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아바카비르-d4

아바카비르-d4 구조식 이미지

카스 번호:: 1260619-56-4

한글명:: 아바카비르-d4

동의어(한글):: 아바카비르-d4

상품명:: Abacavir-d4

동의어(영문):: ABC-d4;Ziagen-d4;1592U89-d4;Abacavir-d4;Abacavir D4 HCl;Abacavir-d₄;(1S,4R)-4-[2-AMino-6-(cyclopropylaMino-d4)-9H-purin-9-yl]-2-cyclopentene-1-Methanol;(1S,4R)-4-[2-Amino-6-[(cyclopropyl-d4)amino]-9H-purin-9-yl]-2-cycpentene-1-methanol;(1S-cis)-4-[2-AMino-6-(cyclopropylaMino-d4)-9H-purin-9-yl]-2-cyclopentene- 1-Methanol;((1S,4R)-4-(2-amino-6-((cyclopropyl-2,2,3,3-d4)amino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol

CBNumber:: CB81565155

분자식:: C14H18N6O

포뮬러 무게:: 286.33232

MOL 파일:: 1260619-56-4.mol

속성

안전

용도

공급 업체 30

아바카비르-d4 속성

녹는점: 222-225°C

저장 조건: -20°C Freezer

용해도: DMSO(약간 용해됨), 메탄올(약간 용해됨)

물리적 상태: 고체

물리적 상태: 단단한 모양

색상: 미색부터 밝은 베이지까지

안정성: 흡습성이 매우 높음

안전

위험 및 안전 성명

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드

예방조치문구:

NFPA 704

	0
2		0

아바카비르-d4 C화학적 특성, 용도, 생산

개요

Abacavir-d₄ is intended for use as an internal standard for the quantification of abacavir by GC- or LC-MS. Abacavir is a nucleoside analog and an inhibitor of HIV-1 reverse transcriptase (K_i = 2.1 μM for the wild-type enzyme). It inhibits replication of a variety of HIV-1 and HIV-2 strains, including strains resistant to 3''-azido-3''-deoxythymidine (zidovudine; ) or 2'',3''-dideoxyinosine (didanosine; ), in HeLa cells stably expressing CD4 (IC₅₀s = 5.8-21 μM). Abacavir inhibits replication of eight HIV-1 clinical isolates in phytohemagglutinin-stimulated isolated human peripheral blood lymphocytes with a mean IC₅₀ value of 0.26 μM. It inhibits hepatitis B virus (HBV) DNA synthesis in HepG2 cells (IC₅₀ = 7 μM) and is also active against human cytomegalovirus (CMV) strain AD169 and the Petaluma strain of feline immunodeficiency virus (FIV) in plaque reduction assays (IC₅₀s = 32 and 0.4 μM, respectively). Formulations containing abacavir have been used in the treatment of HIV infection.

화학적 성질

White Solid

용도

A labelled nucleoside reverse transcriptase inhibitor (NRTI)

아바카비르-d4 준비 용품 및 원자재

원자재

준비 용품

아바카비르-d4 공급 업체

글로벌( 30)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32344	50
Clearsynth Labs Limited	+91-22-26355700	info@clearsynth.com	India	9685	58
Cato Research Chemicals Inc.	020-81960175	min.he@cato-chem.com	China	1958	55
Shenzhen SUNGENING Bio-Medical Co., Ltd.	0755-28967200 13631290199	wxf@sungening.com	China	9507	60
Shenzhen Polymeri Biochemical Technology Co., Ltd.	+86-400-002-6226 13028896684	sales@rrkchem.com	China	55954	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	8740	58
Nanjing Shizhou Biology Technology Co.,Ltd	17301488900	judy.xia@synzest.com	China	12584	58
United States Biological	--	sales@advtechind.com	United States	6106	58

아바카비르-d4 관련 검색:

Abacavir (1S–4R)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol hydrochloride Abacavir Abacavir 5’-Phosphate 2-Cyclopentene-1-methanol, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, (1R-cis)- Abacavir Abacavir Carboxylate (1R,3S)-3-[2-AMino-6-(cyclopropylaMino)-9H-purin-9-yl]cyclopentaneMethanol 2-Amino-6-cyclopropylamino-9H-purine Abacavir 5'-Glucuronide Abacavir (1S,4R)-(4-Aminocyclopent-2-enyl)methanol hydrochloride Abacavir Related CoMpound D trans-Abacavir Hydrochloride Abacavir sulfate 6-aminocarbovir Abacavir Impurity 1 Abacavir Impurity 6