(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5[(R)-hydroxy(phenyl)methyl]tetrahydrofuran-3,4-diol
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(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5[(R)-hydroxy(phenyl)methyl]tetrahydrofuran-3,4-diol 속성
- 끓는 점
- 688.9±55.0 °C(Predicted)
- 밀도
- 1?+-.0.1 g/cm3(Predicted)
- 저장 조건
- Store at -20°C
- 용해도
- DMSO: 60 mg/ml; Ethanol: 60 mg/ml
- 물리적 상태
- 결정성 고체
- 산도 계수 (pKa)
- 12.46±0.70(Predicted)
안전
(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5[(R)-hydroxy(phenyl)methyl]tetrahydrofuran-3,4-diol C화학적 특성, 용도, 생산
개요
LLY-283 is an inhibitor of protein arginine methyltransferase 5 (PRMT5; IC50 = 22 nM). It is selective for PRMT5 over a panel of methyltransferases, including PRMT4, -6, and -7 at 1 μM. It reduces symmetric demethylation of SmBB'' in MCF-7 cells (IC50 = 25 nM) and inhibits proliferation of various breast, gastric, hematological, lung, skin, and ovarian cancer cell lines (IC50s = 3-30 nM). LLY-283 (20 mg/kg) inhibits tumor growth in an A375 mouse xenograft model. It also disrupts alternative splicing events in, and inhibits proliferation and self-renewal of, patient-derived glioblastoma stem cells and increases survival in an orthotopic patient-derived xenograft (PDX) mouse model. See the Structural Genomics Consortium (SGC) website for more information.(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5[(R)-hydroxy(phenyl)methyl]tetrahydrofuran-3,4-diol 준비 용품 및 원자재
원자재
준비 용품
(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5[(R)-hydroxy(phenyl)methyl]tetrahydrofuran-3,4-diol 공급 업체
글로벌( 47)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 |
sales@sarms4muscle.com | China | 10523 | 58 |
NewCan Biotech Limited | +86-0571-86912261 +8613735419629 |
sales@newcanbio.com | China | 9980 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6393 | 58 |
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 |
757984502@qq.com | China | 892 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 57511 | 58 |
Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 |
orders@jknbiochem.com | China | 4691 | 58 |
Amadis Chemical Company Limited | 571-89925085 |
sales@amadischem.com | China | 131980 | 58 |
BOC Sciences | 1-631-485-4226; 16314854226 |
info@bocsci.com | United States | 14059 | 65 |
ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 |
sales-cpd@caerulumpharma.com | China | 3427 | 58 |