOXY-4-ISOPROPYL-3-PYRROLIDINEACETIC ACID C화학적 특성, 용도, 생산
개요
Dihydrokainic acid (DHK) is an inhibitor of excitatory amino acid transporter 2 (EAAT2; Ki = 23 μM for glutamate uptake by COS cells expressing EAAT2). It is selective for EEAT2 over EAAT1 and EAAT3 (Ki = >3 mM for both). DHK microinfusion (5 nmol) into the rat infralimbic cortex reduces the time spent immobile in the forced swim test, indicating antidepressant-like behavior, an effect that is blocked by the AMPA receptor antagonist NBQX and the serotonin (5-HT) receptor subtype 5-HT1A antagonist WAY-100635 . It also increases glutamate and serotonin levels and the expression of c-Fos in the dorsal raphe nucleus. In contrast, DHK microinjection (6.25 nmol) into the rat prefrontal cortex (PFC) increases the latency to drink sucrose in a sucrose intake test, indicating anhedonia-like behavior. It also impairs memory acquisition, consolidation, and retrieval in mice in the novel object recognition test.용도
Dihydrokainic acid has been used as a glutamate transporter (GLT-1) inhibitor in the glutamate uptake assay of astrocytes and glial cells. It may be used as a GLT-1 inhibitor in Lateral habenula (LHb).생물학적 활성
EAAT2(GLT1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake (K i = 23 μ M). 130-fold selective over EAAT1 and EAAT3 (K i > 3 mM). Also available as part of the Excitatory Amino Acid Transporter Inhibitor Tocriset™ .(2S,3S,4R)-2-CARBOXY-4-ISOPROPYL-3-PYRROLIDINEACETIC ACID 준비 용품 및 원자재
원자재
준비 용품
(2S,3S,4R)-2-CARBOXY-4-ISOPROPYL-3-PYRROLIDINEACETIC ACID 공급 업체
글로벌( 45)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 32024 | 58 |
Henan Alfa Chemical Co., Ltd | +86-18339805032; +8618339805032 |
alfa4@alfachem.cn | China | 13227 | 58 |
Nextpeptide Inc | +86-0571-81612335 +8613336028439 |
sales@nextpeptide.com | China | 19908 | 58 |
Amadis Chemical Company Limited | 571-89925085 |
sales@amadischem.com | China | 131957 | 58 |
3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 |
3bsc@sina.com | China | 15839 | 69 |
Ascent Scientific | 4401179829988 |
customerservice@ascentscientific.co.uk | United Kingdom | 279 | 60 |
BOC Sciences | 1-631-485-4226; 16314854226 |
info@bocsci.com | United States | 14055 | 65 |
Sigma-Aldrich | 021-61415566 800-8193336 |
orderCN@merckgroup.com | China | 51456 | 80 |
EMMX Biotechnology LLC | 888-539-0666 |
info@emmx.com | United States | 8447 | 60 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 |
info@efebio.com | China | 9806 | 58 |
(2S,3S,4R)-2-CARBOXY-4-ISOPROPYL-3-PYRROLIDINEACETIC ACID 관련 검색:
Ethyl chloroacetate
(2S,3S,4R)-2-CARBOXY-4-ISOPROPYL-3-PYRROLIDINEACETIC ACID
2-(ISOAMYLAMINO)ETHANOL
2-AMINO-3-METHYL-HEXANOIC ACID
3-isopropylglutaric acid
3-(Aminomethyl)-5-methylhexanoic acid
(2S,3S)-3-METHYLPYRROLIDINE-2-CARBOXYLIC ACID
4-METHYL-2-PYRROLIDINE CARBOXYLIC ACID
2-AMINO-3-ETHYL-PENTANOIC ACID
B-N-PROPYLGLUTARIC ACID
(R/S)-2-AMINO-5-METHYLHEXANOIC ACID
3-Pyrrolidineethanol
3-Pyrrolidineacetic acid
(+/-)-THREO-3-METHYLGLUTAMIC ACID